Publications by authors named "Xiang-Xiong Xu"
Microbial infection as a type of environmental risk factors is considered to be associated with long-term increased risk of dementia, including Alzheimer's disease (AD). AD is characterized by two neuropathologically molecular hallmarks of hyperphosphorylated tau and amyloid-β (Aβ), the latter generated by several biochemically reactive enzymes, including γ-secretase. However, how infectious risk factors contribute to pathological development of the AD core molecules remains to be addressed.
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- - The study compares two Omicron sublineages (BA.2.75 and BA.5.2) with the Delta variant to understand their effects on infection and immune response using a mouse model engineered to study human diseases.
- - Findings revealed that while Delta caused more severe lung damage, Omicron variants led to different immune responses, with BA.5.2 showing strong immune suppression and greater neurodegeneration compared to BA.2.75.
- - The differences in replication and pathogenicity among the variants are linked to how their Spike proteins interact with host cells, suggesting Omicron variants may have unique infectious characteristics that could impact neurological health.