Publications by authors named "XiangDong Wang"

Inflammatory diseases are often chronic and recurrent, and current treatments do not typically remove underlying disease drivers. T cells participate in a wide range of inflammatory diseases such as psoriasis, Crohn's disease, oesophagitis and multiple sclerosis, and clonally expanded antigen-specific T cells may contribute to disease chronicity and recurrence, in part by forming persistent pathogenic memory. Chronic rhinosinusitis and asthma are inflammatory airway diseases that often present as comorbidities.

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Microarray patches (MAPs) have been employed to deliver therapeutic payloads and for detection purposes. Research has been conducted to develop novel designs in material chemistry and the architecture of microarray, which have opened up the possibility for broader applications of MAPs. However, MAPs have yet to be clinically implemented fully.

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Background: The treatment of refractory chronic rhinosinusitis with nasal polyps (CRSwNP) with omalizumab has been well studied based on clinical evaluation. Nevertheless, ideal quantitative or qualitative biomarkers for predicting a different response to biologics urgently need to be explored. We aim to identify potential biomarkers for predicting a good or poor response in patients with refractory CRSwNP.

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Objective: The study evaluated the effectiveness and safety of single-stage versus multistage endovascular treatment in subarachnoid hemorrhage patients with Mirror Aneurysms.

Materials And Methods: Our research team performed a prospective study, focusing on the radiographic and clinical data of patients diagnosed with subarachnoid hemorrhage, specifically those who presented with Mirror Aneurysms upon admission to our institutions. According to the different endovascular treatment stages, these patients were grouped into the multistage cohort and the single-stage cohort.

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As electronics advance toward higher performance and adaptability in extreme environments, traditional metal-oxide-semiconductor field-effect transistors (MOSFETs) face challenges due to physical constraints such as Boltzmann's law and short-channel effects. Nanoscale air channel transistors (NACTs) present a promising alternative, leveraging their vacuum-like channel and Fowler-Nordheim tunneling characteristics. In this study, a novel circular gate NACT (CG-NACT) is purposed, fabricated on a 4-inch silicon-based wafer using a CMOS-compatible process.

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Background: Several epidemiological studies have shown that allergic rhinitis (AR) patients are more susceptible to coronavirus disease 2019 (COVID-19).

Objective: We aim to investigate the risk factors for COVID-19 in AR patients.

Methods: A retrospective nationwide cohort study was conducted based on a questionnaire survey in China.

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The global diversity of Proterozoic eukaryote fossils is poorly quantified despite its fundamental importance to the understanding of macroevolutionary patterns and dynamics on the early Earth. Here we report a new construction of fossil eukaryote diversity from the Paleoproterozoic to early Cambrian based on a comprehensive data compilation and quantitative analyses. The resulting taxonomic richness curve verifies Cryogenian glaciations as a major divide that separates the "Boring Billion" and Ediacaran periods, with the former characterized by a prolonged stasis, and the latter by greater diversity, more-rapid turnover, and multiple radiations and extinctions.

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Background: Hepatogastric fistula (HGF) is an uncommon occurrence that can be associated with various medical conditions. The primary causes typically involve peptic ulcer disease, infections (such as pyogenic, amoebic or tuberculosis), or iatrogenic factors (like post transarterial chemoembolization or radiotherapy). Massive gastrointestinal hemorrhage following HGF is extremely rare, with iodine-125 (I) seed migration to the stomach through HGF not previously documented.

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Calcium-dependent protein kinases (CDPKs), which are activated by transient changes in the Ca concentration in plants, are important for various biological processes, such as growth, development, defense against biotic and abiotic stresses, and others. Mannitol is commonly used as an osmotic regulatory substance in culture medium or nutrient solutions to create water-deficit conditions. Here, we cloned the potato ( L.

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Retz., known for its dried fruit, namely Chebulae Fructus, is a medicinal plant with a long-standing global reputation, which was initially recognized for its therapeutic properties during the Jin Dynasty. This review consolidates current knowledge on the traditional uses, phytochemistry, pharmacological properties, toxicity, and pharmacokinetics of Chebulae Fructus, highlighting its clinical significance and the promising therapeutic potential of its compounds.

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  • The study focuses on improving the diagnosis of primary bone tumors through machine learning and a comprehensive whole slide imaging (WSI) database of histopathological samples.
  • By using deep convolutional neural networks (DC-NN) along with imaging omics analysis, the researchers assessed the clinical value and accuracy of their diagnostic models.
  • Results showed high diagnostic accuracy for distinguishing between normal and tumor images, with impressive metrics indicating potential for better detection of primary bone tumors, including benign versus malignant classifications.
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Background: Surgery and oral corticosteroids are recommended therapies for chronic rhinosinusitis with nasal polyps (CRSwNP) patients who are nonresponsive to intranasal corticosteroid treatment.

Objective: This study aimed to compare the effectiveness of these 2 treatments in terms of improving sinus-related symptoms, enhancing quality of life, and economic costs and duration costs.

Methods: This prospective study enrolled CRSwNP patients.

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Pediatric chronic sinusitis (CRS) is a common disease within the field of otolaryngology-head and neck surgery. Due to the immaturity of sinus development and immune competence in children, its etiology and pathophysiology are complex, and its clinical features and outcomes differ significantly from those in adult patients. Currently, there are issues in the diagnosis and treatment of pediatric CRS, particularly in areas such as antibiotic use and surgical interventions, owing to a lack of sufficient attention.

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An ultra-wideband wavelength self-adaptive and high-precision single-frequency laser linewidth measurement system (SFLLMS) is constructed. The SFLLMS enables parameter measurement of the laser in the wavelength range of 1-2.05 µm with a 9 Hz linewidth measurement resolution and ±45 Hz linewidth measurement accuracy.

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The present study proposes and demonstrates a narrow-linewidth thulium-holmium co-doped fiber laser based on self-injection locking. The laser with single-longitudinal-mode operation is realized using a fiber Bragg grating as a wavelength-selection component and a dual-ring compound cavity as a mode-selection filter. The linewidth was compressed by increasing the photon lifetime by utilizing delay fibers of different lengths in the feedback cavity.

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  • Long noncoding RNAs (lncRNAs) have been linked to various immune diseases, but their role in allergic rhinitis (AR) due to house dust mites is not fully understood.
  • The study aimed to analyze the expression patterns and functions of lncRNAs in the blood of AR patients, using sequencing and bioinformatics to identify differences between these patients and healthy controls.
  • Results indicated that four specific lncRNAs were significantly upregulated in AR patients, showing correlations with allergy symptoms and inflammatory cytokines, suggesting potential diagnostic and therapeutic roles for these lncRNAs in AR management.
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  • The use of bio-based materials like polylactic acid (PLA) can help conserve fossil resources and cut carbon emissions, but PLA's limited toughness has hindered its industrial use.
  • Researchers synthesized a hyperbranched polyester (MCC-EHBP) to enhance the compatibility and toughness of PLA when blended with bio-based polyamide 11 (PA11).
  • The resulting PLA/PA11/MCC-EHBP blend significantly improved mechanical properties with tensile and impact strength increases of 36.9% and 241.7%, and also raised the decomposition temperature and activation energy of PLA, indicating better heat resistance.
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  • * The researchers created two types of foams using blends of chain extender PBAT and polylactide (PLA), one with spherical PLA particles and another with PLA nanofibers, to investigate their effects on performance.
  • * The study found that the foams with PLA nanofibers (CEPBAT/PLA-F) showed significantly improved anti-shrinkage and compression strength, outperforming those with spherical particles and only experiencing slight permanent deformation after repeated compressions.
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  • The study examines how wind and operator skill affect the performance and safety of slewing cranes, particularly their swing angles.
  • It develops an anti-swing control system using a mechanical setup and fuzzy PID control to enhance operation safety and efficiency.
  • Results indicate a significant reduction in swing angles by 88% and 75% for the lifting arm, demonstrating the effectiveness of the proposed anti-swing mechanism.
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Most patients with advanced hepatocellular carcinoma (HCC) ultimately experience tumor progression after first-line systemic therapies. Systemic therapy is generally recommended as second-line treatment for advanced HCC in the major guidelines. Combining apatinib with hepatic arterial infusion chemotherapy (HAIC) likely drives synergistic activity on advanced HCC with extrahepatic metastasis.

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In utero exposure to the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) can contribute to high rates of cleft palate (CP) formation, but the mechanistic basis for these effects remains uncertain. Here, multi-omics-based metabolomic and transcriptomic analyses were employed to characterize the etiological basis for TCDD-induced CP on gestational day 14.5 (GD14.

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  • Fibroblasts, particularly those derived from nasal polyps (NPDFs), play a key role in chronic rhinosinusitis with nasal polyps (CRSwNP) by contributing to inflammation and tissue remodeling, contrary to previous beliefs that they primarily support connective tissue.
  • A comprehensive review of literature and single-cell RNA sequencing data reveals the complex behavior of NPDFs and suggests they could be targeted for new therapies in CRSwNP.
  • Despite the promise of fibroblast-targeted treatments, understanding their specific mechanisms in CRSwNP is essential for overcoming challenges in clinical development.
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  • The emergence of advanced manufacturing technologies is creating more complex environments for robotic arms, complicating object detection due to similarities between objects and backgrounds.
  • The new WoodenCube dataset features over 5000 images of 10 block types, fully annotated to help improve detection models, alongside a novel evaluation metric called Cube-mAP for better accuracy.
  • The CS-SKNet framework has been developed to effectively capture detailed texture features and has shown superior performance on the WoodenCube dataset and strong generalization in tests with the DOTAv1.0 dataset.
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  • - Single-cell biology is rapidly evolving as a discipline that aims to improve our understanding of diseases by analyzing individual cells, but there are challenges in applying these advancements to clinical practice.
  • - The proposed clinical artificial intelligent single-cell (caiSC) system integrates various components, such as AI analyzers and molecular reference boxes, to generate clinical insights from single-cell data, facilitating better diagnoses and treatment predictions.
  • - The development of caiSCs represents a significant advancement in clinical molecular medicine, urging collaboration among scientists and clinicians to harness their potential for enhancing medical decision-making and patient care.
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  • Metabolic dysfunction-associated fatty liver disease (MAFLD) is a rising cause of chronic liver disease globally, prompting the need for dietary intervention strategies.
  • A panel of 55 international experts conducted a study to reach a consensus on dietary modifications for preventing MAFLD, covering various aspects from epidemiology to management.
  • Recommended strategies include following a balanced diet, increasing whole grains and plant-based foods, and reducing red meat and processed foods, along with advocating for physical activity and possibly maintaining Mediterranean or DASH diets.
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