Publications by authors named "Xiang-yi Ma"
Objective: This study aimed to explore the value of M701, targeting epithelial cell adhesion molecule (EpCAM) and CD3, in the immunotherapy of ovarian cancer ascites by the in vitro assay.
Methods: The expression of EpCAM in ovarian cancer tissues was analyzed by databases. The EpCAM expression and immune cell infiltration in different foci of ovarian cancer were detected by 8-channel flow cytometry.
Objective: Due to their lower risk for induction of resistance, antimicrobial peptides with selective anticancer effect could be developed into a new generation of anticancer drugs. We conjugated an antimicrobial peptide with tumor-targeting peptides (TMTP1) to explore whether it has inhibiting effect on the progression and metastasis of transplanted prostate cancer and gastric cancer in nude mice.
Methods: Subcutaneously transplanted human prostate cancer and orthotopically transplanted human gastric cancer in nude mice were prepared.
Objective: To investigate the changes of external rotation stability of the knee after the breaking and reconstruction of the posterolateral structure (PLS) of knee joint.
Methods: The femurs of 16 fresh cadaveric lower limbs were fixed to the base of rotating holders with the knee joints in full extension, or at an angle of 30 degrees , 60 degrees , or 90 degrees ; while the tibia was attached to a free rotary holder. The external rotation of the tibia was measured with a 5 kg x m x s(-2) tibial torque.
Background & Objective: Previous researches confirmed that the mammalian target of rapamycin (mTOR) plays an important role in the tumorigenesis and development of malignant tumors. This study was to investigate the effect of rapamycin, a selective inhibitor of mTOR, combined paclitaxel on the apoptosis of ovarian cancer cell lines A2780 and SKOV3, and explore the molecular mechanism.
Methods: A2780 and SKOV3 cells were treated with rapamycin and (or) paclitaxel.
[Effects of selected phages with specific peptide ligands on the biological behaviors of ovarian cancer cells].
Zhonghua Fu Chan Ke Za Zhi
October 2005
Article Synopsis
- The study assessed how specific phages with peptide ligands impact ovarian cancer cells, using two cell lines (A2780 and SKOV3) categorized into different groups for comparison.
- The findings showed that the phages reduced cell viability (average 72.1% vs. 84.8% in controls) and increased apoptosis rates, indicating enhanced cell death in the study groups.
- Additionally, phages led to lower colony formation rates (4% vs. 15% in controls) and a decrease in invasive behavior, suggesting these phages may hinder ovarian cancer progression and metastasis.
Background & Objective: Recent research had shown that survivin, a new member of the inhibitors of apoptosis proteins (IAP) family, which also plays an important role in mitosis and cell apoptosis, and selectively overexpressed in common human cancers. This study was designed to examine the expression of survivin and its correlation with expression of Fas and FasL in ovarian epithelial carcinoma.
Methods: Immunohistochemical assay (SP method) was used to detect the expression of survivin, Fas and FasL genes in 84 ovarian cancer tissues, 39 benign tumors of ovary, and 20 normal ovary tissues.
Article Synopsis
- The study aimed to identify specific targets on the surface of epithelial ovarian cancer cells using a peptide phage display library.
- After several rounds of incubating the library with normal ovarian cells and then cancer cell lines, positive clones that bound to the cancer cells were isolated and analyzed.
- Ultimately, 10 positive clones were selected, with one candidate sequence (YYGLAEVDAGGS) identified as a target for further research.