Hippocampus carbonic anhydrase 1 via ERK pathway may be involved in depressive like behaviors.

Major depressive disorder (MDD) is a destructive mental disease, yet the mechanism is still not clear. Carbonic anhydrase, an efficient catalyst for CO conversion to carbonate and protons, could affect many functions, such as memory formation recognition. Lately, we illustrated that carbonic anhydrase 1 (CAR1) knockout (CAR1) mice could lead to depressive-like behaviors, but the underlying molecular mechanism is unknown.

A wearable triboelectric impedance tomography system for noninvasive and dynamic imaging of biological tissues.

Tissue imaging is usually captured by hospital-based nuclear magnetic resonance. Here, we present a wearable triboelectric impedance tomography (TIT) system for noninvasive imaging of various biological tissues. The imaging mechanism relies on the obtained impedance information from the different soft human tissues.

Prolactin Inhibition Promotes Follicle Recruitment by Increasing Expression in Ewes During the Estrus Stage.

Prolactin (PRL) plays a key role in the growth and ovulation of animal follicles, but its impact on follicular recruitment in ewes remains uncertain. In this study, a total of sixteen healthy ewes (Hu sheep, aged 2-3 years, with continuous reproduction and housed separately), matched for parity and weight (52.98 ± 0.

Eco-friendly antibacterial electrospinning nanofibrous film containing nano-silver green-synthesized by natural glycoprotein for infected wound healing.

Infected wounds caused by bacteria commonly cause delayed wound healing and even serious tissue damage, evolving into one of the most problematic clinical issues. Traditional therapies and wound dressings cannot achieve either the ideal antibiotic activity or the accelerated wound healing outcomes. Based on our previous finding that glycoproteins (PAGP) derived from medicinal animal insect Periplaneta americana L.

Adhesive thermosensitive polydopamine hydrogel containing MnO anchored halloysite clay for treatment of ulcerative colitis.

Ulcerative colitis (UC), a common inflammatory bowel disease, causes ulcers of the colon and rectum. One of the important reasons for intestinal lesions caused by UC is that immune cells produce large amounts of reactive oxygen species (ROS). Herein, we developed an adhesive thermosensitive polydopamine hydrogel containing MnO nanozyme anchored halloysite nanotubes (MnO@HNTs@PDA) to remove ROS produced by immune cells and treatment of UC.

Sugary beverages intake and risk of chronic kidney disease: the mediating role of metabolic syndrome.

Background: Although several studies linked the sugary beverages to chronic kidney disease (CKD), the role of different types of sugary beverages in the development of CKD remained inconsistent. This study aimed to examine the associations of sugar-sweetened beverages (SSBs), artificially-sweetened beverages (ASBs), and natural juices (NJs) with CKD risk, and assess the extent to which the associations were mediated through metabolic syndrome (MetS).

Methods: This is a prospective analysis of 191,956 participants from the UK Biobank.

N-heterocyclic nitrenium-catalyzed photosynthesis of 3,3-disubstituted oxindoles from α-chloroanilides.

The radical cascade reaction of α-halogenated anilides represents an efficient approach for synthesizing 3,3-oxindoles. However, most methods have focused on α-bromoanilides, with limited utilization of the more stable and readily available α-chloroanilides. In addition, the transition-metal-free preparation of 3,3-oxindoles has been far less explored.

Triboelectric sensor with ultra-wide linear range based on water-containing elastomer and ion-rich interface.

The incompatibility of the high sensitivity and wide linear range still restricts the further development of active sensors. Here we report a triboelectric pressure sensor based on water-containing triboelectric elastomer with gradient-based microchannels. Tiny amount of liquid is injected into the triboelectric elastomer and the pressure-induced water bridges can modulate the built-in electric field of the sensor, which enhance the signal linearity near the compression limit.

Effect of fluid and driving pressure on cyclical "on-off" flow of pulmonary microcirculation during mechanical ventilation.

Objectives: This study aimed to identify the cyclical "on-off" flow of pulmonary microcirculation during inspiration and expiration by sidestream dark field imaging (SDF) technology in vivo and investigate the effects of volume status and driving pressure on cyclical "on-off" flow of microcirculation.

Methods: 24 ARDS-modeled rabbits were randomly divided into high-driving pressure group (HDP group) and low-driving pressure group (LDP group). Lung microcirculation measurements were performed using the SDF microscope at two timepoints (T1 CVP 2-4 mmHg, T2 CVP 8-10 mmHg).

Association between composite dietary antioxidant index and erectile dysfunction: a cross-sectional study from NHANES.

Background: Individual antioxidants may not fully capture the comprehensive antioxidant intake from an individual's diet. This study utilizes the Complex Dietary Antioxidant Index (CDAI) to evaluate the combined effects of various dietary antioxidants in the diet. The goal is to investigate the relationship between CDAI and the incidence of erectile dysfunction (ED), offering insights for dietary guidelines and intervention strategies aimed at mitigating the burden of ED.

Taming Prolonged Ionic Drift-Diffusion Dynamics for Brain-Inspired Computation.

Recent advances in neural network-based computing have enabled human-like information processing in areas such as image classification and voice recognition. However, many neural networks run on conventional computers that operate at GHz clock frequency and consume considerable power compared to biological neural networks, such as human brains, which work with a much slower spiking rate. Although many electronic devices aiming to emulate the energy efficiency of biological neural networks have been explored, achieving long timescales while maintaining scalability remains an important challenge.

Facile synthesis of defective ZnS-ZnO composite nanosheets for efficient piezocatalytic H production.

A facile approach was developed for the synthesis of ultrathin ZnS-ZnO nanosheets. By simply manipulating the synthesis temperature, ZnS-ZnO composite nanosheets with sulfur vacancies were successfully obtained using ZnS(en) as the precursor. The formation of the ZnS-ZnO composite leads to the creation of a heterojunction at the interface between the two materials, which enhances the separation of piezogenerated electrons and holes.

Giant Piezoelectric Coefficient of Polyvinylidene Fluoride with Rationally Engineered Ultrafine Domains Achieved by Rapid Freezing Processing.

Domains play an essential role in determining the piezoelectric properties of polymers. The conventional method for achieving ultrafine piezoelectric domain structures for polymers is multiphase polymerization, which is not the primary choice for industrial-scale applications because of its complex synthesis and weak mechanical properties. In this study, it is demonstrated for the first time that a nanoscale domain design can be achieved in a commercially available polyvinylidene fluoride (PVDF) homopolymer through a simple fabrication method involving cyclic compression and rapid freezing.

Iron and Nitrogen-Doped Wheat Straw Hierarchical Porous Carbon Materials for Supercapacitors.

In this paper, we prepared a new type of iron and nitrogen co-doped porous carbon material (WSC-Fe/N) using a carbonization-activation process with wheat straw as a precursor and FeCl and NHCl as co-doping agents and analyzed the electrochemical properties of the resulting electrode material. Through precise control of the doping elements and carbonization temperature (900 °C), the resulting WSC-Fe/N-900 material exhibits abundant micropores, uniform mesopores, a significant specific surface area (2576.6 m g), an optimal level of iron doping (1.

Multifunctional nanomaterials composed entirely of active pharmaceutical ingredients for synergistically enhanced antitumor and antibacterial effects.

Introduction: Multifunctional nanomaterials are emerging as promising tools for treating both cancer and bacterial infections. However, integrating dual therapeutic capabilities into a single system remains challenging. This study presents multifunctional nanoparticles (ECI-NPs) based on Epigallocatechin gallate (EGCG) oligomers, Curcumin (CUR), and Indocyanine Green (ICG) for combined cancer and bacterial treatment.

Soft matter mechanics of baseball's Rubbing Mud.

Researchers looking for sustainable materials with optimal mechanical properties may draw inspiration from a baseball tradition. For nearly 100 y, a mysterious mud harvested from an undisclosed river site in New Jersey (USA) has been the agent of choice in the USA's Major League Baseball for "de-glossing" new baseballs. It is unclear, however, what makes this "Rubbing Mud" work.

Comparative transcriptional analyses of the striatum in the chronic social defeat stress model in C57BL/6J male mice and the gut microbiota-dysbiosis model in Kumming mice.

Depression is a complex disorder with multiple contributing factors, and chronic stress has previously been recognized as a major causative factor, while gut microbes have also been found to be involved in depression recently. However, gene expression in depression models with different etiologies is unclear. Here, we compared the transcriptomes of the striatum in chronic social defeat stress (CSDS) model of C57BL/6J male mice and fecal microbiota transplant (FMT) model of Kumming male mice.

Migration patterns of phthalic acid esters from mulch plastic film in the soil-plant-atmosphere continuum system.

Plastic film mulching is an important agricultural practice, but its release of phthalic acid esters (PAEs) poses threats to soil and human health. However, the migration patterns of PAEs during the lifecycle of mulch plastic film (MPF) remain unclear. This study aims to explore the temporal patterns of release of PAEs during the MPF's lifecycle and evaluate the migration patterns of PAEs from MPF in the soil-plant-atmosphere continuum (SPAC) system through pot experiments and model simulations.

Bidirectional influence between benign prostatic hyperplasia, prostate cancer, and prostatitis and mental disorders: two-sample and multivariate mendelian randomization analyses.

Background: We aimed to use Mendelian randomization (MR) to determine the causality between fifteen major mental disorders (MDs) and benign prostatic hyperplasia (BPH), prostate cancer (PCa), and prostatitis.

Methods: The main MR analysis was performed using the inverse variance-weighted (IVW) method.

Results: The study found that insomnia (odds ratio [OR], 1.

Neural and molecular investigation into the paraventricular thalamus for chronic restraint stress induced depressive-like behaviors.

Introduction: Disturbance of neural circuits and chronic stress contribute to depression onset. Given the crucial role of paraventricular nucleus of thalamus (PVT) in emotional behaviors, however, the specific neural and molecular mechanism of PVT in depression still unclear.

Objective: Our study aim to explore the neural and molecular mechanism of PVT in depression.

Impact of back optic zone diameter (BOZD) in orthokeratology on axial length elongation: A meta-analysis and systematic review.

Purpose: Myopia has emerged as a significant public health concern. Recent studies have demonstrated that Orthokeratology (Ortho-K) can effectively decelerate axial length (AL) growth, with eyes possessing smaller back optical zone diameters (BOZD) exhibiting greater effectiveness compared to those with larger BOZD. This study aims to analyze the impact of Ortho-K with varying BOZD.

The Impact of 24 h Urinary Potassium Excretion on High-Density Lipoprotein Cholesterol and Chronic Disease Risk in Chinese Adults: A Health Promotion Study.

Background: Research into the pivotal role of potassium in chronic diseases and their comorbidities remains scarce. Our aim is to elucidate the relationship between potassium and chronic diseases, including comorbid conditions, and to provide evidence-based recommendations for potassium intake in patients.

Methods: This study is anchored in a representative, population-based survey conducted in Zhejiang Province, China, in 2017, encompassing participants aged 18 to 69 years.