Ferrocene Functionalized Upconversion Nanoparticle Nanosystem with Efficient Near-Infrared-Light-Promoted Fenton-Like Reaction for Tumor Growth Suppression.

By taking advantage of the efficient Förster resonance energy transfer (FRET) between near-infrared (NIR)-responsive lanthanide-doped upconversion nanoparticles (UCNPs) and Fenton reagent ferrocenyl compounds (), a series of -UCNPs was designed by functionalizing NaYF:Yb,Tm nanoparticles with - surface-coordination chemistry. -UCNP-Lipo nanosystems were then constructed by encapsulating -UCNP inside liposomes for efficient delivery. -UCNP can effectively release ·OH a NIR-promoted Fenton-like reaction.

Clinicopathological, Immunohistochemical and Molecular Genetic Study on Epithelioid Glioblastoma: A Series of Fifteen Cases with Literature Review.

Purpose: To observe the clinicopathological, immunohistochemical, and molecular genetic features of epithelioid glioblastoma (E-GBM), and identify tumor-associated prognostic factors.

Patients And Methods: The clinical and radiological data of fifteen cases of E-GBM were collected, and their pathological, immunohistochemical, and molecular features were examined. A 1p/19q analysis via FISH, promoter methylation by MS-PCR, and and V600E mutation analysis by HRM-PCR were performed.

SMYD3 controls a Wnt-responsive epigenetic switch for ASCL2 activation and cancer stem cell maintenance.

Tumor growth is fueled by subset of cells with stem cell properties (Cancer stem cells, CSCs). While persistent activation of Wnt/β-catenin signaling confers CSC properties, it remains unclear how epigenetic modifications regulate Wnt target genes to dictate their self-renewal. Here, we report a novel Wnt-responsive epigenetic switch for CSC maintenance through activating the stem cell transcription factor ASCL2 in gastric carcinoma (GC).

A Novel Positive Feedback Loop Between NTSR1 and Wnt/β-Catenin Contributes to Tumor Growth of Glioblastoma.

Background/aims: Neurotensin (NTS), an intestinal hormone, is profoundly implicated in cancer progression through binding its primary receptor NTSR1. The conserved Wnt/β-Catenin pathway regulates cell proliferation and differentiation via activation of the β-catenin/T-cell factor (TCF) complex and subsequent modulation of a set of target genes. In this study, we aimed to uncover the potential connection between NTS/NTSR1 signaling and Wnt/β-Catenin pathway.

Primary esophageal mucosa-associated lymphoid tissue lymphoma: A case report and review of literature.

Rationale: Mucosa-associated lymphoid tissue (MALT) lymphoma is a low grade malignant B cell lymphoma which occurs mainly in the organs having mucosal layer. Though gastrointestinal tract is the most commonly involved extranodal site, primary esophageal MALT lymphoma is very rare with less than 20 cases reported in literature.

Patient Concerns: A 75-year-old man was referred to our hospital for evaluation of dysphagia.

The mechanism of Fe (III)-catalyzed ozonation of phenol.

Fe (III)-catalyzed ozonation yielded better degradation rate and extent of COD (Chemical Oxygen Demand) or oxalic acid as compared with oxidation by ozone alone. Two parameters with strong effects on the efficiency of ozonation are pH of the solution and the catalyst (Fe(3+)) dosage. The existence of a critical pH value determining the catalysis of Fe (III) in acid conditions was observed in phenol and oxalic acid systems.

Treatment of refectory oily wastewater by electro-coagulation process.

Electro-coagulation was used to treat refectory wastewater with high oil and grease contents. Different operational conditions were examined, including pH, current density, reaction time, conductivity, electrode distance and inlet concentration. The optimum current density was 10-14 A m(-2) within 30 min depending on the wastewater properties tested.