Hybrid biomineralized nanovesicles to enhance inflamed lung biodistribution and reduce side effect of glucocorticoid for ARDS therapy.

Acute respiratory distress syndrome (ARDS) is a critical illness characterized by severe lung inflammation. Improving the delivery efficiency and achieving the controlled release of anti-inflammatory drugs at the lung inflammatory site are major challenges in ARDS therapy. Taking advantage of the increased pulmonary vascular permeability and a slightly acidic-inflammatory microenvironment, pH-responsive mineralized nanoparticles based on dexamethasone sodium phosphate (DSP) and Ca were constructed.

In situ neutrophil apoptosis and macrophage efferocytosis mediated by Glycyrrhiza protein nanoparticles for acute inflammation therapy.

In the progression of acute inflammation, the activation and recruitment of macrophages and neutrophils are mutually reinforcing, leading to amplified inflammatory response and severe tissue damage. Therefore, to regulate the axis of neutrophils and macrophages is essential to avoid tissue damage induced from acute inflammatory. Apoptotic neutrophils can regulate the anti-inflammatory activity of macrophages through the efferocytosis.

Engineered Biomimetic Nanovesicles Based on Neutrophils for Hierarchical Targeting Therapy of Acute Respiratory Distress Syndrome.

Acute Respiratory Distress Syndrome (ARDS) is a clinically severe respiratory disease that causes severe medical and economic burden. To improve therapeutic efficacy, effectively targeting delivery to the inflamed lungs and inflamed cells remains an ongoing challenge. Herein, we designed engineered biomimetic nanovesicles (DHA@ANeu-DDAB) by fusion of lung-targeting functional lipid, neutrophil membrane containing activated β integrins, and the therapeutic lipid, docosahexaenoic acid (DHA).

Spatial characteristics and coupling coordination between carbon emission efficiency and industrial structure in three metropolitan areas of Jiangsu Province, China.

It is of great practical significance to study the spatial characteristics of carbon emission efficiency, industrial structure, their coupling and coordination relationship for China's green development and industrial structure transformation in the new era. From the perspective of coupling, coordination and space, this paper analyzes and summarizes the spatial characteristics of carbon emission efficiency and industrial structure of 19 cities in three metropolitan areas of Jiangsu Province during 2009-2019 and their coupling and coordination relationship. The carbon emission efficiency in this study is represented by the carbon emission economic efficiency index and carbon emission social efficiency index.