[Forensic analysis of 24 dismembered homicide cases in Shanghai].

Objective: To explore the characteristics of the dismembered homicide cases in Shanghai and to provide the valuable guidance for forensic pathological practices.

Methods: Twenty-four cases of dismembered homicides were selected from 2005 to 2012 in Institute of Forensic Science, Shanghai Public Security Bureau. The general information of the victims and suspects, cause of death, criminal motive, postmortem body parts, tools and information of discarding body parts were retrospectively analyzed.

[Study on electrical current mark with environmental scanning electron microscopy and energy dispersive X-ray microanalyser].

Objective: To provide objective proof on diagnosis of electrical current mark in electrocution, the environmental scanning electron microscopy and energy dispersive X-ray microanalyser (ESEM-EDX) were adopted to study the microscopic morphological characteristics and elemental composition of electrical current mark.

Methods: Morphological characteristics of electrical current marks, the elemental composition and morphology of metal particles were studied with ESEM-EDX.

Results: The electroporation and metal melted beads could be found in the electrical current marks and skin around them.

[Molecular mechanism of cyclooxygenase-2 inhibitor in inhibition of proliferation of colon cancer cells by modulating Stat5 signal transduction pathway].

Objective: To investigate the role of NS398, a selective cyclooxygenase (COX)-2 inhibitor, in proliferation and apoptosis of colorectal cancer, and to reveal the mechanism of inhibiting colon cancer by NS-398 Independent of COX-2.

Methods: Human colon cancer cells of the line SW480 were cultured and then divided into 2 groups: experimental group and control group. NS398 of the concentrations of 12.

[A study on the risk factors of cardiovascular between hypertensive patients and normal subjects in the same family].

Objective: Through studying the difference between the hypertensive patients and those with normal blood pressure who all from the same hypertensive pedigree, we tried to find the factors which would decrease the risk of hypertension.

Methods: Hypertensive patients, when coming to the cardiovascular clinic of Xuan Wu Hospital from 2003 to 2004, were defined as the members of the hypertensive pedigrees through inquiry. 84 families including 368 persons, with 192 syblings were involved.

Constitutive activation of Stat3 signaling pathway in human colorectal carcinoma.

Aim: Signal transducers and activators of transcription (STATs) are a family of transcription factors activated in response to cytokines and growth factors. Constitutive activation of Stat3 has been observed in a growing number of tumor-derived cell lines, as well as tumor specimens from human cancers. The purpose of this study was to investigate the expression of p-Stat3, activated form of Stat3, and its downstream mediators including cyclin D1 and Bcl-x(L) in colorectal carcinoma (CRC), and to explore the possible mechanism of Stat3 signaling pathway in the tumorigenesis of colorectal carcinoma.

[Relationship of Stat3 and its target gene products with malignancy in human colorectal carcinoma].

Background & Objective: Signal transducers and activators of transcription 3 (Stat3) pathway can be activated by cytokines and growth factors, and activation of Stat3 is involved in modulating cell proliferation, differentiation, and apoptosis. Stat3 has been classified as an oncogene because Stat3 can mediate malignant transformation of cultured cells. This study was conducted to investigate the expression of Stat3 and its target gene products including Cyclin D1 and Bcl-x(L) in human colorectal carcinoma (CRC) tissues and cells, and to explore the mechanisms in tumorigenesis of CRC.