YOLOFM: an improved fire and smoke object detection algorithm based on YOLOv5n.

To address the current difficulties in fire detection algorithms, including inadequate feature extraction, excessive computational complexity, limited deployment on devices with limited resources, missed detections, inaccurate detections, and low accuracy, we developed a highly accurate algorithm named YOLOFM. We utilized LabelImg software to manually label a dataset containing 18644 images, named FM-VOC Dataset18644. In addition, we constructed a FocalNext network, which utilized the FocalNextBlock module from the CFnet network.

Weighted gene coexpression network analysis reveals negative regulation of hypertrophic cardiomyopathy by carboxylesterase 1 and cathepsin C.

Hypertrophic cardiomyopathy (HCM) is a primary cardiomyopathy characterized by hypertrophic cardiomyocytes. It is one of the leading causes of sudden death in adolescents. However, the molecular mechanism of HCM is not clear.

KIAA1429 mediates epithelial mesenchymal transition in sorafenib-resistant hepatocellular carcinoma through m6A methylation modification.

Background: Hepatocellular carcinoma (HCC) is a primary liver cancer with high mortality. The long-term use of sorafenib, a targeted drug for hepatocellular carcinoma, will lead to drug resistance, and patients are prone to cancer metastasis, the molecular mechanism of which is still unclear.

Methods: In our study, we constructed a sorafenib-resistant hepatocellular carcinoma cell line (HepG2/Sora) and validated the resistance in vivo and in vitro.

Role of GADD45A in myocardial ischemia/reperfusion through mediation of the JNK/p38 MAPK and STAT3/VEGF pathways.

Rapid recovery of blocked coronary artery blood flow after myocardial infarction (MI) is the key to reducing the size of the infarcted area, improving clinical outcome and decreasing mortality. However, ischemia/reperfusion (I/R) injury has a complicated pathological mechanism and is an inevitable complication of coronary artery blood flow recovery. Growth arrest and DNA damage‑inducible α (GADD45A) serves a vital role in myocardial injury induced by I/R.

New prognostic factors and scoring system for patients with acute myeloid leukemia.

Acute myeloid leukemia (AML) is a malignant disease originating from myeloid hematopoietic stem or progenitor cells. It is important to identify molecules associated with the prognosis of AML and conduct an individual risk assessment for different patients. In the present study, the RNA expression profile of 132 patients with AML and 337 healthy individuals were downloaded from the University of California Santa Cruz Xena and the Genotype-Tissue Expression project databases.

Optimal dimension of edge-lit light guide plate based on light conduction analysis.

Dimensions of the edge-lit light guide plate (LGP) have a non-negligible impact on its output performance based on a pre-determined micro-dot array. However, how the LGP's dimension affects the performance has not been systematically researched. In this paper, the dimension of the LGP is numerically established as a function to the light output performance, which can be divided into four successive procedures.

Numerical Analysis of Droplets from Multinozzle Inkjet Printing.

Multinozzle printing processing with the fabrication of a functional material film lays the foundation for the development of efficient scale production of a photoelectric device. However, a prominent challenge is how to realize the volume uniformity of the droplets. Here, a classical analysis method is introduced first by printing poly(3,4-ethylenedioxythiophene)/poly(styrenesulfonate) (PEDOT:PSS) to analyze the behavior of droplets.

Effect of cigarette smoking on clinical outcomes of hospitalized Chinese male smokers with acute myocardial infarction.

Background: Smoking is known to be a strong risk factor for premature atherosclerosis, acute myocardial infarction (AMI) and sudden cardiac death. According to a cross-sectional survey conducted in 2000 - 2001 in China, the prevalence of smoking among the Chinese men was 60.2%, the highest prevalence in the world.

[The C46359T polymorphism of DNMT3B promoter gene and pathogenesis of acute leukemia].

Objective: To explore the relationship between the polymorphism of C46359T in DNMT3B promoter and the pathogenesis of acute leukemia (AL).

Methods: PCR-RFLP and DNA sequencing were used to analyze the genotypic polymorphism C46359T of promoter in genomic DNA of bone marrow cells/blood lymphocytes from 160 patients with AL and 240 normal controls.

Results: In people of the Hans in China, genotypic frequencies of 2.

[Methylation status of multidrug resistance (mdr1) gene and its correlation with expression of mdr1 gene in patients with hematologic malignancies].

To investigate the correlation between methylation and expression of multidrug resistance (mdr1) gene, restriction endonuclease HpaII combined with competitive PCR technique was used to quantitatively detect the methylation status of two CCGG sites located at -110 and -50 bp (region I and II) up to the transcription start site in mdr1 promoter in 54 AL and 9 MM patients. Semi-quantitative RT-PCR was used to detect the expression level of mdr1 gene. The results showed that inverse correlation between methylation rate of either region or total methylation rate and expression of mdr1 gene was observed.

[The expression of DNA methyltransferase DNMT1, 3A and 3B in acute leukemia and myelodysplastic syndrome].

Objective: To explore the relationship between methyltransferases and the pathogenesis of acute leukemia (AL) and the leukemic transformation of myelodysplastic syndromes (MDS).

Methods: Semi-quantitative RT-PCR method was used to detect the mRNA expression level of DNMT1, 3A and 3B in bone marrow cells from 75 patients with AL or MDS.

Results: There was no significant difference in mRNA expression level of DNMTs between a low-risk MDS group (n = 21) and a normal group.

[The Experimental Study on the TCR Idiotypic DNA Vaccine to Induce Antitumor Immune Response to Lymphocytic Malignancy].

This study was undertaken to investigate the anti-lymphocytic malignacy immunologic effects induced by TCR idiotypic DNA vaccine on BALB/c mice. CEM lymphoma cell line and BALB/c mice were used as models. The rearrangement gene fragment coding TCR Vbeta region of CEM cell line was obtained by RT-PCR technique.

[Experimental study on TCRbeta idiotypic antigenic determinants DNA vaccine to induce anti-lymphoma antibodies].

Objective: To investigate the anti-human CEM lymphoma cell activities induced by TCR idiotypic DNA vaccine containing different antigen determinants in BALB/c mice.

Methods: The specific rearranged gene fragment encoding TCRVbeta region of CEM cell line was obtained by RT-PCR technique. The PCR product was cloned into eukaryocytic expression vector pcDNA3, which was used as DNA vaccine and template for PCR amplifying different antigen determinant.