The relationship between the Hippo signaling pathway and bone metastasis of breast cancer.

Bone is the most common site of metastasis from breast cancer, which is the most prevalent cancer affecting women globally. Bone metastasis from breast cancer severely affects the quality of life of patients and increases mortality. The molecular mechanisms of metastasis, colonization, and proliferation of breast cancer cells in bone are complex and involve the interaction between breast cancer cells and the bone microenvironment.

MicroRNA-3941 targets IGF-1 to regulate cell proliferation and migration of breast cancer cells.

We aimed to investigate the effects and regulatory mechanism of microRNA-3941 (miR-3941) in the progression of breast cancer. The expression of miR-3941 and insulin-like growth factor 1 (IGF-1) was determined in breast cancer tissues and cell lines. A miR-3941 mimics, inhibitor, and scramble RNA were individually transfected into the cancer cells.

[Intervention of rukangyin on the lymphangiogenesis in breast cancer metastasis nude spontaneous mouse model].

Objective: To observe the effects of rukangyin (RKY) on the lymphangiogenesis and lymph node metastasis of breast cancer transplantation tumor mice, thus exploring its anti-tumor metastasis mechanisms.

Methods: Human breast cancer cell line MDA-MB-435S were in situ implanted into the mammary fat pad of 30 female nude mice to establish breast cancer transplantation tumor spontaneous metastasis model. They were randomly divided into six groups, i.