Publications by authors named "Xiang-de Li"
In Southeast Asia, the prevalence of nasopharyngeal carcinoma (NPC) is high; however, the molecular mechanism governing the progression of NPC is unclear. The results of the present study revealed upregulation of ring finger protein 219 (RNF219) expression in NPC tissues and cells. Overexpression of RNF219 enhanced NPC cell invasion, migration, and proliferation; whereas knockdown of RNF219 had the opposite effects.
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- The study investigates how dose distribution affects the equivalent uniform dose (EUD) model in predicting radiation-induced brain injury in nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy (IMRT).
- It analyzes data from 103 patients, determining that an optimal volume-effect parameter can be found based on the max area under the curve (mAUC) from receiver operating characteristic (ROC) analyses, revealing that different volumes and dose levels influence predictive accuracy.
- The findings conclude that the volume-effect parameter in EUD varies with dose distribution, and using a critical-dose-volume EUD approach can enhance predictive capabilities compared to traditional dose/volume metrics.
Article Synopsis
- A study analyzed 221 patients with stage IA1-IIA1 cervical cancer to determine if adjuvant radiotherapy is needed after laparoscopic hysterectomy.
- Patients were divided into three groups: those receiving both surgery and radiotherapy (group A), those who had open surgery (group B), and those with laparoscopic surgery alone (group C).
- Results showed that groups A and B had significantly better 3-year local recurrence-free survival rates compared to group C, suggesting that adjuvant radiotherapy improves outcomes for early-stage cervical cancer, especially in stage IB patients.
Article Synopsis
- The study examines how half-brain delineation can help predict radiation damage in the temporal lobes of patients with nasopharyngeal carcinoma (NPC) undergoing intensity-modulated radiotherapy (IMRT).
- A retrospective analysis of 220 NPC cases showed significant differences in radiation doses received by the temporal lobes compared to half-brains, with specific dosimetric parameters demonstrating varying degrees of prediction accuracy for temporal lobe injury (TLI).
- The findings suggest that using half-brain delineation simplifies the contouring process and provides reliable estimates for TLI risk, making it a practical approach for NPC patient treatment planning.