U-shaped relationship between environmental regulation and the digital transformation of the Chinese coal industry: Mechanism and moderating effects.

The coal industry faces heavy constraints from environmental regulation because of its high energy consumption and pollution. Although this industry is striving to promote digital transformation, the impact of environmental regulation on this process remains unclear. Thus, based on Chinese coal A-share listed companies from 2011 to 2022, our study examines the nonlinear relationship between environmental regulation and digital transformation, and explores the mechanism of corporate innovation, and the moderating effects of media and investor attention, respectively.

Giant mucinous liposarcoma of the abdominal cavity: A case report.

Rationale: Mucinous liposarcoma myxoid liposarcoma is a malignant mucoid soft tissue tumor derived from undifferentiated stromal cells in perivascular, subbody cavity and intermuscular space, and composed of cells at different stages of differentiation from preadipocytes to mature cells. In rare cases, it may change from lipoma malignancy. The main manifestations is painless mass, relatively slow growth, the course can last decades, the prevalence of liposarcoma in the population is 14% to 18%, mainly in adults, male prevalence is higher than women, but not significant.

Machine learning for identifying tumor stemness genes and developing prognostic model in gastric cancer.

Gastric cancer presents a formidable challenge, marked by its debilitating nature and often dire prognosis. Emerging evidence underscores the pivotal role of tumor stem cells in exacerbating treatment resistance and fueling disease recurrence in gastric cancer. Thus, the identification of genes contributing to tumor stemness assumes paramount importance.

Case Report: Semi-Ex Vivo Hepatectomy Combined with Autologous Liver Transplantation for Alveolar Echinococcosis in Children.

Hepatic alveolar echinococcosis (AE) is a zoonotic disease caused by the metacestode of Echinococcus multilocularis. Although surgical resection is the optimal treatment for hepatic AE, some patients with hepatic AE located in special introhepatic sites cannot be radically cured by conventional surgery. Here, we report that a 10-year-old female patient was admitted to the hospital with occupying liver lesions for 6 months.

Superstrong, Lightweight, and Exceptional Environmentally Stable SiO@GO/Bamboo Composites.

Development of lightweight structural materials from fast-growing bamboos is of great significance to building a sustainable society. However, previously developed structural bamboos by delignification combined with densification would easily fail under large external loading after exposure to water due to structure collapse, severely limiting their practical applications. Here, we demonstrate an ultrastrong and exceptional environmentally stable bamboo composite consisting of a graphene oxide (GO)/bamboo core and hierarchical SiO protection layer.

High-Performance Bamboo Steel Derived from Natural Bamboo.

It is highly desirable to develop green and renewable structural materials from biomaterials to replace synthetic materials involved from civil engineering to aerospace industries. Herein, we put forward a facile but effective top-down strategy to convert natural bamboo into bamboo steel. The fabrication process of bamboo steel involves the removal of lignin and hemicellulose, freeze-drying followed by epoxy infiltration, and densification combined with in situ solidification.

High-throughput lipidomics analysis to discover lipid biomarkers and profiles as potential targets for evaluating efficacy of Kai-Xin-San against APP/PS1 transgenic mice based on UPLC-Q/TOF-MS.

Lipid metabolism has a significant function in the central nervous system and Alzheimer's disease (AD) is an age-related senile disease characterized by central nerve degeneration. The pathological development of AD is closely related to lipid metabolism disorders. To reveal the influence of Kai-Xin-San (KXS) on lipid metabolism in APP/PSI transgenic mice and potential therapeutic targets for treating AD, brain tissue samples were collected and analyzed by high-throughput lipidomics based on UPLC-Q/TOF-MS.

Ultra-performance liquid chromatography/mass spectrometry technology and high-throughput metabolomics for deciphering the preventive mechanism of mirabilite on colorectal cancer the modulation of complex metabolic networks.

Colorectal cancer (CRC) is a highly virulent and malignant disease and always accompanied by metabolic disorders. Currently, there are no effective therapeutic drugs for the treatment of CRC. High-throughput metabolomics approaches have been used to unveil the metabolic pathways related to several diseases.

[Changes of inflammatory factors after hepatic cystic echinococcosis surgery and intervention of ulinastatin in Qinghai area].

Objective: To observe the changes of inflammatory factors after the hepatic cystic echinococcosis surgery and explore the intervention effect of ulinastatin on postoperative inflammatory factors.

Methods: Sixty patients with hepatic cystic echinococcosis were selected and randomly divided into a control group and ulinastatin intervention group according to whether or not use ulinastatin. The peripheral venous blood was extracted in all the patients and the levels of IL-6, IL-8, IL-9, and IL-10 were detected by the ELISA method on the day before operation, 1 day, 3 days, 5 days and 7 days after operation, respectively.

Gut microbiota as important modulator of metabolism in health and disease.

The human gastrointestinal tract colonizes a large number of microbial microflora, forms a host-microbiota co-metabolism structure with the host to participate in various metabolic processes in the human body, and plays a major role in the host immune response. In addition, the dysbiosis of intestinal microbial homeostasis is closely related to many diseases. Thus, an in-depth understanding of the relationship between them is of importance for disease pathogenesis, prevention and treatment.

High-throughput lipidomics reveal mirabilite regulating lipid metabolism as anticancer therapeutics.

Altered lipid metabolism is an emerging hallmark of cancers. Mirabilite has a therapeutic effect on colorectal cancer (CRC); however, its metabolic mechanism remains unclear. This study aims to explore the potential therapeutic targets of mirabilite protection against colorectal cancer in APC mice model.

Network pharmacology combined with functional metabolomics discover bile acid metabolism as a promising target for mirabilite against colorectal cancer.

In this study, a combination of network pharmacology and metabolomics was used to explore the mechanism by which mirabilite regulates bile acid metabolism in the treatment of colorectal cancer. The PharmMapper web server was applied to make preliminary predictions for the treatment targets of mirabilite and to predict the interaction between mirabilite and disease targets using Discovery Studio 2.5.

[Effect of Biochar on Ammonia Volatilization from Soils of Different Surface Conditions].

In order to explore the effect of biochar on the volatilization of ammonia in different surface soils, through the field test method, the responsiveness changes of ammonia volatilization, ammonium nitrogen, and urease were studied under the influence of biochar and crop cultivation. The study set six treatments:CK+, BC0.5+, and BC4.

High-throughput lipidomics characterize key lipid molecules as potential therapeutic targets of Kaixinsan protects against Alzheimer's disease in APP/PS1 transgenic mice.

Alzheimer's disease (AD) is still a major problem nowadays. Under the circumstance of many chemical drugs have poor effects on AD, traditional Chinese medicine has become a hot spot for us due to its multi-target and multi-path advantages. To explore the potential therapeutic targets of Kaixinsan (KXS) protects against AD in APP/PS1 transgenic mice model.

Identifying quality-markers from Shengmai San protects against transgenic mouse model of Alzheimer's disease using chinmedomics approach.

Background: Shengmai San (SMS), a Chinese classic herbal formula, has been widely used for the treatment of Qi-Yin deficiency syndrome in Asia. Modern pharmacological studies have shown that SMS improves the cognitive function. However, the quality markers (Q-markers) for SMS still need further research.

[Characteristics of Biochar-mediated NO Emissions from Soils of Different Surface Conditions].

It was aimed to investigate the response to biochar addition on NO gas production and emission in different surface conditions. To study the dynamic changes of soil NO release, soil nitrate(NO-N) and ammonium(NH-N), a field trials experiment was conducted from 2014 to 2015 in wheat and corn season, which contained three treatments[the blank control group (CK), biochar applied at 5 t·(hm·a)(BC5) and 45 t·(hm·a)(BC45), respectively] under crop cultivation(+) and non-cultivation(-) condition. The results indicated that:1 During the season of wheat growth, the soil NO emissions of CK+, BC5+, BC45+ were 21.

[Effects of Biochar on Surface Albedo and Soil Respiration in Suburban Agricultural Soil].

Biochar application to soils is currently considered as a means of mitigating climate change by sequestering C, which withdraws CO from the atmosphere and consequently influences the trend of global climate change. However, only a few studies have been done on surface albedo variations on farmland, it might be true that the application of biochar to soil could induce a radiative forcing by changing the surface albedo. Based on this background, this study aiming at the characterization of seasonal changes in albedo on the farmland both with plants and without plants, and its effect on soil temperature, soil moisture, soil respiration and soil organic carbon fractions.

Serum cystatin C level is associated with carotid intima-media thickening and plaque.

Background And Aim: Chronic kidney disease has recently been shown to be a major risk factor for cardiovascular disease and carotid intima-media thickness has been widely used as a biomarker for early detection of cardiovascular disease. The aim of this study was to confirm whether carotid thickening and carotid plaque are associated with preclinical chronic kidney disease in individuals without clinical cardiovascular disease and chronic kidney disease.

Material And Methods: We conducted a cross-sectional study on participants from Maanshan City, China.

Evaluation of o-xylene and other volatile organic compounds removal using a xylene-acclimated biotrickling filter.

In this study, performance evaluation for the gas-phase o-xylene removal using a xylene-acclimated biotrickling filter (BTF) was conducted. Substrate interactions during aerobic biodegradation of three poorly soluble compounds, both individually and in paired mixtures (namely, o-xylene and ethyl acetate, o-xylene and dichloromethane, which are common solvents used by pharmaceutical industry), were also investigated. Experimental results indicate that a maximum elimination capacity of 99.

[Combined three-dimensional conformal radiotherapy plus transcatheter arterial chemoembolization and surgical intervention for portal vein tumor thrombus in patients with hepatocellular carcinoma].

Objective: To explore the clinical therapeutic efficacies of combined three-dimensional conformal radiotherapy (3DCRT) plus transcatheter arterial chemoembolization (TACE) for portal vein tumor thrombus (PVTT) in hepatocellular carcinoma (HCC).

Methods: A total of 145 HCC patients with tumor thrombus in portal vein were divided randomly into 2 groups. Group A (n = 64) was treated with surgical intervention alone while group B (n = 81) underwent 3DCRT plus TACE.

[Effect of chronoexercise on circadian expression of clock genes].

Objective: To investigate the molecular biological mechanism of chronoexercise regulating circadian.

Methods: Expressions of mPer1 and mPer2 in the diencephalon of golden hamster were determined 2 hours after acute exhaustive exercise (circadian time 6) by quantitative RT-PCR.

Results: Chronoexercise at CT6 significantly decreased expressions of mPer1 and mPer2 in the diencephalon of golden hamster.