Green Tea Polyphenols Prevent Early Vascular Aging Induced by High-Fat Diet via Promoting Autophagy in Young Adult Rats.

Objective: Epidemiology studies indicate that green tea polyphenols (GTP) perform a protective effect on cardiovascular diseases, but the underlying mechanisms are complex. The present study aimed to investigate the effect of GTP on high-fat diets (HFD) induced-early vascular aging.

Methods: Six-week young adult Wistar rats were fed with standard chow or HFD in the presence and absence of GTP (200 mg/kg body weight) for 18 weeks.

Detection & analysis of inflammatory cytokines in tears of patients with lacrimal duct obstruction.

Background & Objectives: Tear proteomic changes can be a candidate etiopathogenesis of lacrimal duct obstruction diseases (LDODs). Studies on proteomics have focused primarily on nasolacrimal duct obstruction, and some specific inflammatory cytokines such as interferon (IFN)-α2a, interleukin (IL)-8 and IL-10, have not been investigated. In addition, differences in inflammatory cytokines in tears according to the LDOD subtype have not been reported.

Systematic evaluation during early-phase ischemia predicts outcomes in middle cerebral artery occlusion mice.

Identifying outcome predictors for ischemic stroke is beneficial for choosing correct intervention protocols. Thus, it is necessary to systemically evaluate histological outcome-associated changes such as hemodynamics, behavior, and body weight during the early phase of ischemia. Here, 50 mice were subjected to 45-min middle cerebral artery occlusion (MCAO) using Longa's method.