LncRNA CASC11 upregulation promotes HDAC4 to alleviate oxidized low-density lipoprotein-induced injury of cardiac microvascular endothelial cells.

Long noncoding RNAs (LncRNAs) are essential to regulate the pathogenesis of coronary artery disease (CAD). This study was conducted to analyze the functionality of long noncoding RNA cancer susceptibility candidate 11 (lncRNA CASC11) in oxidized low-density lipoprotein (ox-LDL)-induced injury of cardiac microvascular endothelial cells (CMECs). CMECs were treated with ox-LDL to induce the CAD cell model.

Sulfur-Bridged Co(II)-Thiacalix[4]arene Metal-Organic Framework as an Electrochemical Sensor for the Determination of Toxic Heavy Metals.

A novel sulfur-bridged metal-organic framework (MOF) · based on thiacalix[4]arene derivatives was successfully obtained using a solvothermal method. Remarkably, adjacent ligands were linked via Co(II) cations to form a three-dimensional (3D) microporous architecture. Subsequently, was modified on a glassy carbon electrode () to produce an electrochemical sensor for the detection of heavy-metal ions (HMIs), namely, Cd, Pb, Cu, and Hg, in aqueous solutions.

Transmissive coding metasurface with dual-circularly polarized multi-beam.

The Pancharatnam-Berry (PB) phase can be used to control the phase of circularly polarized electromagnetic waves. However, there are few studies on the modulation of dual-circularly polarized multi-beam using the transmissive coding metasurface. A scheme of spin-controlling multi-beam by transmissive coding metasurface is proposed for dual-circular polarization simultaneously.

Multifunctional Coding-Feeding Metasurface Based on Phase Manipulation.

Multiple functionalities on a shared aperture are crucial for metasurfaces (MSs) in many applications. In this paper, we propose a coding-feeding metasurface (CFMS) with the multiple functions of high-gain radiation, orbital angular momentum (OAM) generation, and radar cross-section (RCS) reduction based on phase manipulation. The unit cell of the CFMS is composed of a rectangular emission patch and two quasi-Minkowski patches for reflective phase manipulation, which are on a shared aperture.

Diffusion-Weighted Magnetic Resonance Imaging in the Diagnosis of Cerebral Venous Thrombosis : A Meta-Analysis.

Objective: A role of diffusion-weighted imaging (DWI) in the diagnosis of cerebral venous thrombosis (CVT) is not wellunderstood. This study evaluates the effectiveness of DWI in the diagnosis of CVT.

Methods: Literature search was conducted in electronic databases for the identification of studies which reported the outcomes of patients subjected to DWI for CVT diagnosis.

Exploring the Potential Mechanism of Costunolide-Induced MCF-7 Cells Apoptosis by Multi-Spectroscopy, Molecular Docking and Cell Experiments.

Breast cancer is one of the most common cancer with high morbidity and mortality in women. This study aimed to explore the potential mechanism of costunolide inducing MCF-7 cells apoptosis by multi-spectroscopy, molecular docking, and cell experiments. The results manifested that costunolide interacted with calf thymus DNA (ct-DNA) in a spontaneous manner, and the minor groove as the preferential binding mode.

Incidence and clinical significance of abnormalities in potassium, sodium and calcium levels in elderly patients with hip fractures during the perioperative period.

Objective: This study aims to investigate the incidence and clinical significance of sodium, potassium and calcium electrolyte disturbances in elderly patients with hip fracture before an operation.

Methods: The clinical data of 220 patients with intertrochanteric fracture and 261 patients with femoral neck fracture from September 2013 to December 2016 in our hospital (≥60 years old) was reviewed. The sodium, potassium and calcium values, and the underlying diseases of patients were recorded after the first blood test.

Role of diffusion-weighted imaging in the diagnosis of cerebral venous thrombosis.

Objective: To evaluate the hyperintense signal (HIS) performance on diffusion-weighted imaging (DWI) in diagnosing cerebral venous thrombosis (CVT).

Methods: Seventy-eight patients with CVT hospitalized from January 2004 to January 2015 were retrospectively studied alongside 78 controls without intracranial organic diseases. Diagnostic accuracy indices of HIS on DWI or T2-weighted imaging (T2WI) to diagnose CVT at different sites and states were analyzed.

N-3-oxo-hexanoyl-homoserine lactone, a bacterial quorum sensing signal, enhances salt tolerance in Arabidopsis and wheat.

Background: N-acyl-homoserine lactones (AHLs) are the quorum sensing (QS) signal molecules to coordinate the collective behavior in a population in Gram-negative bacteria. Recent evidences demonstrate their roles in plant growth and defense responses.

Results: In present study, we show that the treatment of plant roots with N-3-oxo-hexanoyl-homoserine lactone (3OC6-HSL), one molecule of AHLs family, resulted in enhanced salt tolerance in Arabidopsis and wheat.

Spectroscopy and molecular docking analysis reveal structural specificity of flavonoids in the inhibition of α-glucosidase activity.

The inhibition of α-glucosidase activity is a prospective approach to prevent postprandial hyperglycemia. As two flavonoids extracted from citrus fruits, eriocitrin and eriodictyol have similar structures and show multiple pharmacological activities. In order to investigate the effects of flavonoids structure on enzyme inhibition, spectroscopy and molecular docking analysis were used.

Plant homeodomain finger protein 23 inhibits autophagy and promotes apoptosis of chondrocytes in osteoarthritis.

Background: Plant homeodomain finger protein 23 (PHF23) is a novel autophagy inhibitor gene that has been few studied with respect to orthopedics. This study was to investigate the expression of PHF23 in articular cartilage and synovial tissue, and analyze the relationship between PHF23 and chondrocyte autophagy in osteoarthritis (OA).

Methods: Immunohistochemical staining and western blot were applied to show the expression of PHF23 in cartilage of different outbridge grades and synovial tissue of patient with OA and healthy control.

The protective effects of a novel polysaccharide from Lentinus edodes mycelia on islet β (INS-1) cells damaged by glucose and its transportation mechanism with human serum albumin.

High glucose can lead to toxicity on islet β cells. The protective effects of a novel Lentinus edodes mycelia polysaccharide (LMP) on INS-1 cells damaged by glucose were investigated. Cell viability, lactate dehydrogenase (LDH) release, cell apoptosis, intracellular reactive oxygen species (ROS), superoxide dismutase (SOD) activity, and malondialdehyde (MDA) content were detected.

An anterior neurovascular interval approach to coronal shear fractures of the distal humerus: a prospective clinical study with short- to mid-term follow-up.

Object: To explore the treatment effect of the anterior medial neurovascular interval approach to coronal shear fractures of the distal humerus.

Methods: This prospective study included two female patients who were 30-64 years old, with a mean age of 47 years. Fractures were caused by falling from a bicycle.

Coding Anisotropic Metasurface with Integrated Broadband Tunable Radiation and Low-Scattering Performance.

In this paper, we propose a coding electromagnetic metasurface (EMMS) with integrated broadband tunable radiation and low-scattering performance. Anisotropic elements demonstrating opposite phases under x- and y-polarized incidence are investigated and coded as "0" and "1" basic elements. These elements are then arranged in an optimized layout using a simulated annealing algorithm to perform the EMMS.

Ultra-wideband and Polarization-Insensitive Perfect Absorber Using Multilayer Metamaterials, Lumped Resistors, and Strong Coupling Effects.

We theoretically and experimentally proposed a new structure of ultra-wideband and thin perfect metamaterial absorber loaded with lumped resistances. The thin absorber was composed of four dielectric layers, the metallic double split ring resonators (MDSRR) microstructures and a set of lumped resistors. The mechanism of the ultra-wideband absorption was analyzed and parametric study was also carried out to achieve ultra-wideband operation.

Angular- and Polarization-insensitive Ultrathin Double-layered Metamaterial Absorber for Ultra-wideband Application.

We proposed an ultra-thin polarization-insensitive metamaterial absorber (MMA) for ultra-wideband and wide incident angle operation. The MMA is composed of double-layer symmetric split rings (SSRs) connected with two orthogonally-arranged bars and the ground metallic plane separated by two identical substrates. Multiple metallic layers and scalabilities are employed to provide broadband absorptivity based on the cooperated mechanisms of the Ohmic loss and the Fabry-Perot interference.

Spectroscopic and molecular modeling studies on the interactions of fluoranthene with bovine hemoglobin.

This study aims to investigate the interaction between fluoranthene (FLA) and Bovine hemoglobin (BHb) by ultraviolet-visible (UV-vis) absorption, fluorescence, synchronous fluorescence, circular dichroism (CD) spectroscopy and molecular docking method. The results showed that the fluorescence intensity of BHb was declined with the increase of FLA concentration. The binding procedure was spontaneous mainly driven by hydrophobic force.

Ultra-broadband Reflective Metamaterial with RCS Reduction based on Polarization Convertor, Information Entropy Theory and Genetic Optimization Algorithm.

We proposed an ultra-broadband reflective metamaterial with controlling the scattering electromagnetic fields based on a polarization convertor. The unit cell of the polarization convertor was composed of a three layers substrate with double metallic split-rings structure and a metal ground plane. The proposed polarization convertor and that with rotation angle of 90 deg had been employed as the "0" and "1" elements to design the digital reflective metamaterial.

Application of parallel stent placement in the treatment of unruptured vertebrobasilar fusiform aneurysms.

OBJECTIVE Large vertebrobasilar fusiform aneurysms (VFAs) represent a small subset of intracranial aneurysms and are often among the most difficult to treat. Current surgical and endovascular techniques fail to achieve a complete or acceptable result because of complications, including late-onset basilar artery thrombosis and perforator infarction. The parallel-stent placement technique was established in the authors' department, and this study reports the application of this technique in the treatment of unruptured VFAs.

[Effects of umbilical cord mononuclear cells transplantation combined with hyperbaric oxygen therapy on hypoxic-ischemic brain damage in neonatal rats].

Objective: To study the effects of umbilical cord monoculcear cells (UCBMC) transplantation combined with hyperbaric oxygen (HBO) therapy on the long-term behaviors and histology in neonatal rats after hypoxic-ischemic brain damage (HIBD).

Methods: Seven-day-old Sprague-Dawley rats were randomly assigned to four groups: normal control (CON), HIBD, UCBMC and UCBMC+HBO. HIBD was induced according to the Rice-Vannucci method.

Antitumor activity of polysaccharide extracted from Pleurotus ostreatus mycelia against gastric cancer in vitro and in vivo.

The present study aimed to determine the antitumor effects of polysaccharides extracted from Pleurotus ostreatus mycelium on gastric cancer in vitro and in vivo. Polysaccharides were extracted from Pleurotus ostreatus mycelium and an antitumor component, known as Pleurotus ostreatus mycelium polysaccharides 2 (POMP2), with a relative molecular weight of 29 kDa, was then sequentially purified using Sephadex G200 size-exclusion chromatography and diethylaminoethyl-52 cellulose ion-exchange chromatography. The MTT method was used to determine the proliferation of BGC-823 cells treated with POMP2; cell migration assay, colony formation assay and in vivo antitumor tests were used to assess the effect of POMP2 on migration, cell survival and the in vivo tumor formation of BGH-823 cells.

The interleukin 3 gene (IL3) contributes to human brain volume variation by regulating proliferation and survival of neural progenitors.

One of the most significant evolutionary changes underlying the highly developed cognitive abilities of humans is the greatly enlarged brain volume. In addition to being far greater than in most other species, the volume of the human brain exhibits extensive variation and distinct sexual dimorphism in the general population. However, little is known about the genetic mechanisms underlying normal variation as well as the observed sex difference in human brain volume.

[Risk factors in carotid angioplasty and stenting for extracranial carotid stenosis of elderly patients].

Objectives: To evaluate the risk factors and safety of carotid angioplasty and stenting(CAS) for extracranial carotid stenosis in elderly patients and summarize CAS on the indication of elderly patients and the prevention of complications.

Methods: The population characteristics, clinical features and vascular data of 60 elderly patients (≥ 75 years) treated between June 2001 and December 2010 were retrospectively analyzed. There were 57 male and 3 female.