Publications by authors named "XiangHong Zhou"
Background And Objectives: Randomized trials have proven the benefit of endovascular therapy (EVT) for acute large ischemic stroke. This study was to characterize the effect of time to treatment on benefit of EVT vs medical management (MM) among patients with large ischemic stroke.
Methods: This was a post hoc analysis of the Endovascular Therapy in Acute Anterior Circulation Large Vessel Occlusive Patients with a Large Infarct Core randomized trial.
Article Synopsis
- Urinary incontinence (UI) and erectile dysfunction (ED) are common complications after robotic-assisted radical prostatectomy (RARP) for prostate cancer, impacting patients' quality of life (QoL).
- The study analyzed preoperative clinical data and MRI parameters from 627 prostate cancer patients treated between January 2018 and September 2022 to create predictive models for postoperative UI and ED.
- Key predictors identified for urinary continence and sexual function included age, clinical stage, Gleason score, and various anatomical measurements, which can help guide treatment decisions and improve patient outcomes.
Article Synopsis
- - The study investigates the link between using solid fuel for household energy and experiencing lower urinary tract symptoms (LUTS) indicative of benign prostatic hyperplasia (BPH) among older Chinese men, highlighting that over half of men aged 70 and older may be affected by BPH.
- - Utilizing data from the West China Natural Population Cohort Study, researchers found a significant positive correlation between solid fuel use and LUTS/BPH, with participants using solid fuel nearly twice as likely to report symptoms compared to those using clean fuel.
- - Further analysis revealed that non-smoking and non-drinking individuals had a higher odds ratio for LUTS/BPH when using solid fuels, suggesting lifestyle factors may influence the severity of symptoms associated with
Background: As the human body ages, adverse body composition status such as sarcopenia and obesity become obvious phenotypes which can cause numerous health problems. We aimed to comprehensively investigate the association of sex hormones and body mass components in adult men of various age groups.
Methods: We analysed national representative population data from the US National Health and Nutrition Examination Survey.
Cardiovascular disease remains the leading cause of death worldwide, with air pollution's impact on cardiovascular health being closely monitored. However, the specific effects of air pollution on the risk of hospital readmission for heart failure (HF) in patients with unstable angina (UA) have not been fully explored. We conducted a retrospective study involving 12,857 consecutive patients diagnosed with acute coronary syndrome (ACS) between January 2015 and March 2023.
View Article and Find Full Text PDFRobot-assisted surgery has evolved into a crucial treatment for prostate cancer (PCa). However, from its appearance to today, brain-computer interface, virtual reality, and metaverse have revolutionized the field of robot-assisted surgery for PCa, presenting both opportunities and challenges. Especially in the context of contemporary big data and precision medicine, facing the heterogeneity of PCa and the complexity of clinical problems, it still needs to be continuously upgraded and improved.
View Article and Find Full Text PDFBackground: Stroke etiology could influence the outcomes in patients with basilar-artery occlusion (BAO). This study aimed to evaluate the differences in efficacy and safety of best medical treatment (BMT) plus endovascular treatment (EVT) versus BMT alone in acute BAO across different stroke etiologies.
Methods: The study was a post hoc analysis of the ATTENTION trial (Trial of Endovascular Treatment of Acute Basilar-Artery Occlusion), which was a multicenter, randomized trial at 36 centers in China from February 2021 to September 2022.
Endocrine-disrupting chemicals (EDCs) are persistent and pervasive compounds that pose serious risks. Numerous studies have explored the effects of EDCs on human health, among which tumors have been the primary focus. However, because of study design flaws, lack of effective exposure levels of EDCs, and inconsistent population data and findings, it is challenging to draw clear conclusions on the effect of these compounds on tumor-related outcomes.
View Article and Find Full Text PDFObjective: To analyze the clinical features and laboratory indicators in patients with solid malignant tumor-associated venous thromboembolism (Ta-VTE), and to study the risk factors for Ta-VTE.
Methods: The hospitalized patients with VTE in Guizhou Provincial People's Hospital from January to December 2020 were enrolled, and they were divided into Ta-VTE group and pure VTE group based on the presence or absence of solid malignant tumor. The differences in clinical data and laboratory indicators between the two groups were analyzed, and the indicators with significant differences were included in logistic regression model to analyze the risk factors of Ta-VTE.
Article Synopsis
- Researchers developed a UPLC-MS/MS method to analyze bisphenol and phthalate metabolites in urine, focusing on their link to prostate cancer (PCa) through a case-control study.
- The method showed high effectiveness in detecting metabolites, achieving nearly 100% detection rates for bisphenol A and most phthalate metabolites, while highlighting varying exposure levels among participants.
- Logistic regression analysis indicated that exposure to bisphenol A and di(2-ethylhexyl) phthalate significantly increases the risk of developing prostate cancer, with odds ratios of 10.02 and 48.26, respectively.
Background: Testicular cancer (TC) is currently the most common malignancy in young and middle-aged men. A comprehensive assessment of TC burden is in lack.
Method: Global incidence, deaths, and disability-adjusted life-years (DALYs) of TC from 1990 to 2019 were obtained.
Article Synopsis
- Cancer immunotherapy using autologous CAR T cells is complicated by manufacturing and patient selection issues, but 'off-the-shelf' options like allogeneic CAR-NKT cells could simplify the process.
- Researchers developed a new method to produce high-yield IL-15-enhanced CAR-NKT cells that target multiple cancers, showing effectiveness in battling multiple myeloma and removing immunosuppressive cells from tumors.
- The CAR-NKT cells demonstrated a stable hypoimmunogenic profile, meaning they are less likely to cause harmful immune reactions, making them promising candidates for clinical use without severe side effects like graft versus host disease.
Introduction: Previous studies showed exercise have efficacies for androgen deprivation therapy (ADT) adverse effects. To compare the efficacies of different exercises on ADT adverse effects, we conducted the network meta-analysis (NMA).
Methods: Literature retrieval was performed in PubMed, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL).
Introduction: Although previous studies investigated the potential adverse effects of endocrine-disrupting chemicals (EDCs) on biological age acceleration and aging-related diseases, the mixed effect of multiple types of EDCs on biological age acceleration, including its potential underlying mechanism, remains unclear.
Methods: Data from the National Health and Nutrition Examination Survey (NHANES) were used to analyze biological age measures, including Klemera-Doubal method biological age (KDM-BA), phenotypic age, and homeostatic dysregulation (HD). Weight quantile sum (WQS) regression was performed to screen biological age-related EDCs (BA-EDCs) and assess the mixed effect of BA-EDCs on biological age acceleration and aging-related disease.
Article Synopsis
- Deep learning is being used in medicine, but its interpretability is a major challenge, particularly for predicting continence in prostate cancer patients post-surgery.
- Captum is a tool that helps interpret neural network models by assessing feature importance, yet it's not widely applied in medical contexts.
- The study identified key anatomical MRI measurements predicting continence with high accuracy, offering valuable insights for clinical applications and demonstrating the usefulness of interpretable deep learning models in healthcare.
The nuclear folding of chromosomes relative to nuclear bodies is an integral part of gene function. Here, we demonstrate that population-based modeling-from ensemble Hi-C data-provides a detailed description of the nuclear microenvironment of genes and its role in gene function. We define the microenvironment by the subnuclear positions of genomic regions with respect to nuclear bodies, local chromatin compaction, and preferences in chromatin compartmentalization.
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- Plasma cell-free DNA (cfDNA) serves as a noninvasive biomarker for identifying cell death across different organs, which can help in detecting and monitoring diseases.
- The study presents a comprehensive tissue methylation atlas created from 521 noncancer samples, identifying specific methylation patterns that aid in accurately determining the tissue origin of cfDNA.
- A new deep-learning model called supervised tissue deconvolution is developed, which shows improved sensitivity and accuracy for analyzing cfDNA, with applications in disease diagnosis and tracking treatment effects.
Background: Bladder cancer, characterized by a high potential of tumor recurrence, has high lifelong monitoring and treatment costs. To date, tumor cells with intrinsic softness have been identified to function as cancer stem cells in several cancer types. Nonetheless, the existence of soft tumor cells in bladder tumors remains elusive.
View Article and Find Full Text PDFSome evidence have suggested that various nutrients and inflammatory factors might influence the lower urinary tract function. However, the correlation between diet and urinary flow rate (UFR) is not clear. Our study aimed to evaluate the association between the dietary inflammatory index (DII) and UFR.
View Article and Find Full Text PDFBackground: DOK3 (Downstream of kinase 3) is involved primarily with immune cell infiltration. Recent research reported the role of DOK3 in tumor progression, with opposite effects in lung cancer and gliomas; however, its role in prostate cancer (PCa) remains elusive. This study aimed to explore the role of DOK3 in PCa and to determine the mechanisms involved.
View Article and Find Full Text PDFThe association between sex hormones and periodontitis among American adults: A cross-sectional study.
Front Endocrinol (Lausanne)
March 2023
Introduction: After adulthood, as a person grows older, the secretion of sex hormones in the body gradually decreases, and the risk of periodontitis increases. But the relationship between sex hormones and periodontitis is still controversial.
Methods: We investigated the association between sex hormones and periodontitis among Americans over 30 years old.
Article Synopsis
- Cell-free DNA (cfDNA) from blood can be used for cancer diagnosis, treatment guidance, and monitoring, but detecting mutations in cfDNA is difficult due to low tumor levels.
- The new computational method cfSNV has been developed to more effectively identify these mutations in cfDNA, outperforming traditional methods that only work well with solid tumor samples.
- The user-friendly cfSNV package allows researchers, even those with limited computational skills, to analyze cfDNA efficiently on both local and high-performance computing systems, with mutation detection taking about 3 hours on a capable server.