Comparison of resmetirom quantative analysis in API and formulation models based on PXRD, FTIR and Raman scanning imaging combined with univariate and multivariate analyses.

Resmetirom is the first innovative drug for the treatment of non-alcoholic steatohepatitis (NASH), and its two crystal forms, form I and form-2HO, were mentioned in the original patent. The commercially available crystal form of resmetirom was form I. However, the tablets were subject to temperature, pressure, and humidity, and may be converted to form-2HO, which affects the bioavailability and efficacy.

Compressive Behavior of (CuZrAl)Dy Bulk Metallic Glass at Different Strain Rates.

The mechanical properties of (CuZrAl)Dy bulk metallic glass (BMG) were characterized under various strain rates by quasi-static and dynamic compressive tests. In the quasi-static compressive tests, the yield stress of (CuZrAl)Dy BMG increased from 1234 MPa to 1844 MPa when the strain rate was increased from 0.001 s to 0.

Shifts in distribution of herbivorous geese relative to hydrological variation in East Dongting Lake wetland, China.

Studies on distribution dynamics of waterbirds and the relation with hydrological changes are essential components of ecological researches. East Dongting Lake is a Ramsar site and especially important wintering ground for herbivorous geese along the East Asian-Australasian Flyway. In this paper, based on annual (2008/09-2016/17) waterbird census data, we investigated the spatial-temporal distributions of three herbivorous goose species (Lesser White-fronted Goose Anser erythropus, Bean Goose Anser fabalis, and Greater White-fronted Goose Anser albifrons) within East Dongting Lake, and analyzed their distribution dynamics (denoted by percentage similarity index, PSI) relative to variations in hydrological regime.

Impacts of microhabitat changes on wintering waterbird populations.

Caisang Lake, a human-modified wetland, experienced dramatic habitat alterations from the planting of lotus and culturing of crab. Whether the Caisang Lake still maintains populations of wintering waterbirds is of great concern. Here, we compare the changes in waterbird populations before and after habitat alterations in Caisang Lake and assess the driving factors leading to the dramatic changes in waterbird populations.