Publications by authors named "Xiangfeng Frank Zhao"
Article Synopsis
- - Systemic anaplastic lymphoma kinase-negative (ALK-) anaplastic large cell lymphoma (ALCL) is a diverse disease classified as a unique type by the 2016 WHO, which can involve lymph nodes and other tissues, presenting with significant inflammation.
- - A rare case of systemic ALK- ALCL with unusual myxoid changes is discussed, highlighting specific chromosomal abnormalities that can influence patient outcomes.
- - Accurate diagnosis involves detailed examination of morphology, immunohistochemistry, and molecular analysis, with emphasis on identifying prognostic markers like DUSP22 and TP63 rearrangements for predicting clinical results in ALK- ALCL patients.
Anaplastic lymphoma kinase negative systemic anaplastic large cell lymphoma (ALK-ALCL) is a CD30+ T-cell malignant lymphoma which may involve both lymph nodes and extranodal tissues, showing important clinical differences from ALK-positive ALCL (ALK + ALCL). ALK- ALCL is considered a specific entity by the 2016 World Health Organization (WHO) classification of hematolymphoid neoplasms.We describe an exceptional case of ALK- ALCL with a striking "Hodgkin-like" cytomorphology and a very uncommon nuclear expression of PAX5.
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