Publications by authors named "Xiang-jun Yan"

Article Synopsis
  • Polysaccharides from Schisandra chinensis (SCP) have been found to have protective effects against alcohol-associated liver disease (ALD) by influencing gut health and metabolism.
  • The study observed that SCP enhances the growth of beneficial gut bacteria, specifically Lactobacillus reuteri, which helps restore gut compounds that activate the aromatic hydrocarbon receptor (AHR) and improve intestinal barrier function.
  • Overall, the research highlights that SCP supplementation can effectively prevent ALD through its impact on gut microbiota and the AHR pathway, suggesting a potential therapeutic approach for liver health.
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Alcoholic hepatitis (AH) has a high short-term mortality rate. has the potential to ameliorate liver damage and be a source of prebiotics. We aimed to investigate whether extract (SCE) can improve AH and the role of the small intestinal and cecal microbiota and their metabolites.

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Obesity continues to be a global public health challenge. seed is rich in bioactive ingredients with pharmacological effects, such as hypoglycemic activity and anti-oxidation. This study aimed to assess the potential anti-obesity effects of seed and the changes of gut microbiota and mycobiota compositions in obese zebrafish induced by a high-fat diet.

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Over a millennia, traditional Chinese medicine (TCM) has been used to treat various diseases in China. In recent years, more and more Chinese materia medica (CMM) have been studied in scientific research projects, applied in clinical practice, and their extracts have even appeared in some health products. However, the toxicity of some CMM is often overlooked, including hepatotoxicity, nephrotoxicity, neurotoxicity, cardiotoxicity, etc.

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Article Synopsis
  • Obesity is identified as a metabolic disease that alters levels of metabolites in the host and gut microbiome, prompting this study to explore how different extracts affect these changes in mice on a high-fat diet.
  • The study utilized various scientific methods to analyze how ethanol extract (IOE) and polysaccharide (IOP) can mitigate obesity-related issues, positively affecting body weight, energy intake, and metabolic processes.
  • The findings revealed that while IOE increased cecal propionate to help reduce fat accumulation, IOP boosted cecal butyrate, enhancing energy consumption and fat degradation, highlighting the distinct roles these extracts play in managing obesity through gut microbial metabolites.
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The potential of probiotics for treating ulcerative colitis (UC) has attracted increasing attention. However, more studies are still needed to guide physicians on the proper selection and use of probiotics. Here, we propose that combination of multiple probiotics with different functions can reduce intestinal inflammation.

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The single-chain variable fragment (scFv) against lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a promising molecule for its potential use in the diagnosis and immunotherapy of atherosclerosis. Producing this scFv in several milligram amounts could be the starting point for further engineering and application of the scFv. In this study, the abundant expression of the anti-LOX-1 scFv was attempted using () and .

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A new method using reflection NIR technology was developed to determine the alcoholysis degree and volatile matter of Poly-vinyl alcohol (PVA). 120 samples were used in this research. NIR spectra of the sample were scanned by the spectrometer from 1 000 to 1 800 nm.

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By using phosphoric acid as activation agent, active carbon was prepared from Thalia dealbata residues. The BET specific surface area of the active carbon was 1174.13 m2 x g(-1), micropore area was 426.

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