Publications by authors named "Xianglan Fang"
Article Synopsis
- - E3 ligases, specifically TRIM family members, are important in cancer development, but their clinical relevance is not well understood; this study focuses on colorectal cancer (CRC) and identifies 10 TRIM E3 ligases with altered expression levels.
- - TRIM1 is linked to poor prognosis in CRC patients and correlates with higher cancer progression and immune cell infiltration; it promotes cancer cell growth and movement in lab experiments.
- - Mechanistically, TRIM1 facilitates the activation of HIF1α, a key protein for tumor development, by attaching ubiquitin to it, enhancing its nuclear function and interaction with other proteins involved in cell transport.
