Injectable Double Crosslinked Hydrogel-Polypropylene Composite Mesh for Repairing Full-Thickness Abdominal Wall Defects.

Abdominal wall defects are common clinical diseases, and mesh repair is the standard treatment method. The most commonly used polypropylene (PP) mesh in clinical practice has the advantages of good mechanical properties, stable performance, and effective tissue integration effect. However, direct contact between abdominal viscera and PP mesh can lead to severe abdominal adhesions.

Reversible Single-Crystal-to-Single-Crystal Transformations between Nanoscale 2D Nanosheets and 3D Metal-Organic Frameworks.

Single-crystal-to-single-crystal (SCSC) transformations provide more possibilities for phase transitions, which have attracted great attention in crystal engineering. In this paper, we report a series of reversible SCSC transformations between nanoscale two-dimensional layered double hydroxide (LDH) crystals and three-dimensional metal-organic framework crystals. They can proceed not only in solution systems but also on the surface of solid-state polyacrylonitrile films and fibers.

General synthesis of CoCeMO trimetallic oxides a cation exchange reaction for the oxygen evolution reaction.

Cobalt-based spinel oxides are considered potential candidates for the oxygen evolution reaction (OER) due to their abundant valence changes and promising electrochemical activity, but their low intrinsic activity hinders their practical applications. Herein, we synthesize a series of CoCeMO (M = Zn, Ni, Ru, Er, Mg, Mn, Sn) derived from CoCeM coordination-driven self-assembled aggregates (CDSAAs) using a general ion exchange and subsequent calcination method. Interestingly, CoCeMO exhibit different morphologies from porous nanospheres, particle-stacked nanospheres, to hollow nanospheres as the third metal element is altered.

CoSe nanoparticles anchored on dual 1D carbon nanotubes/N-doped carbon nanofibers as high-performance anodes for sodium-ion storage.

Transition metal chalcogenides (TMCs) have been widely explored and utilized in sodium-ion battery (SIB) anodes owing to their unique advantages, such as high theoretical specific capacity and low cost. However, their inherent defects, such as low electronic conductivity and severe volume expansion, seriously limit the further development of TMC-based anodes. Here, a novel composite material of CoSe nanoparticles (NPs) encapsulated in a dual one-dimensional (1D) carbon composite structure (CoSe@CNTs/N-CNFs) was designed deliberately.

In Situ Simultaneous Cavitation-Doping Approach for Constructing Bimetallic Metal-Organic Framework Hollow Nanospheres with Enhanced Electrocatalytic Hydrogen Production.

This Communication demonstrates a novel and in situ simultaneous cavitation-doping (SCD) approach to construct bimetallic metal-doped cobalt metal-organic framework hollow nanospheres (CoM-MOF HNSs, with M = Ru or Fe). The key point of the SCD approach is the careful balance between the kinetics of Co-MOF being etched and the coordinative growth of a more stable CoM-MOF shell induced by Lewis acid (MCl, with M = Ru or Fe). Our work provides a new method to synthesize bimetallic hollow MOFs and benefits the development of electrocatalysts.

[The status of diabetes prevention awareness among Chinese residents in six provinces].

Objective: To explore the status of diabetes prevention awareness among Chinese residents in order to provide the scientific basis for making intervention strategy.

Methods: A sample of 18-60 years old residents in six provinces was investigated from March to April in 2013.

Results: Totally, 17.

[The study of diabetes-related behavior status and affecting factors among urban and suburban residents in six provinces in China].

Objective: To explore the status of diabetes-related behaviors and affecting factors among urban and suburban residents in China.

Methods: A sample of 18-60 years old residents from Zhejiang, Jiangsu, Shanxi, Henan, Yunnan and Qinghai provinces was investigated by using stratified cluster random sampling method from March to May in 2013, and 4 282 residents were recruited. The Questionnaire of Health Literacy of Diabetes Mellitus of the Public in China was used to conduct the survey.

[A study on health information literacy among urban and suburban residents in six provinces in China].

Objective: To understand the status and its influencing factors of health information literacy among urban and suburban residents in China, and to explore the method for improving the health information literacy.

Methods: From March to May in 2013, residents aged 18-60 years in six provinces in China were investigated with Questionnaire of Health Literacy of Diabetes Mellitus of the Public in China about self-reported health information literacy. The results of the survey were standardized by the 6th national census data.

[An analysis of health literacy about diabetes prevention and control and its influencing factors among the residents in six provinces in China].

Objective: To investigate the health literacy about diabetes prevention and control and its influencing factors among the public in China.

Methods: A multistage stratified random sampling method was applied to investigate urban and rural residents aged 18-60 years among six provinces in China during March and May, 2013. The Questionnaire of Health Literacy of Diabetes Mellitus of the Public in China was used to conduct the survey.

[A study on risk factors and perceptions of diabetes among urban and suburban residents from six provinces in China].

Objective: To study the epidemiological status of diabetes' risk factors among urban and suburban residents and their perceptions of their own health status and risk of diabetes.

Methods: Stratified multi-stage sampling method was used to conduct the survey among 18-60 years old residents from Zhejiang, Jiangsu, Shanxi, Henan, Yunnan, and Qinghai provinces in China from March to May in 2013. The Questionnaire of Health Literacy of Diabetes Mellitus of the Public in China was used to conduct the survey, and then the data were analyzed.

[Status of knowledge and behaviors about chronic diseases prevention for Chinese residents in 2008].

Objective: To learn the status of knowledge and behaviors about chronic diseases prevention for Chinese residents, and to provide basis for developing health education strategy.

Methods: Using multi-stage stratified random cluster sampling, 79 542 residents aged 15-69 years old from 31 provinces (municipalities and autonomous regions) and Xinjiang Production and Construction Corps in Mainland China were investigated with the questionnaire of chronic diseases prevention.

Results: There were 78 429 valid questionnaires recovered.

Deglycosylation or partial removal of HIV-1 CN54 gp140 V1/V2 domain enhances env-specific T cells.

It remains a great challenge to develop an effective HIV vaccine against the most prevalent HIV-1 clade, B'/C recombinant, in China. Our objective was to test the influence of a new modification of the V1/V2 loops of HIV-1(CN54) gp140 on the immunogenicity of Env. HIV-1(CN54) gp140 was deglycosylated by replacing all six N residues in V1/V2 loops with six Q residues (gp140dG) or partially deleted on V1/V2 loops (gp140dV).

Pathogenicity and immunogenicity of recombinant Tiantan Vaccinia Virus with deleted C12L and A53R genes.

Interest is increasing regarding replicating poxvirus as HIV vaccine vector. In China, the Tiantan Vaccinia Virus (TV) has been used most extensively in the battle of eradicating smallpox. Recently, TV was developing as vaccine vector to fight against infectious diseases such as human immunodeficiency virus (HIV).

Immunogenicity comparison between codon optimized HIV-1 CRF BC_07 gp140 and gp145 vaccines.

To develop an effective vaccine against the most prevalent HIV strain "B'/C recombinant" in China, we compared the immunogenicity of B'/C-derived gp140 and gp145. The codon optimized gp140 and gp145 env gene derived from CN54, an ancestor-like B'/C recombinant strain, were synthesized and cloned into a plasmid as DNA vaccines, designated as pDRVISV140 and pDRVISV145, respectively. BALB/c mice were inoculated three times at week 0, 2, and 4 and sacrificed at week 7.

Mucosal priming with replicative Tiantan vaccinia and systemic boosting with DNA vaccine raised strong mucosal and systemic HIV-specific immune responses.

An effective vaccine strategy for HIV-1 will probably require the induction and maintenance of both humoral and cellular immunity at mucosal and systemic sites. We tested a new prime-boost approach of intranasal priming with 3 x 10(6) PFU of replicative recombinant Tiantan vaccinia virus (rTTV) and intramuscular boosting with 100 microg DNA plasmid expressing HIV-1 Gag in BALB/c mice along with other strategies. Our data demonstrated that intranasal priming with replicative recombinant Tiantan vaccinia and intramuscular boosting with DNA vaccine raised the highest vaginal IgA and systemic T-cell responses, and modest lung IgA and sera IgG responses among all vaccination regimens; each vaccination regimen generated its own imprint of the most preferential T-cell receptor usage of Vbeta.

[Intranasal priming with HIV DNA vaccine and systemic boosting with recombinant vaccinia induce vigorous immune responses: experiment with mice].

Objective: To explore the strategy to raise both mucosal and systemic anti-HIV-1 immunity.

Methods: Eighteen BALB/c rats were randomly divided into 2 groups, experimental group and control group. The experimental group were further subdivided into 4 subgroups of 3 mice: 3-dose HIV DNA vaccine group, 3-dose DNA vaccine + cholera toxin (CT) adjuvant subgroup, 1-dose recombinant Tiantan strain vaccinia-based vaccine subgroup, and 3-dose DNA vaccine + CT adjuvant + Tiantan strain vaccinia-based vaccine subgroup.

Mucosal priming with PEI/DNA complex and systemic boosting with recombinant TianTan vaccinia stimulate vigorous mucosal and systemic immune responses.

An effective vaccine strategy for HIV-1 will probably requires the induction and maintenance of both humoral and cellular immunity. We tested a new prime-boost approach of intranasal priming with 10 microg DNA plasmid in the PEI/DNA complexes and boosting with 10(7)PFU of replicative recombinant TianTan vaccinia virus (rTTV) expressing HIV-1 Gag in BALB/c mice. Intranasal priming with PEI/DNA complexes elicited strikingly stronger HIV-specific T-cell (p=0.

HIV-specific T cell immunity across the entire HIV genome in Chinese men who have sex with men.

Background: Man who has sex with man (MSM) is one of the high risk groups for spreading HIV/AIDS. It was reported that the most prevalent human immunodeficiency virus type 1 (HIV-1) strain among MSM is subtype B; however, T cell immunity remains unknown across the HIV-1 B genome in this population.

Methods: Using Elispot assay with synthetic peptides spanning the sequence of HIV-1 consensus B, HIV-1-specific cytotoxic T-cell lymphocyte responses were quantified among 3 treated and 19 untreated HIV-1 infected MSM from Beijing, China.

Sequential priming and boosting with heterologous HIV immunogens predominantly stimulated T cell immunity against conserved epitopes.

Background: The effort to develop an effective preventive vaccine against HIV-1 infection is challenged by the wide genetic diversity of HIV-1 among different isolates.

Objectives: To explore a new vaccination strategy by using heterologous HIV immunogens derived from different clades for sequential priming and boosting.

Methods: HIV Env and Gag immunogens derived from Thailand B (B'), C/B' recombinant and A/E recombinant were selected as these three clades account for 29%, 45% and 15% of HIV-1 prevalence in China, respectively.