CD36 accelerates the progression of hepatocellular carcinoma by promoting FAs absorption.

CD36 is emerging as a potential strategy for cancer treatment because of its function of regulating fatty acid intake. The purpose of this study was to clarify the molecular mechanism of CD36 in the progression of HCC. TCGA database was used to analyze the relationship of CD36 with HCC.

Zwitterionic Polypeptoids: A Promising Class of Antifouling Bioinspired Materials.

Biofouling caused by protein adsorption and microbial colonization remains a great challenge in many applications. In this work, we synthesized a new type of zwitterionic polypeptoid containing carboxybetaine (CB) moieties (PeptoidCB) through thiol-ene chemistry of poly(N-allylglycine) (PNAG). The zwitterionic antifouling hydrogel was subsequently prepared by co-mixing PeptoidCB with agarose, which exhibited excellent resistance to non-specific protein adsorption and bacterial adhesion.

Hierarchical Approach for Controlled Assembly of Branched Nanostructures from One Polymer Compound by Engineering Crystalline Domains.

The interplay of crystalline packing, which governs atomic length-scale order, and hierarchical assembly, which governs longer length scales, is essential to fabricate complex superstructures from polymers for many applications. Here, we demonstrate that a diblock copolymer containing an -octylglycine peptoid block, which has a propensity to crystallize, can form distinct hierarchical superstructures including a star-like morphology, a superbrush, or a nanosheet by tuning the balance between surface energy arising from the solubility of the copolymers and crystallization energy of the solvophobic polypeptoid blocks. We show that partially ordered micellar aggregates (clusters) are key intermediates that form early in the assembly process and template the formation of superstructures via the oriented fusion of individual micelles as the growth materials.

Polypeptoid-Assisted Formation of Supramolecular Architectures from Folic Acid for Targeted Cancer Therapy with Enhanced Efficacy.

In recent years, much research has focused on assemblies formed by charged polyelectrolytes electrostatic interactions in aqueous solutions as they have the potential to be used in a variety of biomedical applications. In this study, we analyzed supramolecular architectures fabricated from poly(-allyl glycine) modified with cysteamine (PNAG-NH) and folic acid (FA) electrostatic interactions. The PNAG-NH/FA complex exhibits a reversible pH-responsive morphological transformation from vesicles (pH = 7.

The Ser326Cys polymorphism of hOGG1 is associated with intrahepatic cholangiocarcinoma susceptibility in a Chinese population.

Objective: Intrahepatic cholangiocarcinoma is a rare disease whose etiology is far from clear, the Ser326Cys polymorphism in human 8-hydroxyguanine glycosylase (hOGG1) has been shown associated with various cancers, however, the association of Ser326Cys (rsl052133) polymorphism and intrahepatic cholangiocarcinoma susceptibility has not been clarified. The purpose of this study is to investigate whether this polymorphism is related to the genetic susceptibility of intrahepatic cholangiocarcinoma.

Methods: A total 150 patients and 150 normal people were included in this study, the Ser326Cys polymorphisms in each group were genotyped using PCR-RFLP method.

Correlation between B7-H3 expression and matrix metalloproteinases 2 expression in pancreatic cancer.

Background: B7-H3 and matrix metalloproteinases 2 (MMP-2) are reported highly expressed in malignant tumor, we investigate the relationship between B7-H3 expression and MMP-2 on malignant behavior and prognosis predictable value in pancreatic cancer.

Methods: We tested the expressions of B7-H3 and MMP-2 protein in 45 pancreatic surgical resected cancer samples; meanwhile, the clinicopathological data of enrolled patients were obtained for correlation analysis to obtain their relationship with pancreatic cancer progress.

Results: The expression of B7-H3 was up-regulated with infiltrating depth, lymph node metastasis and TNM stage (P < 0.

The preliminary experience in simultaneous treatment of rectal cancer and synchronous liver metastases with laparoscopy.

Background/aims: There is no consensus for laparoscopy first in patients with rectal cancer and synchronous liver metastases, whose metastases are confined to the liver. This study aimed to evaluate its indications for one-stage surgery in laparoscopy.

Materials And Methods: Eighteen patients with rectal cancer and synchronous liver metastases, who had undergone laparoscopic colorectal resection and simultaneous treatment for liver metastases, were retrospectively reviewed.

Laparoscopic spleen-preserving distal pancreatectomy (LSPDP).

Background/aims: To study the feasibility and safety of laparoscopic spleen-preserving distal pancreatectomy (LSPDP).

Methodology: Four patients underwent attempted LSPDP from February 2008 to April 2010 in our department and their clinical data and outcome were reviewed retrospectively.

Results: A total of 4 laparoscopic distal pancreas resections were attempted for 3 female and 1 male patient.

Short-term outcomes from a multicenter retrospective study in China comparing laparoscopic and open surgery for the treatment of infected pancreatic necrosis.

Background: Laparoscopic surgery for confirmed infected pancreatic necrosis (IPN) represents a relatively new solution. There are no studies comparing the outcomes of laparoscopic and open surgery for patients with IPN. The aims of this study were to investigate the feasibility of laparoscopic management for patients with IPN and to compare the outcomes of laparoscopic and open surgery.