Bilateral Unsymmetrical Disulfurating Reagent Design for Polysulfide Construction.

Polysulfides are significant compounds in life science, pharmaceutical science, and materials science. Therefore, polysulfide construction is in great demand. The controllable sequential installation of groups on both ends of a S-S motif faces an enormous challenge owing to the reversible nature of the covalent S-S bond.

Numerical investigation on the ranging performance of forward pulsed laser radar affected by shock waves.

When an aircraft loaded with pulsed laser radar flies at supersonic speed, the laser beam will be distorted by the uneven outflow field, resulting in a significant reduction in ranging accuracy. In this study, the influence mechanism of the shock wave on the performance of forward pulsed laser radar is investigated. First, a novel semi-analytical method is proposed to model the pulsed laser echo wave affected by shock waves, which combines the laser radar equation with optical distortion parameters.

Iodine-Mediated Domino Cyclization for One-Pot Synthesis of Indolizine-Fused Chromones via Metal-Free sp C-H Functionalization.

An efficient method for the synthesis of new indolizine-fused chromones has been accomplished from ethyl ()-3-(2-acetylphenoxy)acrylates and pyridines in a "one-pot" manner. Facile operation in open-air, metal-free, and mild conditions renders this protocol particularly practical and attractive. Moreover, this method can simultaneously construct two molecular fragments of chromone and indolizine.

Cascade Wolff Rearrangement/Acylation: A Metal-Free and Eco-Friendly Approach for 4-Hydroxy-pyrazolo[3,4-]pyridin-6-ones and -Pyrazole Amides Synthesis from 5-Aminopyrazoles and α-Diazoketones.

A highly chemoselective cascade Wolff rearrangement/acylation reaction between 5-aminopyrazoles and diazo compounds has been developed. The protocol can facilitate the switchable synthesis of 4-hydroxy-pyrazolo[3,4-]pyridin-6-ones and -pyrazole amides with the merits of a broad substrate scope, high functional group compatibility, and green and sustainable performance manner. All reactions proceeded efficiently without any catalyst and additives (acid and base) and resulted in the release of benign N, wherein diethyl carbonate served as a green benign solvent.

One-Pot Synthesis of Chromone-Fused Pyrrolo[2,1-]isoquinolines and Indolizino[8,7-]indoles: Iodine-Promoted Oxidative [2 + 2 + 1] Annulation of -Acetylphenoxyacrylates with Tetrahydroisoquinolines and Noreleagnines.

An iodine-promoted one-pot cascade oxidative annulation reaction has been developed for the synthesis of chromone-fused-pyrrolo[2,1-]isoquinolines and indolizino[8,7-]indoles from -acetylphenoxyacrylates, tetrahydroisoquinolines, and noreleagnines. This process underwent a logical approach to both chromone-fused-pyrrolo[2,1-]isoquinolines and chromone-fused-indolizino[8,7-]indoles isolamellarin derivatives. Manipulations of l-menthol and dl-α-tocopherol demonstrate the applications of this strategy.

The Involvement of Metals in Alzheimer's Disease Through Epigenetic Mechanisms.

Alzheimer's disease (AD) is the most frequent cause of dementia among neurodegenerative diseases. Two factors were hypothesized to be involved in the pathogenesis of AD, namely beta-amyloid cascade and tauopathy. At present, accumulating evidence suggest that epigenetics may be the missing linkage between genes and environment factors, providing possible clues to understand the etiology of the development of AD.

Fabrication of resorcinol-based porous resin carbon material and its application in aqueous symmetric supercapacitors.

Carbon materials with porous structures with their unique surface area and charge transport properties have been attracting significant attention as electrode materials in renewable energy storage devices. The rapid agglomeration of layered materials during electrochemical processes reduces their shelf life and specific capacitance, which can be prevented by the introduction of suitable pores between the layers. In this study, resorcinol-based porous resin carbon was facilely prepared a simple carbonization of the potassium salts of resorcinol-potassium resin.