Publications by authors named "Xiangju Chen"
Enhancing Variant Calling in Whole-exome Sequencing Data Using Population-matched Reference Genomes.
Genomics Proteomics Bioinformatics
December 2024
Article Synopsis
- Whole-exome sequencing (WES) is essential for cancer diagnosis, but the current reference genome, GRCh38, is being challenged by new telomere-to-telomere genomes, T2T-CHM13 and T2T-YAO.
- A study of 19 tumor samples from Chinese patients found that T2T-YAO showed about 1% more diversity in exon regions compared to GRCh38, yet it provided 7.41% more mapped reads, indicating better performance.
- The results suggest using population-specific reference genomes like T2T-YAO is crucial for accurate variant analysis, as it reduces false positive variant calls and improves the identification of pathogenic variants in different ethnic groups.
Despite great progress in lithium-sulfur batteries (LSBs), great obstacles still exist to achieve high loading content of sulfur and avoid the loss of active materials due to the dissolution of the intermediate polysulfide products in the electrolyte. Relationships between the intrinsic properties of nanostructured hosts and electrochemical performance of LSBs, especially, the chemical interaction effects on immobilizing polysulfides for LSB cathodes, are discussed in this Review. Moreover, the principle of rational microstructure design for LSB cathode materials with strong chemical interaction adsorbent effects on polysulfides, such as metallic compounds, metal particles, organic polymers, and heteroatom-doped carbon, is mainly described.
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