Marine natural product-inspired discovery of novel BRD4 inhibitors with anti-inflammatory activity.

Bromodomain-containing protein 4 (BRD4) has been identified as a promising target in drug discovery, and the development of novel specific BRD4 bromodomain inhibitors will benefit anti-inflammatory drug discovery as well as bromodomain function role disclose. Herein, inspired by marine quinazolinone alkaloid penipanoid C, we designed and synthesized a series of quinazolin-4(3H)-ones with diverse linkers between two aromatic ring systems. Among them, compound 25 possessed good in vitro BRD4 inhibitory activities (IC = 3.

Toward Green Liquid Nitrogen Fertilizer Synthesis: Plasma-Driven Nitrogen Oxidation and Partial Electrocatalytic Reduction.

Liquid fertilizers, particularly when integrated with precision irrigation systems, offer a more efficient and sustainable alternative to traditional solid nitrogen fertilizers. The industrial production of ammonium nitrate (NHNO) is environmentally detrimental due to its reliance on fossil fuels. This study introduces an innovative air-to-NOx-to-NHNO pathway for synthesizing liquid nitrogen fertilizer.

A multicentre, prospective cohort study comparing two endoscopic procedures for the treatment of gastric muscularis propria lesions.

To date, no prospective study has been conducted to compare the safety and effectiveness of endoscopic snare resection with an elastic band (ESR-EB) and endoscopic snare resection with a transparent cap (ESR-C) for treating gastric muscularis propria lesions. We aimed to compare the safety and effectiveness of ESR-EB with those of ESR-C for gastric muscularis propria lesions less than 10 mm in diameter. A total of 64 patients were enrolled prospectively from May 2023 to November 2023 at Shenzhen Hospital of Southern Medical University, the First Affiliated Hospital of Shantou University, and the People's Hospital of Zhongshan City.

Genome-wide identification, phylogeny, evolutionary expansion, and expression analyses of ABC gene family in Castanea mollissima under temperature stress.

The ATP-binding cassette (ABC) gene family comprises some of the most critical transporter proteins in plants, playing vital roles in maintaining cellular homeostasis and adapting to environmental changes. While ABC transporters have been extensively characterized in various plant species, their profile in C. mollissima remains less understood.

Impairment of white matter microstructure and structural network in patients with systemic lupus erythematosus.

Objective: The study aimed to investigate the damage of white matter (WM) microstructure and structural network in patients with systemic lupus erythematosus (SLE) using diffusion tensor imaging.

Methods: Tract-based spatial statistics (TBSS) were used to compare the difference in WM fractional anisotropy (FA) between SLE and HCs groups. The differences in WM networks between groups are compared using graph theory.

The application of new type ureteroscope and traditional linear ureteroscope in ureteric stone patients.

Objective: A ureteric stone is a type of urinary tract stone that is found within the ureter. While most cases can be managed with conservative treatment or minimally invasive surgery, these methods often cause significant pain for the patient. Interestingly, a new type of ureteroscope has shown considerable promise in treating patients with ureteric stones, and this study aims to explore its clinical application.

Scalable fabrication of biohybrid magnetic MOF-based micromotors for toxin enrichment.

Contemporary industrial production and human activity release numerous toxins into our environment. Metal-organic frameworks (MOFs) are potential candidates for addressing these toxins due to their ultrahigh surface area, tailored pore size, and responsiveness to stimuli. With the rise of micro/nanomotor, imparting active motion to MOFs becomes crucial for efficiently performing tasks in challenging locations.

Differential Expression Spectrum of circRNA in Plasma Exosomes in Dilated Cardiomyopathy With Heart Failure.

Dilated cardiomyopathy (DCM), a form of non-ischaemic myocardial disease, is characterised by structural and functional cardiac abnormalities. As defined by the World Health Organisation, DCM constitutes a significant cardiac pathology, leading to increased morbidity and mortality due to complications such as heart failure and arrhythmias. The diagnostic process for DCM predominantly employs echocardiography and MRI, with biomarkers like NT-pro BNP and troponin providing supportive, yet non-specific, evidence.

Comparison and analysis of deep learning models for discriminating longitudinal and oblique vaginal septa based on ultrasound imaging.

Background: The longitudinal vaginal septum and oblique vaginal septum are female müllerian duct anomalies that are relatively less diagnosed but severely fertility-threatening in clinical practice. Ultrasound imaging is commonly used to examine the two vaginal malformations, but in fact it's difficult to make an accurate differential diagnosis. This study is intended to assess the performance of multiple deep learning models based on ultrasonographic images for distinguishing longitudinal vaginal septum and oblique vaginal septum.

Adipose Stem Cells Prevent Esophageal Strictures After Extensive Endoscopic Submucosal Dissection-Experimental Research.

Background And Aims: Endoscopic submucosal dissection (ESD) is a pivotal technique for excision of early-stage esophageal tumors. However, its primary complication, postoperative esophageal stricture, is a significant challenge owing to the absence of effective preventive measures. Adipose-derived stem cells (ADSCs) have emerged as a promising treatment modality to address this concern.

Targeting piRNA-137463 Inhibits Tumor Progression and Boosts Sensitivity to Immune Checkpoint Blockade via De Novo Cholesterol Biosynthesis in Lung Adenocarcinoma.

The important role of PIWI-interacting RNAs (piRNAs) in tumors has garnered increasing attention. However, research on their role in lung adenocarcinoma (LUAD) remains limited. Elevated levels of piRNA-137463 have been linked to poor prognosis in LUAD patients.

The close association of Muribaculum and PA (10:0/a-17:0) with the occurrence of pancreatic ductal adenocarcinoma and immunotherapy.

Background: Progress in immunotherapy for pancreatic ductal adenocarcinoma (PDAC) has been slow, yet the relationship between microorganisms and metabolites is crucial to PDAC development. This study compares the biliary microbiota and metabolomic profiles of PDAC patients with those of benign pancreatic disease patients to investigate PDAC pathogenesis and its relationship with immunotherapy.

Methods: A total of 27 patients were recruited, including 15 diagnosed with PDAC and 12 with benign pancreaticobiliary conditions, all of whom underwent surgical treatment.

Exploration of mechanical properties and osseointegration capacity of porous PEEK composites containing strontium and alendronate under 3D printing: an emerging bone implant.

The aim of this study was to evaluate the biomechanical and osseointegrative properties of 3D printed porous PEEK materials loaded with strontium (Sr) and alendronate (ALN), which prepared porous cylindrical material by a fused deposition molding process, coated with Sr and ALN by hydrothermal reaction and dopamine assistance. According to the different coating materials, it could be divided into the PEEK group, PEEK-ALN group, PEEK-Sr group and PEEK-ALN-Sr group. After completing the mechanical analyses, the materials were implanted into the femoral condyles of New Zealand rabbits and the osteogenic capacity of the bracket materials was assessed by Micro-CT scanning, histology and fluorescence staining.

Integrative analysis of recurrence related gene signature and STC1 in colorectal cancer proliferation and metastasis.

Colorectal cancer remains a formidable global health challenge, characterized by high recurrence rates and poor prognosis. This study introduces a novel Recurrence Related Gene Signature (RRGS), designed to predict therapy response and enhance prognostic accuracy in colorectal cancer. Through analysis of the GSE17536 cohort, we identified 79 differentially expressed genes (DEGs) between recurrent and non-recurrent cases, comprising 54 upregulated and 25 downregulated genes.

Conversion of human glial cells into neurons in ex vivo culture of human brain tissue: essential roles of the transcription factors NeuroD1 and Ascl1.

Transcription factor-mediated cell conversion has been reported in the central nervous system of both rodents and nonhuman primates. In particular, glia-to-neuron conversion has been achieved in the brain and spinal cord of animal models for neural regeneration and repair. However, whether glia-to-neuron conversion can be used for brain repair in humans needs to be explored.

Investigation on the Changes of Perioperative Psychological State of Young Patients With Early Breast Cancer.

Objective: This study aims to explore the variations and dynamics in the mental states of young patients with early breast cancer across different perioperative periods and to analyse how different surgical methods impact these patients' psychological well-being.

Methods: A prospective observational study was conducted on young patients with early breast cancer who underwent surgery from March 2021 to March 2022. Mental status questionnaires were administered at four key time points: preoperatively, 1 month, 6 months and 1 year postoperatively.

Identification of Key Risk Factors for Rupture in Small Intracranial Aneurysms: A Multicenter Study.

Background And Purpose: Predicting rupture risk in small intracranial aneurysms (IAs) < 5 mm is crucial for guiding clinical decisions. This study aims to identify key clinical and morphological risk factors associated with rupture in small IAs, providing better insight for decision-making.

Methods: A retrospective analysis was performed on patients with small IAs from one center, with external validation data from another center.

Arbuscular mycorrhizal type increases the negative feedback of soil microbial biomass to nitrogen deposition.

Soil microbes are crucial for ecosystem health and functioning, playing key roles in decomposing organic matter, nutrient cycling, and carbon sequestration. Mycorrhizal fungi, a vital group of soil microbes, establish symbiotic relationships with plant roots, enhancing plant nutrient uptake and improving soil structure. Globally nitrogen (N) enrichment is recognized as a significant regulator of soil microbial communities.

The analysis of credit governance in the digital economy development under artificial neural networks.

This paper aims to provide new avenues for innovation in credit governance in the digital economy to provide more reliable credit evaluation solutions for financial, commercial, and social interactions. This paper integrates the potential value of Internet of Things (IoT) technology in credit governance and proposes a credit governance method that utilizes IoT data and an improved Long Short-Term Memory model. The proposed model introduces an adaptive mechanism to monitor changes in data in real-time and automatically adjust network parameters to improve the model performance.

Single-cell transcriptomic analysis of glioblastoma reveals pericytes contributing to the blood-brain-tumor barrier and tumor progression.

The blood-brain barrier is often altered in glioblastoma (GBM) creating a blood-brain-tumor barrier (BBTB) composed of pericytes. The BBTB affects chemotherapy efficacy. However, the expression signatures of BBTB-associated pericytes remain unclear.

Probiotic DNA regulates intestinal Th2 polarization by inducing epithelial cells to produce PD-L1.

Th2 polarization is a characteristic feature of many immune diseases; its pathogenesis is still being elucidated. Probiotics have immune regulatory effects. This study is aimed at testing the impact of Lactobacillus rhamnosus (LR) DNA on regulating Th2 polarization and elucidating its underlying mechanism.

[Soil Fertility and Influencing Factors of Cultivated Land Based on the Geodetector].

Taihe County in Jiangxi Province was chosen as the study area to analyze the soil fertility condition and affecting elements of cultivation at the county level. Classical statistics, geostatistics, and geodetector were utilized to examine soil fertility quality and investigate its primary affecting aspects based on experimental data from 206 cultivated soil samples. The results showed that： ① Taihe County had an average soil pH of 4.