Publications by authors named "Xianghua Long"
Background: Tuberculosis is prevalent in China, which is the second greatest contributor to the global tuberculosis burden. Tuberculosis meningitis (TBM) is the most severe disease form but few reports describe long-term clinical outcomes and prognostic factors. Thus, we studied these features in Chinese TBM patients.
View Article and Find Full Text PDFStudies have shown that neurofibromin (NF1) restricts GABA release at inhibitory synapses and regulates dendritic spine formation, which may play an important role in temporal lobe epilepsy (TLE). NF1 expression was detected by double-label immunofluorescence, immunohistochemistry, and western blot analysis in the brains of pilocarpine-induced epilepsy model rats at 6 h, 24 h, 72 h, 7 days, 14 days, 30 days, and 60 days after kindling. NF1 was localized primarily in the nucleus and cytoplasm of neurons.
View Article and Find Full Text PDFArticle Synopsis
- The study investigated the role of Npas4 in controlling seizures in rats with pilocarpine-induced epilepsy through various protein detection methods.
- Npas4 levels were found to increase during the acute phase of seizures but decreased in the chronic phase, and it was predominantly located in neuronal nuclei and cytoplasm.
- Knocking down Npas4 led to increased seizure frequency and severity, suggesting that Npas4 plays a protective role against seizures in this model.