CCDC181 is required for sperm flagellum biogenesis and male fertility in mice.

The structural integrity of the sperm flagellum is essential for proper sperm function. Flagellar defects can result in male infertility, yet the precise mechanisms underlying this relationship are not fully understood. CCDC181, a coiled-coil domain-containing protein, is known to localize on sperm flagella and at the basal regions of motile cilia.

Total alkaloids of - and matrine-induced reactive oxygen species impair biofilm formation of and increase bacterial susceptibility to ciprofloxacin.

Objective: To investigate the mechanism by which total alkaloids of (TASA) and matrine (MT) impair biofilm to increase the susceptibility of () to ciprofloxacin.

Methods: The minimum biofilm inhibitory concentration (mBIC) was determined using a 2-fold dilution method. Structure of biofilm of was examined by Confocal Laser Scanning Microscope (CLSM).

[Relationship between chronic prostatitis and prostatic calculus].

Objective: To explore the relationship between chronic prostatitis (CP) and prostatic calculus (PC).

Methods: We used transperineal ultrasonography (TPUS) to detect PC in 500 normal volunteers and 491 CP patients, and divided them into a CP and a CP + PC group according to the ultrasonographic results. Then we analyzed the NIH-CPSI scores, duration of symptoms and white blood cell count in the expressed prostate secretion (ESP).

The investigation of the interaction between ribavirin and bovine serum albumin by spectroscopic methods.

The interaction between ribavirin (RIB) with bovine serum albumin (BSA) has been investigated by fluorescence quenching technique in combination with UV-vis absorption and circular dichroism (CD) spectroscopies under the simulative physiological conditions. The quenching of BSA fluorescence by RIB was found to be a result of the formation of RIB-BSA complex. The binding constants and the number of binding sites were calculated at three different temperatures.