A novel peroxisome-related gene signature predicts clinical prognosis and is associated with immune microenvironment in low-grade glioma.

Low-grade glioma (LGG), a common primary tumor, mainly originates from astrocytes and oligodendrocytes. Increasing evidence has shown that peroxisomes function in the regulation of tumorigenesis and development of cancer. However, the prognostic value of peroxisome-related genes (PRGs) in LGG has not been reported.

Porous Cobalt Sulfide Selenium Nanorods for Electrochemical Hydrogen Evolution.

A key process in electrochemical energy technology is hydrogen evolution reaction (HER). However, its electrochemical properties mainly depend on the catalytic activity of the material itself. Therefore, it is important to find efficient electrocatalysts to realize clean hydrogen production.

MicroRNA-4491 enhances cell proliferation and inhibits cell apoptosis in non-small cell lung cancer via targeting TRIM7.

MicroRNAs (miRNAs) are involved in the development of non-small cell lung cancer (NSCLC). However, the biological roles of several aberrantly expressed miRNAs have not been explored yet. In the present study, miR-4491 was identified as a novel upregulated miRNA in NSCLC tissues and cell lines.

Interface engineering of cobalt-sulfide-selenium core-shell nanostructures as bifunctional electrocatalysts toward overall water splitting.

The number of active sites and stability of the structure of electrocatalysts are the key factors in the process of overall water splitting. In this paper, cobalt-sulfide-selenium (Se:CoS) core-shell nanostructures are prepared by a simple two-step method, including hydrothermal reaction and chemical vapor deposition. The resulting product exhibits excellent electrochemical performance, owing to the synergistic effects between CoS and CoSe, as well as the plentiful active sites in the electrode structure.

Nonatrial Fibrillation Patients With Complete P Wave Disappearance: An Overlooked Population With High Stroke Risk.

Background And Purpose: Complete P wave disappearance (CPWD) in patients without atrial fibrillation is an uncommon clinical phenomenon. We aimed to study the relationship between CPWD and thromboembolism.

Methods: Between July 2007 and December 2018, consecutive patients with CPWD on surface ECG and 24-hour Holter recording were recruited into the study from 4 centers in China.

Graphene-based electrically controlled terahertz polarization switching between a quarter-wave plate and half-wave plate.

We theoretically present a high-efficiency switchable reflective terahertz polarization converter composed of a periodic array of rectangular-shaped metal-dielectric-graphene sandwich structure on a dielectric substrate supported by a thick metallic film. Graphene sheet together with the rectangular-shaped metal patch provides tunable anisotropic hybrid magnetic plasmon resonance to obtain tunable phase delay of 90° and 180°, corresponding to a quarter-wave plate (QWP) and half-wave plate (HWP), respectively. Results of numerical simulations indicate that the proposed structure can switch functions between a QWP and HWP at a certain frequency simply by adjusting the Fermi energy of graphene.

Graphene-enabled electrically tunability of metalens in the terahertz range.

In general, the functions of most metalenses cannot be adjusted dynamically after being fabricated. Here, we theoretically propose an electrically tunable metalens composed of single-layered and non-structured doped graphene loaded with ribbon-shaped metallic strip arrays with varied widths and gaps. The combination of the different widths and gaps can provide full phase coverage from 0 to 2π, which is necessary for a plane wave to be focused.

Initiating TrkB/Akt Signaling Cascade Preserves Blood-Brain Barrier after Subarachnoid Hemorrhage in Rats.

The integrity of the blood-brain barrier (BBB) plays a vital role in affecting the prognosis of subarachnoid hemorrhage (SAH). This study aimed to investigate activation of the Tropomyosin-related kinase receptor B (TrkB) and its downstream signaling pathway on preserving BBB breakdown after experimental SAH. An endovascular perforation SAH model was applied.

Multimodality Imaging for Navigation in Endoscopic Transsphenoidal Surgeries.

Background And Study Aims:  Computed tomography (CT) and magnetic resonance image (MRI) data have been widely used to for navigation in various neurosurgical operations. However, delicate intracranial structures cannot be displayed using only one imaging method. Navigation with multimodality imaging was developed to better visualize these structures in glioma removal, but whether it is useful in endoscopic transsphenoidal surgery is unknown.

Comparison of everolimus-eluting bioresorbable vascular scaffolds and metallic stents: three-year clinical outcomes from the ABSORB China randomised trial.

Aims: Absorb bioresorbable vascular scaffolds (BVS) and XIENCE cobalt-chromium everolimus-eluting stents (CoCr-EES) had comparable angiographic and clinical outcomes up to one year in patients enrolled in the ABSORB China randomised trial. Whether these favourable results with BVS continue beyond one year up to three years is unknown. In this study we sought to analyse the outcomes from the trial up to three-year follow-up.

25-Hydroxy vitamin D level is associated with total MRI burden of cerebral small vessel disease in ischemic stroke patients.

Background: Decreased 25-hydroxyvitamin D [25(OH)D] has been reported to be related to increased risk of cerebrovascular disease. We aimed to investigate whether an association exists between 25(OH)D levels and cerebral small vessel disease (cSVD).

Method: Patients with first-ever minor ischemic stroke or transient ischemic attack were recruited prospectively during Jan 2017 to December 2017.

Transcription factor PU.1 is involved in the progression of glioma.

Glioma is a severe disease of the central nervous system. Although previous studies have identified the important role of the immune response in association with tumor intervention, it is still unknown whether PU.1, a transcription factor known for its role in myeloid differentiation and immune responses, is involved in the progression of glioma.

MicroRNA-24 inhibits the proliferation and migration of endothelial cells in patients with atherosclerosis by targeting importin-α3 and regulating inflammatory responses.

The aim of the present study was to measure the level of microRNA (miRNA or miR)-24 in the serum of patients with atherosclerosis and to investigate the effect of miR-24 on the expression of importin-α3 and tumor necrosis factor (TNF)-α, as well as the proliferation and migration of vascular endothelial cells. A total of 30 patients with atherosclerosis admitted to hospital between January and June 2016 were enrolled in the present study; 30 healthy subjects with a similar age range were enrolled as controls. Peripheral blood (10 ml) was collected from all participants.

Association Between PM Exposure and the Prognosis of Patients with Acute Myocardial Infraction.

Background: Numerous case-crossover and time series studies of PM exposure and cardiovascular health effects have been conducted, fever studies have examined the effects of PM on the outcomes of CHD, especially on acute myocardial infarction (AMI).

Objective: The objective of this research is to investigate the association between PM exposure in Tianjin City and the outcome of AMI.

Methods: We conducted a retrospective analysis of a total of 598 patients with AMI in TEDA International Cardiovascular Hospital, from Oct 28th, 2013-Apr 30th 2014.

Low Serum-Butyrylcholinesterase Activity as a Prognostic Marker of Mortality Associates with Poor Cardiac Function in Acute Myocardial Infarction.

Background: Recently, butyrylcholinesterase (BChE) activity seems to have an independent prognostic role in acute coronary syndrome (ACS). However, the underlying mechanisms remain unclear. A previous study showed that serum BChE activity had a diagnostic value for chronic heart failure.

Curcumin Downregulates Phosphate Carrier and Protects against Doxorubicin Induced Cardiomyocyte Apoptosis.

Aim. To explore the effects of curcumin on phosphate carrier (PiC) and its role in protection against doxorubicin induced myocyte toxicity. Methods.

Comparison on the efficacy of everolimus-eluting stent and zotarolimus-eluting stents in coronary heart disease between diabetic and non-diabetic patients.

Objective: The aim of this study is to examine and compare the efficacy of everolimus-eluting stents (EES) and zotarolimus-eluting stents (ZES) in coronary heart disease in diabetic or non-diabetic patients.

Methods: A total of 666 patients needed for percutaneous coronary intervention were randomly selected from June 2008 to June 2013 in our hospital and were divided into two groups: (i) coronary heart disease with diabetes group and (ii) non-diabetes group. Patients in each group were further assigned to receive treatment of either EES or ZES.

Therapeutic efficacy of a polysaccharide isolated from Cordyceps sinensis on hypertensive rats.

This study was aimed to investigate the antihypertensive effect of a polysaccharide fraction from Cordyceps sinensis on spontaneously hypertensive rats (SHR). The CSP1, one component of Cordyceps sinensis polysaccharides (CSP), was obtained after water extraction, deproteinization, de-colorization and purification with DEAE-cellulose 52. And a more homogeneous component CSP1-2 was obtained using Sepharose CL-6B chromatography.

Analysis of the embolization spinal dural arteriovenous fistula and surgical treatments on 52 cases of the patients.

Background: Spinal dural arteriovenous fistula (SDAVF) highly threatens people's life and health. Effective methods for the diagnosis and treatment of the disease are badly needed in clinical application.

Objective: The objective of the present study was to sum up the diagnosis and treatment method of SDAVF to improve the diagnosis and treatment effect of the disease.

Heptanol decreases the incidence of ischemia-induced ventricular arrhythmias through altering electrophysiological properties and connexin 43 in rat hearts.

Heptanol is a type of gap junction inhibitor that decreases electrical conduction velocity. However, little is known regarding the effects of heptanol on the arrhythmias induced by regional myocardial ischemia. This study aimed to investigate the effects of heptanol on ventricular arrhythmias and the underlying mechanisms.

Clinical review: Efficacy of antimicrobial-impregnated catheters in external ventricular drainage - a systematic review and meta-analysis.

To assess the efficacy of antimicrobial-impregnated catheters in preventing catheter-related infections during external ventricular drainage (EVD), we performed a meta-analysis and systematic review. We systematically searched Medline, Embase, and the Cochrane Library. All randomized controlled trials (RCTs) and nonrandomized prospective studies (NPSs) related to antimicrobial-impregnated EVD catheters were included.

Cholesterol levels and risk of hemorrhagic stroke: a systematic review and meta-analysis.

Background And Purpose: Cholesterol levels are inconsistently associated with the risk of hemorrhagic stroke. The purpose of this study is to assess their relationships using a meta-analytic approach.

Methods: We searched PubMed and Embase for pertinent articles published in English.