Publications by authors named "Xiangbo Jin"
Article Synopsis
- Coronary microvascular disease (CMVD) poses serious heart health risks, yet there's currently no effective noninvasive way to diagnose it, leading to the exploration of the quantitative flow ratio (QMR) as a potential solution.
- This study evaluated QMR's ability to predict CMVD symptoms in patients without obstructive coronary artery disease by comparing it to traditional invasive methods, using data from 66 patients and 103 blood vessels.
- Results indicated that QMR showed strong diagnostic performance with a sensitivity of 82.9% and specificity of 72.6%, suggesting it could be a quicker and more cost-effective alternative for assessing coronary microcirculation.
Background: The correlation between percutaneous coronary intervention (PCI)-related microvascular dysfunction (MVD) and plaque characteristics remains unclear. To investigate this correlation and its prognosis, we assessed changes in MVD by angiographic microvascular resistance (AMR) and intracoronary ultrasound scans after PCI.
Methods: We conducted a retrospective study that enrolled 250 patients with coronary artery disease between July 2016 and December 2018.
Background: Epicardial adipose tissue (EAT) is directly related to coronary artery disease (CAD), but little is known about its role in hemodynamically significant CAD. Therefore, our goal is to explore the impact of EAT volume on hemodynamically significant CAD.
Methods: Patients who underwent coronary computed tomography angiography (CCTA) and received coronary angiography within 30 days were retrospectively included.
Background: Lipoprotein (a) [Lp(a)] is an independent risk factor for coronary artery disease (CAD). Recent studies have indicated that statins tend to increase Lp(a) levels by 10-20%. However, the association of statin-mediated increases in Lp(a) levels with CAD has not been determined.
View Article and Find Full Text PDFBackground: Lipoprotein(a) [Lp(a)] elevation is an important risk factor for coronary artery disease (CAD). However, the correlation between Lp(a) elevations and the risk of recurrent cardiovascular events in patients with established cardiovascular disease is controversial. Some studies have shown that Low-density lipoprotein cholesterol (LDL-C) levels may influence the association between Lp(a) and cardiovascular risk.
View Article and Find Full Text PDF[ gene knockout protects mice from Alzheimer's disease through activating autophagy].
Zhejiang Da Xue Xue Bao Yi Xue Ban
December 2020
Objective: To investigate the protective effect of gene knockout on Alzheimer's disease (AD) in mice.
Methods: The animal model of AD was established by intraperitoneal injection of D-galactose and brain-localized injection of amyloid β-protein (Aβ) in wild type C57BL/6 mice and gene knockout mice. Morris water maze, Y maze and tail suspension test were used to assess the cognitive function and anxiety-like behaviors in mice.