Stability and bioavailability of vitamin D3 encapsulated in composite gels of whey protein isolate and lotus root amylopectin.

A gel delivery system was developed in the present work using whey protein isolate and lotus root amylopectin via regulating pH. The texture, thermodynamics, rheology and microstructure of gels were evaluated. Results showed that pH at 7.

[Epidemiological analysis of malaria in Shandong Province in 2017].

Objective: To understand the malaria epidemiological characteristics of Shandong Province in 2017, so as to provide the evidences for formulating targeted prevention and control strategy and measures.

Methods: The data of malaria cases of Shandong Province in 2017 were collected from the Information Management System for Infectious Diseases Report and Information Management System for Parasitic Diseases Control and Prevention. The epidemiological characteristics of malaria situation and the diagnosis and treatment of malaria cases were analyzed.

[The Effects of NF-kappaB Signalling on the TNF-α induced Ratios of MMPs to TIMPs in Chondrocytes].

Objectives: To explore the influence of the NF-κB inhibitor (bay11-7082) on tumor necrosis factor-α (TNF-α)-induced different ratios of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in chondrocytes.

Methods: Chondrocytes were isolated from the knee joint of a 1-day old mouse by trypsin digestion method. Hematoxylin-Eosin (HE) stain was used to show the morphology of isolated chondrocytes; Semi-quantitative PCR was applied to analyze the influence of bay11-7082 on gene expressions of TNF-α-induced and in chondrocytes; Zymography was used to elucidate activities of the gelatinases induced by TNF-α and/or bay11-7082.

[Allele genetypes and homology analysis of MSP-1 and CSP gene of in Shandong Province].

Objective: To analyze the genotypes and homology of MSP-1 and CSP gene of in Shandong Province, so as to provide the evidence for case traceability.

Methods: A total of 12 blood samples were collected from -infected cases in Shandong Province in 2011. Parasite genomic DNA was extracted.

[Detection of Genetic Mutations Associated with Drug Resistance in Imported Plasmodium falciparum].

Objective: To investigate the mutation of genes associated with drug resistance (Pfcrt, Pfmdr1, Pfdhfr and K13） in imported Plasmodium falciparum in Shandong Province.

Methods: Blood was collected from 94 falciparum malaria cases who returned from Africa in 2014. Genomic DNA for P.

[Correlation between malaria epidemic incidence and some natural and social factors in high incidence areas of Shandong Province].

Objective: To explore the association between malaria epidemic situation and some natural and social factors in high-incidence areas of Shandong Province, so as to provide evidences for malaria elimination in these areas.

Methods: Twenty towns of 10 counties (cities, districts,) in the high incidence areas of malaria in Shandong Province were selected as the study sites, and the residents in the study sites were investigated by questionnaires with one household as a unit, so as to understand the related natural and social factors. In addition, the malaria epidemic data in the study sites from 2006 to 2010 were collected, and the correlation between these factors and the epidemic situation of malaria was analyzed by Spearman rank correlation and multiple stepwise regression.

Characteristics of Imported Malaria and Species of Plasmodium Involved in Shandong Province, China (2012-2014).

Malaria remains a serious public health problem in Shandong Province, China; therefore, it is important to explore the characteristics of the current malaria prevalence situation in the province. In this study, data of malaria cases reported in Shandong during 2012-2014 were analyzed, and Plasmodium species were confirmed by smear microscopy and nested-PCR. A total of 374 malaria cases were reported, 80.

[Epidemiological analysis of malaria prevalence in Shandong Province in 2014].

Objective: To understand the malaria epidemic situation and characteristics in Shandong Province in 2014, so as to provide evidences for taking targeted strategies and measures for malaria elimination.

Methods: The data of malaria epidemic and malaria cases of Shandong Province in 2014 were collected from Information Management System for Infectious Diseases Report and Information Management System for Parasitic Diseases Control and Prevention. The epidemiological characteristics of malaria situation and the diagnosis and treatment of malaria cases were analyzed by Microsoft Excel 2007.

Plasma Level of D-dimer is an Independent Diagnostic Biomarker for Deep Venous Thrombosis in Patients with Ischemic Stroke.

This study was to determine the clinical diagnostic value of D-dimer for DVT in patients with ischemic stroke. During July 2013 to December 2014, a cohort study of ischemic stroke patients who presented with symptoms of DVT in upper or lower extremities was performed, with a total of 255 patients at baseline. D-dimer levels were measured from each patient using Colour Doppler Ultrasonography (CDUS), and all patients underwent venous duplex examinations.

[Survey of infection situation of intestinal parasites of rural residents in plain area of Shandong Province].

Objective: To understand the current situation of infections of intestinal parasites of rural residents in four cities namely Dongying, Weifang, Jining and Heze of Shandong Province.

Methods: Twenty-four villages were randomly selected as study areas. The Kato-Katz technique was applied to test the stool samples of adult residents and the cellophane tape anus method was applied to test the infection of Enterobius vermicularis of children aged 12 years or below.

[Survey of infections of intestinal parasites and related factors in north-west Shandong Province].

Objective: To understand the infection status of intestinal parasites and related knowledge and behavior factors of the residents in north-west Shandong Province, so as to provide the evidence for taking targeted preventive measures.

Methods: Eighteen villages were randomly selected as survey spots by the stratified multi-stage sample method. The Kato-Katz technique was used to detect intestinal parasite eggs among the residents and the cellophane tape anus test was used to detect Enterobius vermicularis eggs among 3-12 years old children.

[Analysis of malaria situation and discussion of control strategy in Shandong Province, 2013].

Objective: To understand the malaria situation of Shandong Province in 2013, so as to provide the evidence for formulating targeted prevention and control strategy and measures.

Methods: The data of malaria cases of Shandong Province in 2013 were collected from the Information Management System for Infectious Diseases Report and Information Management System for Parasitic Diseases Control and Prevention. The data of epidemiological characteristics of malaria situation and the diagnosis and treatment of malaria cases were analyzed by Microsoft Excel 2007.

[Survey of intestinal parasitic infections and related knowledge and behavior of residents in Jiaodong area of Shandong Province].

Objective: To understand the status of intestinal parasitic infections and the related knowledge and behavior in residents of Jiaodong area of Shandong Province, so as to provide the evidence for making an appropriate preventive and control strategy.

Methods: A total of 18 villages from 6 counties in Jiaodong area were selected as investigation sites according to the stratified sampling method. The feces samples of the permanent residents aged above 3 years were collected and examined by Kato-Katz technique to find the intestinal parasite eggs, and the children under 12 years old were examined by the method of cellophane anal swab to detect the Enterobius vennrmicularis eggs.

[Large trophozoites in blood smear of falciparum malaria: one case report].

This paper reports one case of atypical falciparum malaria imported from Africa, whose blood smear contains many large trophozoites, with punctiform or massive brown pigment granules, the body shape of the plasmodium is similar to that of Plasmodium vivax and Plasmodium ovale. After the gene detection by PCR, the case was diagnosed as falciparum malaria. As large trophozoites were rarely seen in the peripheral blood of non-severe falciparum malaria cases, much attention should be paid to the identification of Plasmodium falciparum and other plasmodia in microscopic examinations.

TCAB1: a potential target for diagnosis and therapy of head and neck carcinomas.

Background: WRAP53, including α, β and γ isoforms, plays an important role not only in the stability of p53 mRNA, but also in the assembly and trafficking of the telomerase holoenzyme. It has been considered an oncogene and is thought to promote the survival of cancer cells. The aim of this study was to detect the role of TCAB1 (except WRAP53α) in the occurrence and development of head and neck carcinomas.

[Analysis of results of technique competition for diagnosis of parasitic diseases in Shandong Province].

Objective: To understand the capacity of Plasmodium detection and helminth detection and the mastery degree of basic knowledge of parasitic diseases.

Methods: Three professionals from each city were selected as contestants. The content of the competition contained three parts.

[Investigation on awareness status of malaria control knowledge of primary and secondary school students in Shandong Province].

Objective: To understand the awareness status of malaria control knowledge of primary and secondary school students in malaria endemic areas of Shandong Province, so as to provide the baseline information for formulating the malaria control strategy.

Methods: A cross-sectional survey was conducted in 5 Type II malaria-endemic counties in Shandong Province. A structured questionnaire survey was administrated to students in primary and secondary schools.

[Epidemiological analysis of malaria prevalence in Shandong Province in 2012].

Objective: To understand the characteristics of malaria prevalence and epidemic in Shandong Province in 2012 so as to provide the evidence for improving the work of the elimination of malaria.

Methods: The epidemiological data of malaria cases collected from the Disease Surveillance Information Reporting System of Chinese Center for Disease Control and Prevention were analyzed with the descriptive epidemiological method for epidemiological characteristics of malaria.

Results: A total of 93 malaria cases were reported in Shandong Province in 2012 with the incidence of 0.

[Analysis of malaria endemic situation in Shanxian County from 2002 to 2011].

Objective: To analyze the endemic situation of malaria in Shanxian County, Shandong Province, China in the last 10 years, so as to understand the epidemiological characteristics of the disease and provide the evidence for the establishment of control strategy to eliminate malaria.

Methods: The data related to the endemic situation of malaria in Shanxian County from 2002 to 2011 were collected and analyzed.

Results: From 2002 to 2011, 125 cases of malaria were reported, and the annual incidences were in the range of 0.

Disruption of the blood-brain barrier after generalized tonic-clonic seizures correlates with cerebrospinal fluid MMP-9 levels.

Background: Increasing evidence suggests seizures cause blood-brain barrier (BBB) dysfunction including decreased seizure threshold and higher onset potential of future seizures. However, the mechanisms underlying BBB damage in seizures remains poorly understood. Evidence in human and animal models shows BBB disruption is associated with activation of matrix metalloproteinase-9 (MMP-9) after cerebral ischemia and inflammation.

[Control strategy and practice of soil-transmitted parasitic diseases in Shandong Province].

Objective: To explore the sustainable development control strategies on soil-transmitted parasitic diseases appropriate to current epidemic characteristics so as to effectively reduce the epidemic level and harm to people in Shandong Province.

Methods: This project was led by the Shandong Medical Department, governed and instructed by the Shandong Institute of Parasitic Diseases, concretely implemented by the centers for disease control and prevention in counties or cities. All the work was carried out according to the Control Programming of National Key Parasitic Diseases, and with the combination of routine and key control strategies according to the actual situation.

[Effects of integrated malaria control measures in Shandong Province, 2010].

A total of 117 malaria patients were reported in Shandong Province, 2010 and the annual incidence was 0.13 per hundred thousand. Totally 23 cases of malaria were reported in Shanxian County, which was the most; and 6 patients who came back from Africa were reported in Daiyue County, which was the second.

Mapping of quantitative trait loci for fiber and lignin contents from an interspecific cross Oryza sativa×Oryza rufipogon.

Rice straw is always regarded as a by-product of rice production, but it could be a significant energy source for ruminant animals. Knowledge of the genetic variation and genetic architecture of cell wall traits will facilitate rice breeders by improving relevant traits through selective breeding and genetic engineering. The common wild rice, Oryza rufipogon Griff.

Interactions between small ubiquitin-like modifier 1 and nonsyndromic orofacial clefts.

Small ubiquitin-like modifier 1 (SUMO1) and environmental factors have been shown to be associated with nonsyndromic cleft lip with or without cleft palate (NSCL/P) in several populations. This study aimed at confirming the contribution of SUMO1 gene and environmental factors to nonsyndromic orofacial clefts risk in western Han Chinese. Four single-nucleotide polymorphisms were investigated in 212 case trios in western China using conditional logistic regression models and the transmission disequilibrium test under a case-parent trio design.