Novel Method for Optimization Cement Slurry Based on the Wellbore Integrity Model in High-Temperature and High-Pressure Conditions.

The integrity of the cement sheath is crucial for ensuring the long-term safe and efficient production of oil and gas wells. The mechanical properties of the cement sheath are improved by optimizing the cement slurry to match the actual operating conditions, further enhancing the wellbore integrity. In high-temperature and high-pressure (HTHP) conditions, a mechanics model of casing-cement sheath-formation was developed based on the thick-walled cylinder theory, considering the coupling effect of temperature and pressure as well as elastic and plastic deformation of the cement sheath.

Decoupling analysis and forecast of economic growth from electricity consumption in the Yangtze River Delta region, China.

Decoupling economic growth from electricity consumption is essential for energy conservation and emission reduction. Firstly, this paper applies the LMDI decomposition model to analyze the driving factors of electricity consumption in the Yangtze River Delta region. Secondly, scenario analysis and Monte Carlo technique are combined to research the evolutionary trend of electricity consumption from 2020 to 2035, so as to further analyze the decoupling state.

Case Report: Multiple Organ Failure Caused by Hemorrhagic Fever with Renal Syndrome.

Hemorrhagic fever with renal syndrome (HFRS), a natural epidemic disease caused by hantavirus (HV), is one of the viral diseases that pose a major threat to our health. Considering the increasing number of atypical-onset cases reported in some countries, it is important to be familiar with the symptoms of HFRS and the signs of HV infection. This report describes the case of a 55-year-old man with complaints of fever, vomiting, and diarrhea.

Transcutaneous auricular vagus nerve stimulation reduces cytokine production in sepsis: An open double-blind, sham-controlled, pilot study.

Background: Studies have shown that vagus nerve-mediated inflammatory reflex could inhibit cytokine production and inflammation in sepsis animals.

Objectives: This study aimed to explore the efficacy of transcutaneous auricular vagus nerve stimulation (taVNS) on inflammation and disease severity of sepsis patients.

Methods: A randomized, double-blind, sham-controlled pilot study was performed.

Topological properties of Xene tuned by perpendicular electric field and exchange field in the presence of Rashba spin-orbit coupling.

Xene (X=Si, Ge, Sn) is a typical and promising two-dimensional topological insulator with many novel topological properties. Here, we investigate the topological properties of Xene tuned by a perpendicularly applied electric field, exchange field, and Rashba spin-orbit coupling (RSOC) using the tight-binding (TB) method. We show that in the presence of RSOC, the system can be converted from a quantum spin Hall (QSH) insulator into a conventional band insulator (BI) by a weak perpendicular electric field or into a quantum anomalous Hall (QAH) insulator by a weak exchange field.

A novel choline chloride/graphene composite as a shale inhibitor for drilling fluid and the interaction mechanism.

For wellbore stability in shale formations, the development of environmentally friendly and efficient shale inhibitors is urgently needed. Herein, we report the preparation of choline chloride-modified graphene (Ch-G). The inhibition and interaction mechanisms of choline chloride-modified graphene on montmorillonite were also investigated.

Advanced developments in environmentally friendly lubricants for water-based drilling fluid: a review.

The problem of high friction and high torque is one of the most troublesome problems for engineers in extended reach wells and long horizontal wells. Generally, the friction coefficient of oil-based drilling fluid is around 0.08, while the friction coefficient of water-based drilling fluid exceeds 0.

Taraxasterol Inhibits Hyperactivation of Macrophages to Alleviate the Sepsis-induced Inflammatory Response of ARDS Rats.

To explore the effect and mechanism of taraxasterol on sepsis-induced acute respiratory distress syndrome (ARDS). Twenty-four male SD rats were randomly divided into four groups: the control group, model (lipopolysaccharide, LPS) group, lipopolysaccharide+taraxasterol (LPS + TXL) group, and lipopolysaccharide+ulinastatin (LPS + UTI) group. The model of sepsis-induced ARDS was established by intraperitoneal injection of LPS.

Implications of Withaferin A for the metastatic potential and drug resistance in hepatocellular carcinoma cells via Nrf2-mediated EMT and ferroptosis.

Hepatocellular carcinoma (HCC) constitutes a major global health threat due to the high incidence and mortality. Sorafenib is known as the first-line medication for advanced HCC; however, it only extends the limited benefit for HCC patients as the development of acquired resistance. Withaferin A exerts broad pharmaceutical applications in several cancers.

Bandage contact lens soaked in 0.1% diclofenac to relieve early postoperative pain and foreign body sensation after transepithelial photorefractive keratectomy.

Purpose: To study the effects of a bandage contact lens immersed in 0.1% diclofenac on pain management for patients undergoing transepithelial photorefractive keratectomy (TPRK).

Methods: In a prospective, comparative, contralateral, randomized, double-masked study, we assessed a total of 51 patients.

Chronic Stress Activates PlexinA1/VEGFR2-JAK2-STAT3 in Vascular Endothelial Cells to Promote Angiogenesis.

It is known that chronic stress modulates multiple processes in a complex microenvironment, such as angiogenesis and immune function. However, the role of chronic stress inducing tumor angiogenesis and how it contributes to tumor progression are not quite clear. The following study assess psychological state from numerous ambulatory cancer cases (n=332), and chronic stress-related hormone levels were further measured.

Protectin D1 protects against lipopolysaccharide-induced acute lung injury through inhibition of neutrophil infiltration and the formation of neutrophil extracellular traps in lung tissue.

Protectin D1 (PD1), a DHA-derived lipid mediator, has recently been shown to possess anti-inflammatory and pro-resolving properties. To date, little is known about the effect of PD1 on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice. The aim of the present study was to investigate the therapeutic effects of PD1 on LPS-induced ALI and its potential mechanisms of action.

Polyvinylpyrrolidone (PVP) assisted in-situ construction of vertical metal-organic frameworks nanoplate arrays with enhanced electrochemical performance for hybrid supercapacitors.

Construction of two-dimensional (2D) metal-organic frameworks (MOFs) for energy storage and conversion has attracted great attention due to the synergistic advantages of 2D nanostructures and MOFs. Herein, a Co-MOF material with different 2D morphologies of vertical nanoplate arrays and faveolate nanosheets are in-situ fabricated on Ni foam with and without using polyvinylpyrrolidone (PVP) as a regulator. Toward the application in energy storage, both of two morphologies of the Co-MOF exhibit good electrochemical properties.

Thymosin alpha 1 in the prevention of infected pancreatic necrosis following acute necrotising pancreatitis (TRACE trial): protocol of a multicentre, randomised, double-blind, placebo-controlled, parallel-group trial.

Introduction: Infected pancreatic necrosis (IPN) and its related septic complications are the major causes of death in patients with acute necrotising pancreatitis (ANP). Therefore, the prevention of IPN is of great clinical value, and immunomodulatory therapy with thymosin alpha 1 may be beneficial. This study was designed to test the hypothesis that the administration of thymosin alpha 1 during the acute phase of ANP will result in a reduced incidence of IPN.

Intrinsic enzyme-like activity of magnetite particles is enhanced by cultivation with Trichoderma guizhouense.

Fungal-mineral interactions can produce large amounts of biogenic nano-size (~ 1-100 nm) minerals, yet their influence on fungal physiology and growth remains largely unexplored. Using Trichoderma guizhouense NJAU4742 and magnetite (Mt) as a model fungus and mineral system, we have shown for the first time that biogenic Mt nanoparticles formed during fungal-mineral cultivation exhibit intrinsic peroxidase-like activity. Specifically, the average peroxidase-like activity of Mt nanoparticles after 72 h cultivation was ~ 2.

Mechanisms of potentially toxic metal removal from biogas residues via vermicomposting revealed by synchrotron radiation-based spectromicroscopies.

Biogas residues (BR) contaminated with potentially toxic metals pose environmental risks to soils and food chains, and strategies are needed to decrease the concentration and bioavailability of potentially toxic metals in BR. Here, metal fractions and removal mechanisms were quantified by synchrotron radiation-based Fourier transform infrared and micro X-ray fluorescence spectromicroscopies on BR and earthworms subject to vermicomposting. Vermicomposting resulted in decreases in concentrations of potentially toxic metals in BR and increases in metal removal efficiencies due to uptake by earthworms.

A Prospective Randomized Trial to Assess the Antireflux Effect of Antireflux Mucosectomy in the Porcine Model.

Background: Both long-term proton pump inhibitor use and surgical fundoplication have potential drawbacks as treatments for chronic gastroesophageal reflux disease (GERD). Our aim was to investigate the potential efficacy of antireflux mucosectomy (ARMS) in porcine and determine the optimal circumference of resection in relation to gastroesophageal junction (GEJ).

Methods: Nine pigs were allocated into the following 3 groups by computerized randomization: group A: control, group B: 1/3 circumference of the esophagus, and group C: 2/3 circumference of the esophagus.

MiR-20a Plays a Key Regulatory Role in the Repair of Spinal Cord Dorsal Column Lesion via PDZ-RhoGEF/RhoA/GAP43 Axis in Rat.

Spinal cord injury (SCI) causes sensory dysfunctions such as paresthesia, dysesthesia, and chronic neuropathic pain. MiR-20a facilitates the axonal outgrowth of the cortical neurons. However, the role of miR-20a in the axonal outgrowth of primary sensory neurons and spinal cord dorsal column lesion (SDCL) is yet unknown.

Isoprenaline/β2-AR activates Plexin-A1/VEGFR2 signals via VEGF secretion in gastric cancer cells to promote tumor angiogenesis.

Background: The role of stress signals in regulating gastric cancer initiation and progression is not quite clear. It is known that stress signals modulate multiple processes such as immune function, cell migration and angiogenesis. However, few studies have investigated the mechanisms of how stress signals contribute to gastric cancer angiogenesis.

Bevacizumab and risk of intracranial hemorrhage in patients with brain metastases: a meta-analysis.

Administration of bevacizumab to patients with brain metastases (BM) is controversial due to concerns about the increased risk of intracranial hemorrhage (ICH). This meta-analysis assessed whether the risk of ICH increases in BM patients receiving treatments that contain bevacizumab versus without. PubMed, Embase, Cochrane Library and annual meeting abstracts of the American Society of Clinical Oncology up to 13 November 2016 were searched for studies that referred to ICH complications due to bevacizumab in patients with BM.

Expression of semaphorin 6D and its receptor plexin-A1 in gastric cancer and their association with tumor angiogenesis.

The semaphorin and plexin family of ligands and receptor proteins provides important axon growth and guidance cues required for development. In recent years, studies have expanded their role in the regulation of cardiac morphogenesis and tumorigenesis. However, the mechanism responsible for their role in regulating cancer development and progression has not been clarified.

Genome analysis revealed novel genotypes and recombination of the human parechoviruses prevalent in children in Eastern China.

Background: Human parechovirus (HPeV) is a genus of virus in the family , having two species A and B. HPeVs are common infectious agents, usually causing mild diarrhea and respiratory disease in young children.

Results: Here, we collected and sequenced the near complete genome sequences of 17 novel HPeVs from children with diarrhea in eastern China, which showed significant nucleotide sequence divergence.

Isoprenaline induces epithelial-mesenchymal transition in gastric cancer cells.

The emerging role of stress-related signaling in regulating cancer development and progression has been recognized. However, whether stress serves as a mechanism to promote gastric cancer metastasis is not clear. Here, we show that the β2-AR agonist, isoprenaline, upregulates expression levels of CD44 and CD44v8-10 in gastric cancer cells.