Bioinformatics-based screening and analysis of the key genes involved in the influence of antiangiogenesis on myeloid-derived suppressor cells and their effects on the immune microenvironment.

This study aimed to screen differentially expressed genes (DEGs) involved in the influence of antiangiogenic therapy on myeloid-derived suppressor cell (MDSC) infiltration and investigate their mechanisms of action. Data on DEGs after the action of antiangiogenic drugs in a pan-cancer context were obtained from the Gene Expression Omnibus (GEO) database. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed using the clusterProfiler package in R software.

Hepatic arterial infusion chemotherapy combined with bevacizumab plus a PD-1 inhibitor for gallbladder cancer with hepatic oligometastasis: a real-world study.

Background: Gallbladder cancer (GBC) is different from other biliary tract cancers in terms of molecular phenotype and microenvironment. Specific treatments for GBC need to be urgently explored. This study preliminarily investigated the clinical value of hepatic artery infusion chemotherapy (HAIC) combined with bevacizumab plus a programmed death receptor-1 (PD-1) inhibitor for treatment of GBC with hepatic oligometastasis.

Acylhydrazone functionalized naphthalene-based self-assembled supramolecular gels for efficient fluorescence detection of Fe.

A new gel factor (named N) has been successfully designed and synthesized, which contains the conventional fluorophore naphthalene with the acylhydrazone bond as the self-assembly site. It can be self-assembled into stable organogels (named ON) in dimethyl sulfoxide (DMSO) and water mixed medium ( :  = 4 : 1) with a critical gel temperature and concentration (55 °C and 10 mg mL). Interestingly, under 365 nm UV light, the ON exhibits bright yellow Aggregation Induced Emission (AIE).

Flame-Retardant Foamed Material Based on Modified Corn Straw Using Two Nitrogenous Layers.

Foamed materials based on a biopolymer of crop straws are environmentally friendly, but ignitability limits their application. In this study, two nitrogenous layers were introduced onto corn straw by esterification and grafting for flame-retardant purposes. The inner thin nitrogenous layer consisted of imidazole rings, and the outer thick nitrogenous layer consisted of grafted acrylamide by a free-radical polymerization.

Treatment of neurofibromatosis type II with anlotinib: a case report and literature review.

Patients with neurofibromatosis type II (NF2) usually require surgical treatment, but the probability of tumor recurrence remains high after surgical resection. Moreover, because most of NF2 lesions involve the facial nerve, the risk of facial nerve injury during the surgery is high. Stereotactic radiotherapy can be used to treat some cases of NF2.

Anlotinib reduces the suppressive capacity of monocytic myeloid-derived suppressor cells and potentiates the immune microenvironment normalization window in a mouse lung cancer model.

By exploring the effects of an antiangiogenic small molecule drug named anlotinib on the levels of myeloid-derived suppressor cells (MDSCs) in a mouse xenograft model of lung cancer, the role of anti-angiogenesis in remodeling the immune microenvironment was discussed. In addition, the impact of anlotinib on the normalization of the immune microenvironment and time window was examined, providing a theoretical basis for the optimization of clinical strategies applying anlotinib combined with PD-1 inhibitors. On the basis of the LLC mouse xenograft model, MDSCs and MDSCs + immune microenvironment were examined in tissues, respectively, according to different samples.

Preparation of Boron/Sulfur-Codoped Porous Carbon Derived from Biological Wastes and Its Application in a Supercapacitor.

Abundant biomass resources are a good choice for preparing electrode materials for supercapacitors, but developing a versatile and simple synthetic method to convert them into electrode materials remains a challenge. In the present research, our team reports a promising strategy and cost-efficient method to fabricate boron/sulfur-codoped porous carbon from biomass sources, mainly utilizing four biomass materials. Detailed material characterization showed that the samples produced by this approach possess rich B and S doping.

Induction of ligustrazine apoptosis of A549 cells through activation of death receptor pathway.

Background: The aim of this study was to evaluate the effect of ligustrazine on the apoptosis of A549 cells and clarify the mechanism of ligustrazine-induced apoptosis.

Methods: Ligustrazine was prepared with medium according to the gradient concentration. Based on a cytotoxicity test, 3 different concentrations of ligustrazine were selected to form low, medium, and high groups, with a 0 mg/mL dose used as the control.

Oocyte Penetration Speed Optimization Based on Intracellular Strain.

Oocyte penetration is an essential step for many biological technologies, such as animal cloning, embryo microinjection, and intracytoplasmic sperm injection (ICSI). Although the success rate of robotic cell penetration is very high now, the development potential of oocytes after penetration has not been significantly improved compared with manual operation. In this paper, we optimized the oocyte penetration speed based on the intracellular strain.

A Cell's Viscoelasticity Measurement Method Based on the Spheroidization Process of Non-Spherical Shaped Cell.

The mechanical properties of biological cells, especially the elastic modulus and viscosity of cells, have been identified to reflect cell viability and cell states. The existing measuring techniques need additional equipment or operation condition. This paper presents a cell's viscoelasticity measurement method based on the spheroidization process of non-spherical shaped cell.

Functionalized nano-starch prepared by surface-initiated atom transfer radical polymerization and quaternization.

Functionalized nano-starch particles, designed for the adsorption of heavy metals in wastewater, were prepared by a nano-processing, a halogenated grafting modification, a grafting copolymerization of surface-initiated atom transfer radical polymerization (SI-ATRP) and a quaternized modification of native corn starch. The influence of the synthesis process variables, such as the hydrolysis time, the concentration of monomer, the molar ratio of copper bromide (CuBr) to 2, 2'-bipyridine (bpy) and the graft copolymerization temperature on the properties of the products were studied. The morphology, molecular structure, crystalline structure of the functionalized nano-starch and its derivatives were characterized by Fourier transform-infrared spectroscopy (FT-IR), H nuclear magnetic resonance (H-NMR) spectroscopy, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and transmission electron microscope (TEM).

Abscopal effect of radiation on lymph node metastasis in esophageal carcinoma: A case report and literature review.

The Abscopal effect is a rare phenomenon observed in the treatment of metastatic cancer, where localized irradiation causes a response in non-irradiated tumor sites. Due to the recent success of immunotherapies, the Abscopal effect of radiation therapy has received renewed clinical interest. However, there is limited knowledge regarding the Abscopal effect and radiotherapy treatment of patients with esophageal carcinoma.

Environment-friendly urea-oxidized starch adhesive with zero formaldehyde-emission.

This study reports on an environment-friendly renewable and zero formaldehyde-emission urea-oxidized starch (U-OSt) adhesive based on native corn starch. The adhesive was prepared by polycondensation reaction of oxidized starch and urea. The morphology, molecular structure, crystalline structure, shear strength and viscosity of the adhesive, the native and oxidized starch were instrumentally investigated.

Overexpression of B7-H3 correlates with aggressive clinicopathological characteristics in non-small cell lung cancer.

Previous studies have investigated the prognostic significance of B7 homolog 3 (B7-H3) in non-small cell lung cancer (NSCLC), however, the results remain controversial. This study was aimed to determine the correlation between B7-H3 and survival as well as clnicalpathological characteristics in NSCLC using meta-analysis. We searched the electronic databases of PubMed, Embase, Web of Science, and China National Knowledge Infrastructure (CNKI) for relevant studies up to October 9, 2016.

Metabolism-related enzyme alterations identified by proteomic analysis in human renal cell carcinoma.

The renal cell carcinoma (RCC) is one of the most common types of kidney neoplasia in Western countries; it is relatively resistant to conventional chemotherapy and radiotherapy. Metabolic disorders have a profound effect on the degree of malignancy and treatment resistance of the tumor. However, the molecular characteristics related to impaired metabolism leading to the initiation of RCC are still not very clear.

Clinical value of F-fluorodeoxyglucose positron emission tomography/computed tomography in evaluating relapsed and refractory nasopharyngeal carcinoma: A case report.

For patients with locoregionally advanced nasopharyngeal carcinoma (NPC), radiotherapy, chemotherapy and even targeted therapy are widely accepted treatments. These treatments, although they mostly achieve locoregional tumor control, they may also be associated with complex post-treatment changes, such as edema, loss of tissue planes, fibrosis, mucositis and scarring, which may interfere with the detection of local recurrence and the response to therapy. However, timely detection is crucial for deciding whether treatment modification or discontinuation is required.

Growth inhibitory effect of adenovirus-mediated tissue-targeted expression of ribosomal protein L23 on human colorectal carcinoma cells.

A large body of evidence has established murine double minute 2 (MDM2) as a crucial negative regulator of p53 and the major suppressor of p53 function in tumors with wild-type (wt)-p53. Therefore, by inhibiting MDM2 one may reactivate p53 in tumor cells, leading to their demise. Previous studies revealed that ribosomal protein L23 (RPL23) inhibited MDM2-mediated p53 ubiquitination through direct binding to MDM2, and subsequently induced the p53 level as well as its activity, suggesting that it may be a candidate for use in tumor gene therapy.

[Clinical examples of professor LI Zhi-dao's "tonifying three qi" acupuncture method].

Professor LI Zhi-dao, according to acupoint selection of syndrome differentiation in TCM basic theory, concluded a new therapy, namely "tonifying three qi" that is mainly based on three acupoints in the Conception Vessel. This method is consisted of Danzhong (CV 17), Zhongwan (CV 12) and Qihai (CV 6) in the Conception Vessel, which could successively nourish clear qi, stomach qi and original qi. In clinic, according to the severity of symptoms of three qi, the acupoints are selected flexibly, which could respectively treat deficiency of heart-lung qi, deficiency of stomach-spleen qi and deficiency of original qi.

Comparative proteomic analysis of anti-cancer mechanism by periplocin treatment in lung cancer cells.

Background: Periplocin is used for treatment of rheumatoid arthritis, reinforcement of bones and tendons, palpitations or shortness of breath and lower extremity edema in traditional medicine. Our previous findings suggested that periplocin could inhibit the growth of lung cancer both in vitro and in vivo. But the biological processes and molecular pathways by which periplocin induces these beneficial effects remain largely undefined.

[Expression of carbonic anhydrase IX in NSCLC and its relationship with VEGF and Ki67 expression].

Background And Objective: It has been shown that carbonic anhydrase IX (CAIX) was closely related to tumor hypoxia. Proliferating cell nuclear antigen (Ki67) is considered to be an objective indicator which could reliable and comprehensive response to cell population proliferation; vascular endothelial growth factor (VEGF) was positively correlated with tumor angiogenesis. The aim of this study is to investigate the significance of the expression of CAIX in non-small cell lung cancer (NSCLC) tissues by analyzing the correlation between CAIX and clinical characteristics of patients with lung cancer and VEGF, Ki67 expressions.