Publications by authors named "Xiang-xiang Zhan"
A 71-year-old woman with recurrent papillary thyroid carcinoma (PTC) was referred to our hospital. A computed tomography scan revealed extensive recurrence in the neck, invading sternocleidomastoid muscle, internal jugular vein, sternal end of the clavicle, strap muscle and skin; and lateral compartment and subclavian lymph nodes were also involved. Multiple pulmonary micrometastases also noticed.
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- The study investigates the role of Thomsen-Friedenreich antibody (TF-Ab) and its impact on thyroid cancer (TC), specifically looking at how it may inhibit tumor growth and metastasis.
- Researchers compared TF-Ab levels in patients with primary papillary TC and found that these levels were lower than in normal individuals, with no correlation to lymph node metastasis.
- The introduction of a specific monoclonal antibody (mAb A78-G/A7) significantly impaired TC cells' ability to adhere, invade, and migrate, indicating its potential as a therapeutic agent against thyroid cancer.
The incidence of thyroid cancer has appeared as an increasing trend globally, especially in Asian countries. In this study, the expression of mucin-1 (MUC1) and Thomsen-Friedenreich antigen, Galβ1-3GalNAcα1-R (CD176) was investigated by immunohistochemistry in papillary thyroid carcinomas (PTCs), which accounts for approximately 80 % of all thyroid cancer. We found that 78 % of PTC overexpressed MUC1.
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