Publications by authors named "XiangYun Gai"
Hypoxic pulmonary hypertension (HPH), a chronic condition affecting the cardiopulmonary system, has high mortality. Echinacoside (ECH) is a phenylethanoid glycoside, which is used to ameliorate pulmonary vascular remodeling and pulmonary vasoconstriction in rats. Accordingly, we aimed to explore the mechanism of ECH in preventing and treating HPH.
View Article and Find Full Text PDFArticle Synopsis
- - Research suggests that hypoxic pulmonary hypertension (HPH) activates the sympathetic nervous system, increasing norepinephrine (NE) release, which can lead to calcium overload and abnormal cell growth in pulmonary artery smooth muscle cells (PASMCs), contributing to vascular remodeling.
- - The study examines how echinacoside (ECH) treatment affects these mechanisms, using NE-induced PASMCs to mimic the calcium overload and abnormal proliferation seen in HPH.
- - Results show that ECH effectively reduces calcium levels and PASMC proliferation in a concentration-dependent manner, lowers the expression of certain proteins linked to this process, and significantly improves symptoms in HPH rat models by decreasing mean pulmonary artery pressure and alleviating pulmonary vascular remodeling.
is an ancient mineral-herbal mixture containing β-HgS in Tibetan medicine. It is used to treat nervous system diseases, similar to Chinese medicine cinnabar and Indian Ayurveda medicine . However, one of the key problems faced by is that its indications are ambiguous.
View Article and Find Full Text PDFPurpose: University freshmen are particularly vulnerable as they are undergoing the transition from high school to university with a range of changes. Sleep problems among this group in the Qinghai-Tibet Plateau of China were barely studied. This study aimed to explore sleep disturbance, and its association with quality of life (QoL) and demographic and clinical characteristics among university freshmen in Qinghai-Tibet Plateau, China.
View Article and Find Full Text PDFHarv. is a well-known succulent plant that have important ornamental and economic value. In this study, we release and detail the complete chloroplast genome sequences of .
View Article and Find Full Text PDFArticle Synopsis
- University students often experience insufficient sleep, which can lead to various negative outcomes, and there may be significant differences in sleep duration and its correlates between male and female students.
- A study conducted in Qinghai Province, China with over 5,500 participants found that female students had a shorter average sleep duration (6.84 hours) compared to male students (6.94 hours), and a notable percentage (35%) were not getting enough sleep.
- Factors affecting sleep duration vary by sex, with females influenced by age, academic pressure, and depressive symptoms, while males were more affected by smoking habits and internet use; breakfast frequency positively correlated with longer sleep for both sexes.
Turcz. ex Ledeb. is a well-known herbaceous perennid that has been used as a traditional medicine to treat influenza, hepatitis, and detoxfeaction.
View Article and Find Full Text PDFHypoxic pulmonary hypertension (HPH) is a progressive and irreversible disease that reduces survival. Echinacoside is a phenylethanoid glycoside from Tibetan herbs known for its vasorelaxant effect and for inhibiting the proliferation of rat pulmonary arterial smooth muscle cells. This study aimed to investigate the effect of echinacoside on HPH.
View Article and Find Full Text PDFAim: Sustained pulmonary vasoconstriction as experienced at high altitude can lead to pulmonary hypertension (PH). The main purpose of this study is to investigate the vasorelaxant effect of echinacoside (ECH), a phenylethanoid glycoside from the Tibetan herb Lagotis brevituba Maxim and Cistanche tubulosa, on the pulmonary artery and its potential mechanism.
Methods: Pulmonary arterial rings obtained from male Wistar rats were suspended in organ chambers filled with Krebs-Henseleit solution, and isometric tension was measured using a force transducer.
The main purpose of this study is to evaluate the effect of echinacoside (ECH) on hypoxia-induced proliferation of rat pulmonary artery smooth muscle cells (PASMCs) and the underlying mechanism. PASMCs were incubated under normoxia (nor), hypoxia (hyp), hypoxia + 0.35 mM ECH (hyp + ECH0.
View Article and Find Full Text PDF