Publications by authors named "Xiang-yan Ai"
Article Synopsis
- * It finds that patients with moderate to severe asthma have fewer Treg cells and lower levels of interleukin-10 compared to healthy individuals, while Th2 cells and interleukin-4 are higher.
- * The results suggest that an imbalance favoring Th2 cells over Treg cells could contribute to the worsening of asthma symptoms in these patients.
[Characteristics of histone deacetylase 9 in peripheral blood of patients with bronchial asthma].
Zhonghua Jie He He Hu Xi Za Zhi
May 2012
Objective: To investigate the expression pattern of histone deacetylase 9 (HDAC9) in peripheral blood of asthmatics and its effect on immune cells (Th2, Th17, Tregs) involved in the pathogenesis of asthma.
Methods: Forty-seven asthmatics from Ruijin Hospital were recruited and assigned to intermittent, mild and moderate-severe groups. Lung function test and Asthma Control Questionnaire were performed to evaluate asthma control and severity.
Background: Recent recognition is that Th2 response is insufficient to fully explain the aetiology of asthma. Other CD4(+) T cells subsets might play a role in asthma. We investigated the relative abundance and activities of Th1, Th2, Th17 and CD4(+)CD25(+) Treg cells in patients with allergic asthma.
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