Publications by authors named "Xiang-guo Shi"
Aim: To investigate the tissue distribution of bitespiramycin (BSPM) and spiramycin (SPM) in rats.
Methods: Liquid chromatographic-mass spectrometric assay was applied for the determination of three major components (isovalerylspiramycins, ISV-SPMs) of BSPM and their major active metabolites (SPMs) in rat tissues and plasma after an oral dose of bitespiramycin, as well as SPMs.
Results: High levels of drug concentrations were observed in most tissues, especially in the liver, stomach, intestine, spleen, lung, womb, and pancreas.
Aim: To identify the main metabolites of aconitine in the urine of rabbits.
Methods: After oral administration of aconitine (5 mg.kg-1), the urine of male rabbits was collected and extracted by solid phase extraction and analyzed by liquid chromatography-ion trap mass spectrometry.