Publications by authors named "Xiang-tai Kong"
Article Synopsis
- Breast cancer poses a significant health risk to women, highlighting the need for more effective treatment options; researchers are exploring the inhibition of glucose metabolism as a potential strategy.
- The newly identified GAPDH inhibitor, DC-5163, was tested for its ability to hinder breast cancer cell growth both in lab settings and in mouse models, focusing on its effects on cellular energy processes.
- Results showed that DC-5163 effectively reduced the energy supply of cancer cells, led to cell cycle arrest, increased apoptosis, and significantly suppressed tumor growth in animal models without causing major side effects.
The KRAS mutant has emerged as an important therapeutic target in recent years. Covalent inhibitors have shown promising antitumor activity against KRAS-mutant cancers in the clinic. In this study, a structure-based and focused chemical library analysis was performed, which led to the identification of 143D as a novel, highly potent and selective KRAS inhibitor.
View Article and Find Full Text PDF[Study on prevalence and correlation factors of bronchial asthma in Zaozhuang area, Shandong province].
Zhonghua Liu Xing Bing Xue Za Zhi
April 2005
Objective: To study the prevalence of asthma and its correlated factors in Zaozhuang area in 2003, to provide a basic consideration for prevention/treatment and control policy.
Methods: 6 points were selected by stratified-clusterd-random sampling with a total of 16,725 persons expected, but only 10,610 subjects investigated.
Results: In this survey, 128 asthma cases were identified with a overall prevalence of 1.