MicroRNA-570 promotes lung carcinoma proliferation through targeting tumor suppressor KLF9.

Increasing studies have shown that MicroRNAs (miRNAs) play critical roles in the progression of lung carcinoma. In the present study, the expression and functions of miR-570 were investigated. We found that miR-570 was significantly up-regulated in lung cancer tissues, compared with adjacent non-cancerous tissues.

Silencing of Rac3 inhibits proliferation and induces apoptosis of human lung cancer cells.

Background: Rac3, a member of the Rac family of small guanosine triphosphatases (GTPases), regulates a variety of cell functions, including the organization of the cytoskeleton, cell migration, and invasion. Overexpression of Rac3 has been reported in several human cancers. However, the role of Rac3 in lung cancer (LC) has not been determined in detail.

[The role of Smad4 and MAPK proteins in signal transduction pathway in non-small cell lung cancer].

Objective: To investigate the expression of Smad4 in non-small cell lung cancer (NSCLC), its correlation with MAPK (mitogen activated protein kinase) and their clinical significance in NSCLC.

Methods: Western blotting and RT-PCR were employed to test 42 resected lung cancers and normal lung tissues for the expression of Smad4. Imunohistochemistry was used to detect Smad4 and subtribes of MAPK in 71 paraffin samples.

[Video-assisted thoracic surgery: clinical experience among 1264 patients].

Objective: To summarize the clinical experience in video-assisted thoracic surgery (VATS).

Methods: From December 1993 to December 2005 1264 patients, 894 males and 370 females, aged 38.9 +/- 12.