SEC61 translocon subunit gamma enhances low-dose cisplatin-induced cancer-stem cell properties of head and neck squamous cell carcinoma via enhancing Ca-mediated autophagy.

Background/purpose: High () expression is associated with an unfavorable prognosis in patients with head and neck squamous cell carcinoma (HNSCC), but the underlying mechanisms remain poorly understood.

Materials And Methods: HNSCC representative cell lines SCC15 and CAL27 were used to explore the regulation of SEC61G on Ca leak from the endoplasmic reticulum (ER). Caactivated autophagy was monitored by fluorescent labeling of autophagosomes and western blotting assays.

Proliferation-associated 2G4 P48 is stabilized by malignant T-cell amplified sequence 1 and promotes the proliferation of head and neck squamous cell carcinoma.

Background/purpose: Proliferation-associated protein 2G4 () has alternative transcriptional and translational initiation. One dominant transcript could be translated into two protein isoforms (PA2G4-P42 and PA2G4-P48). In this study, we aimed to explore the effects of PA2G4-P42 and PA2G4-P48 on the proliferation of head and neck squamous cell carcinoma (HNSCC) and the mechanisms regulating PA2G4-P48 stability.

[Change of zygomatic and temporal soft tissue after coronal incision].

Objective: To investigate the change of zygomatic and temporal soft tissue after coronal incision.

Methods: A retrospective analysis was performed in 33 patients who received firm fixation for unilateral zygomatic comminuted fracture through semi-coronal incision. All the patients were followed up for more than one year.