GLP-1 plays a protective role in hippocampal neuronal cells by activating cAMP-CREB-BDNF signaling pathway against CORT+HG-induced toxicity.

Major depressive disorder (MDD) with diabetes mellitus (DM) significantly reduces the quality of the patient's life, and currently, there is no effective treatment. This study explored the feasibility of Glucagon-like peptide-1 (GLP-1) in treating MDD combined with DM. The protective effects of GLP-1 on mouse hippocampal neuronal cell line HT22 cultured with corticosterone (CORT) and high glucose (HG) were assessed.

Location of Acute Infarcts and Agitation and Aggression in Stroke.

The role of the infarct location in the development of poststroke agitation (PSA) is largely unknown. This study examined the association between the locations of infarcts and PSA at 9 months following the index stroke in 213 patients with the Chinese version of the Neuropsychiatric Inventory. Compared with the non-PSA group, PSA patients had a higher number and volume of acute pontine infarcts.

Neuroticism and Fatigue 3 Months After Ischemic Stroke: A Cross-Sectional Study.

Objective: To examine the relation between neuroticism and fatigue in Chinese patients with stroke.

Design: Cross-sectional study.

Setting: Acute stroke unit.

Poststroke agitation and aggression and social quality of life: a case control study.

Background And Objective: Aggression and agitation are common after a stroke. The association between agitation/aggression following stroke and Health-Related Quality of Life (HRQoL) in stroke survivors is unknown. This study aimed to examine the association between agitation/aggression and HRQoL in Chinese stroke survivors.

Brainstem infarcts predict REM sleep behavior disorder in acute ischemic stroke.

Background: Rapid eye movement (REM) sleep behavior disorder (RBD) is a sleep disturbance in which patients enact their dreams while in REM sleep. The behavior is typically violent in association with violent dream content, so serious harm can be done to the patient or the bed partner. The prevalence of RBD is well-known in Parkinson's disease, Lewy body dementia, and multiple systems atrophy.

Cerebral microbleeds and fatigue in stroke.

Background And Purpose: Poststroke fatigue (PSF) is a frequent and persistent problem in stroke survivors. The neuroanatomical model of PSF remains unclear. This study examined the association between PSF and cerebral microbleeds (CMBs).

[Relations between serum homocysteinemia and carotid artery plaques].

Objective: To explore the relation between homocysteinemia (HCY) and carotid artery plaque.

Methods: Subjects were derived from a cohort of Kailuan study, which was a community-based and cross-sectional. From June 2010 to June 2011, a total of 5852 subjects were selected from 101 510 working or retired employees at the Tangshan Kailuan Company in 2006 - 2007.

[Study on the inhibit mechanism primarily of extracts from Coptis on clinical resistant the medicine of Staphylococcus aureus].

Objective: To discuss the inhibit mechanism primarily of extracts from Coptis on clinical resistant the medicine of Staphylococcus aureus.

Methods: Used SDS-PAGE electrophoresis, spectrophotometry and semiautomatic biochemistry analysis to detect the accumulated concentration of norfloxacin, membranin electrophoretogram and the enzymatic activity in extracellular fluid before and after Coptis extract disposition.

Results: The accumulated concentration of medicine norfloxacin within the experiment strains which treated with Coptis extract was clear higher than that of the blank space (P < 0.

Removal of antibiotic resistance of live vaccine strain Escherichia coli MM-3 and evaluation of the immunogenicity of the new strain.

MM-3 was a live vaccine strain candidate for protecting neonatal piglets from diarrhea. Designed in the 1980s, a high degree of protection from colibacillosis was afforded to piglets in a challenge study and field trials. However MM-3 had a drawback of carrying the antibiotic resistance gene (chloramphenicol acetyltransferase gene, cat).

Construction of a novel Shigella live-vector strain co-expressing CS3 and LTB/STm of enterotoxigenic E.coli.

Aim: To construct and evaluate a polyvalent recombinant vaccine strain Shigella flexneri 2a T32 against enterotoxigenic E.coli (ETEC).

Methods: By using a host-plasmid balanced lethal system based on asd gene, a polyvalent recombinant strain was constructed to highly express CS3 and regularly express fusion enterotoxin of LTB subunit and mutant ST (LTB/STm) in a vaccine strain Shigella flexneri 2a T32 with specific deletion of asd gene.

[Effects of intermittent normobaric hypoxia training on heart rate variability].

Objective: To observe the influences of intermittent normobaric hypoxia (INH) training on heart rate variability (HRV) under hypoxia.

Method: Eight subjects were trained with INH for 4 weeks (24 d), subjects' HRV level, recorded during exposure to hypoxia (10% O2) before and after the training, were compared and analyzed.

Result: After the INH training, average of normal to normal Intervals (R-R), standard deviation of normal to normal Intervals (SDNN), total power (TP), high frequency (HF) and low frequency (LF) increased significantly during hypoxia (P<0.