Congenital bilateral coloboma of iris and choroid accompanied by unilateral multiple primary pigmented iris cysts: A case report.

Introduction And Importance: Congenital iris and choroidal coloboma is a congenital ocular developmental anomaly, most occur in both eyes, which may exist in isolation or be accompanied by systemic developmental abnormalities. Herein, we report a case of congenital bilateral coloboma of iris and choroid accompanied by unilateral multiple primary pigmented iris cysts. The selection of treatment methods for iris cysts has always been a challenge for ophthalmologists.

The relationship between organizational support, professional quality of life, decent work, and professional well-being among nurses: a cross-sectional study.

Background: Nurses often face challenges such as inadequate welfare protection, injustice, and workplace adversity including violence, bullying, and sexual harassment. In this context, providing sufficient support to nurses is crucial for the promotion of their professional well-being. This study examines the direct and indirect effects of perceived organizational support on nurses' well-being, particularly highlighting the mediating roles of professional quality of life and the perception of decent work.

Loss of an extensive ciliary connectome induces proteostasis and cell fate switching in a severe motile ciliopathy.

Motile cilia have essential cellular functions in development, reproduction, and homeostasis. Genetic causes for motile ciliopathies have been identified, but the consequences on cellular functions beyond impaired motility remain unknown. Variants in and cause severe disease not explained by loss of motility.

Mastigoneme structure reveals insights into the O-linked glycosylation code of native hydroxyproline-rich helices.

Hydroxyproline-rich glycoproteins (HRGPs) are a ubiquitous class of protein in the extracellular matrices and cell walls of plants and algae, yet little is known of their native structures or interactions. Here, we used electron cryomicroscopy (cryo-EM) to determine the structure of the hydroxyproline-rich mastigoneme, an extracellular filament isolated from the cilia of the alga Chlamydomonas reinhardtii. The structure demonstrates that mastigonemes are formed from two HRGPs (a filament of MST1 wrapped around a single copy of MST3) that both have hyperglycosylated poly(hydroxyproline) helices.

Structural specializations of the sperm tail.

Sperm motility is crucial to reproductive success in sexually reproducing organisms. Impaired sperm movement causes male infertility, which is increasing globally. Sperm are powered by a microtubule-based molecular machine-the axoneme-but it is unclear how axonemal microtubules are ornamented to support motility in diverse fertilization environments.

Double Spike-Standard Addition Technique and Its Application in Measuring Isotopes.

Double spike (DS) method has been extensively used in determining stable isotope ratios of many elements. However, challenges remain in obtaining high-precision isotope data for ultra-trace elements owing to the limitations of instrumental signal-to-noise ratios and the systematics of precision of DS-based measurements. Here, the DS-standard addition (SA) (DSSA) technique is proposed to improve measurements of isotope compositions of ultra-trace elements in natural samples.

Novel CD81 Mutations in a Chinese Patient Led to IgA Nephropathy and Impaired BCR Signaling.

Purpose: CD81 deficiency is an extremely rare primary immunodeficiency disease characterized by severe and recurrent infections, IgA-related nephropathy, and profound hypogammaglobulinemia. Only one patient has been reported so far, and the pathogenesis remains unclear. Here, we identified a new case of CD81 deficiency and described its pathogenesis.

Ciliary central apparatus structure reveals mechanisms of microtubule patterning.

A pair of extensively modified microtubules form the central apparatus (CA) of the axoneme of most motile cilia, where they regulate ciliary motility. The external surfaces of both CA microtubules are patterned asymmetrically with large protein complexes that repeat every 16 or 32 nm. The composition of these projections and the mechanisms that establish asymmetry and longitudinal periodicity are unknown.

Investigation on a high gravity device for reduction of NOx emission from marine diesel engines.

High gravity technology, as a process intensification technology, has demonstrated the great advantages in the field of gas purification on account of its excellent mass transfer efficiency and energy-efficient, but it is rarely applied in the field of nitrogen oxides (NOx) purification of marine diesel engine exhaust. In this paper, a high-gravity bowl-shaped-disk rotating bed (HBRB) without catalytic was designed for diesel exhaust after-treatment. A diesel oxidation catalyst (DOC) was installed in the front of the HBRB to regenerate more nitrogen dioxide (NO) easily reduced by urea.

Duck Complement Factor H Binds to Outer Membrane Protein Omp24 of .

The resistance to serum complement-mediated killing is a vital virulence property of microbial pathogens. Complement factor H (FH) is a key negative regulator of the complement alternative pathway (AP) that prevents formation and accelerates the decay of AP C3 convertase and acts as a cofactor in the inactivation of C3b. Pathogens can recruit host FH through their surface proteins to escape the clearance of the complement system.

Chromium isotope fractionation during black shale weathering and its environmental implications.

Black shale contains abundant pyrite and organic matter that are susceptible to weathering when exposed to the air. In the process of weathering, acid mine drainage can be produced, and a range of toxic trace elements including Cr can be released and transported into rivers, groundwater and soils, potentially leading to severe environmental pollution. In order to study Cr migration and Cr isotopic fractionation during black shale weathering, we sampled metalliferous black shales and cherts from two weathering profiles at Shadi and Yutangba from the Permian Maokou Formation in Enshi Prefecture.

Cryo-EM structure of cortical microtubules from human parasite Toxoplasma gondii identifies their microtubule inner proteins.

In living cells, microtubules (MTs) play pleiotropic roles, which require very different mechanical properties. Unlike the dynamic MTs found in the cytoplasm of metazoan cells, the specialized cortical MTs from Toxoplasma gondii, a prevalent human pathogen, are extraordinarily stable and resistant to detergent and cold treatments. Using single-particle cryo-EM, we determine their ex vivo structure and identify three proteins (TrxL1, TrxL2 and SPM1) as bona fide microtubule inner proteins (MIPs).

Factors Affecting the Robustness of Data Inversion for Stable Isotope Measurement Using the Double Spike Method: Insights from Chromium Isotope Analysis.

Stable isotope ratios are widely used to solve environmental, geological, medical, and forensic problems. The double spike technique is considered to be one of the most robust and efficient methods to correct for instrumental mass bias and isotopic fractionation that may occur during sample preparation. However, various hidden errors can arise from data processing and have been largely overlooked in previous studies.

Effect of auricular point pressing therapy on hyperplasia of mammary glands: A protocol for systematic review and meta-analysis.

Background: In recent years, with the accelerated pace of life, diet, environmental problems occur frequently. External factors are easily to cause endocrine disorders and hormone sensitivity of breast tissue, which can lead to mammary hyperplasia. The incidence rate of hyperplasia of mammary glands is increasing year by year, and the age of onset is also getting lower and lower.

Molten Salt Template Synthesis of Hierarchical Porous Nitrogen-Containing Activated Carbon Derived from Chitosan for CO Capture.

Here, hierarchical porous nitrogen-containing activated carbons (N-ACs) were prepared with LiCl-ZnCl molten salt as a template derived from cheap chitosan via simple one-step carbonization. The obtained N-ACs with the highest specific surface area of 2025 m g and a high nitrogen content of 5.1 wt % were obtained using low molten salt/chitosan mass ratio (3/1) and moderate calcination temperature (1000 °C).

High-Sensitivity Measurement of Cr Isotopes by Double Spike MC-ICP-MS at the 10 ng Level.

High-sensitivity and high-precision (2 SD ≤ 0.06‰) measurement of chromium (Cr) isotopes at the 10 ng level was successfully carried out using double spike multiple-collector inductively couple plasma mass spectrometry (MC-ICP-MS). To enhance the signal sensitivity and stability, the Aridus II desolvating nebulizer system was improved by placing its waste gas trap bottle in an ice chamber (5 °C cold trap).

A paleosol record of the evolution of Cr redox cycling and evidence for an increase in atmospheric oxygen during the Neoproterozoic.

Atmospheric oxygen levels control the oxidative side of key biogeochemical cycles and place limits on the development of high-energy metabolisms. Understanding Earth's oxygenation is thus critical to developing a clearer picture of Earth's long-term evolution. However, there is currently vigorous debate about even basic aspects of the timing and pattern of the rise of oxygen.

Improves Defense Against by Regulating ROS and RNS Metabolism, Redox Balance, and Energy Flow in Cucumber Roots.

Plant survival in the terrestrial ecosystem is influenced by both beneficial and harmful microbes. spp. are a group of filamentous fungi that promote plant growth and resistance to harmful microbes.

[Size Distribution and Carbon Component Characteristics of Atmospheric Particulate Matter from Motor Vehicles].

Characterization of the size distribution and carbon components in particulates has become important for identifying the particulates in the atmosphere. The size distribution and carbon components of atmospheric particulate matter from motor vehicles in different regions were analyzed by using Micro-orifice uniform deposition impactors (MOUDI) and the organic carbon/elemental carbon (OC/EC) analyzer. With increasing particle size, the mass concentration of raw diesel/gasoline decreases.