A Novel RFXANK Mutation in a Chinese Child With MHC II Deficiency: Case Report and Literature Review.

Major histocompatibility complex (MHC) II deficiency is a rare primary immunodeficiency disorder that is characterized by the deficiency of MHC class II molecules. The disease is caused by transcription factor mutations including class II transactivator (), regulatory factor X-5 (), RFX-associated protein (), and RFXAP-containing ankyrin repeat (), respectively. Mutations in the gene account for >70% of all known patients worldwide.

Sonic hedgehog (Shh) and CC chemokine ligand 2 signaling pathways in asthma.

Asthma is a chronic inflammatory disease of the airways in which many cells are involved, including mast cells, eosinophils, T lymphocytes, and so on. During the process, many chemokines and mediators are released to engage in recruiting and activating eosinophils and other inflammatory cells. Also, some signaling pathways are involved in the pathobiology of asthma.

Relationship Between Immune Parameters and Non-alcoholic Fatty Liver Disease in Obese Children.

Objective: To investigate the relationship between immune parameters and non-alcoholic fatty liver disease (NAFLD) in obese children.

Design: Cross-sectional study.

Setting: Hospital-based study in Zhejiang Province, China between July to September 2015.