Publications by authors named "Xiang-Shao Fang"
Article Synopsis
- Mitochondrial dysfunction is a key factor in brain injury following global cerebral ischemia after cardiac arrest, and carbon monoxide treatment has demonstrated protective effects against this injury.
- A study on rats with induced cardiac arrest found that those treated with carbon monoxide had improved neurological scores and lower levels of brain injury markers compared to controls.
- The carbon monoxide treatment was effective in reducing neuron damage and enhancing mitochondrial function by promoting the expression of factors related to mitochondrial biogenesis.
Background: Partial pressure of end-tidal carbon dioxide (PETCO2) has been used to monitor the effectiveness of precordial compression (PC) and regarded as a prognostic value of outcomes in cardiopulmonary resuscitation (CPR). This study was to investigate changes of PETCO2 during CPR in rats with ventricular fibrillation (VF) versus asphyxial cardiac arrest.
Methods: Sixty-two male Sprague-Dawley (SD) rats were randomly divided into an asphyxial group (n=32) and a VF group (n=30).
Aim: To investigate the effects of mesenchymal stem cells (MSCs) transplantation on rat global cerebral ischemia and the underlying mechanisms.
Methods: Adult male SD rats underwent asphxial cardiac arrest to induce global cerebral ischemia, then received intravenous injection of 5×10(6) cultured MSCs of SD rats at 2 h after resuscitation. In another group of cardiac arrest rats, tumor necrosis factor-α-induced protein 6 (TSG-6, 6 μg) was injected into the right lateral ventricle.
Objective: To explore the effects and mechanisms of heme oxygenase-1 on rats with postresuscitation myocardial dysfunction.
Methods: Male Sprague-Dawley rats were asphyxiated for 9 minutes and resuscitated. They were randomly divided into 4 groups: sham-operated, cardiopulmonary resuscitation (CPR), hemin and hemin + ZnPP (zinc protoporphyrin IX).
[The epidemiological characteristic of 97,823 cases of pre-hospital medical care in Guangzhou city].
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue
February 2011
Objective: To investigate the epidemiological information of patients in pre-hospital medical care in Guangzhou city, and to explore the characteristics of the patients.
Methods: The data in the year of 2008 were retrieved from the computer database of Guangzhou Emergency Medical Rescue Command Center.
Results: (1)In a total of 969 410 calls received, the time of distribution was found to be mainly between 16:00 and 18:00 [11.