Publications by authors named "Xiangkun Chen"
GPNMB Modulates Autophagy to Enhance Functional Recovery After Spinal Cord Injury in Rats.
Cell Transplant
February 2024
Spinal cord injury (SCI) severely affects the quality of life and autonomy of patients, and effective treatments are currently lacking. Autophagy, an essential cellular metabolic process, plays a crucial role in neuroprotection and repair after SCI. Glycoprotein non-metastatic melanoma protein B (GPNMB) has been shown to promote neural regeneration and synapse reconstruction, potentially through the facilitation of autophagy.
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- Temozolomide (TMZ) resistance is a major hurdle in treating gliomas, and this study investigates the role of lysine demethylase 4A (KDM4A) in this context.
- Researchers tested KDM4A levels in glioma cells and examined how targeting KDM4A with siRNA affects cell viability and TMZ effectiveness.
- The study found that KDM4A enhances TMZ resistance by promoting ROCK2 expression and interacting with HUWE1, suggesting that targeting KDM4A could improve glioma treatment outcomes.
FOXM1 maintains fatty acid homoeostasis through the SET7-H3K4me1-FASN axis.
Cell Death Discov
August 2023
Article Synopsis
- Reprogramming of metabolic genes and changes in metabolic traits are common in cancers like glioblastoma (GBM), with FOXM1 playing a key role as a transcription factor that influences various genes.
- SET7 is a protein that modifies other proteins through methylation, impacting gene expression and tumor development by altering histones.
- The study suggests that FOXM1 directly enhances the transcription of SET7, which subsequently activates a pathway (SET7-H3K4me1-FASN) that sustains fatty acid synthesis, a characteristic of cancer cells.