Publications by authors named "Xiang-Qi Huang"
Article Synopsis
- Long non-coding RNAs (lncRNAs) play a significant role in breast cancer progression and metastasis, particularly under hypoxic conditions.* -
- A specific lncRNA, TCONS_I2_00001955, was found to be upregulated in various breast cancer cell lines under low oxygen, promoting cell proliferation and invasion.* -
- The presence of TCONS_I2_00001955 is linked to worse outcomes in breast cancer, including higher rates of recurrence and metastasis, indicating its potential as a poor prognostic marker.*
Intrahepatic cholangiocarcinoma (iCCA) is the second most common cancer in liver, with a high recurrence rate after surgery. Recently, we identified a CD11b-CD169-based myeloid response score (MRS), which showed remarkable prognostic potential in hepatocellular carcinoma (HCC). Here, we aimed to verify the prognostic value of the MRS in iCCA and establish an MRS-based nomogram to predict the postoperative prognosis of iCCA patients.
View Article and Find Full Text PDFIntrahepatic cholangiocarcinoma (ICC) is a highly malignant neoplasm and lack of effective treatment, characterized by dense desmoplastic stroma rich in cancer-associated fibroblasts (CAFs), which have been indicated to facilitate tumor progression in several types of human cancer. However, the clinical relevance of CAFs in ICC has not been fully characterized. Here, we evaluated the histological phenotype of CAFs and immunohistochemical expressions of α-SMA, FSP-1, and PDGFRβ in 71 ICC cases, and found that immature CAF phenotype was significantly associated with lymph node metastasis (P=.
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