A case report of small cell ovarian neuroendocrine carcinoma combined with immunochemotherapy.

Background: Small cell ovarian neuroendocrine (NE) carcinoma is a rare NE tumor with a low incidence, poor prognosis, and no standardized treatment. To date, there have been no clear reports on the efficacy or prognosis of combined immunological and chemotherapy-based approaches in patients with this type of tumor.

Methods: We administered the immune checkpoint inhibitor tirelizumab (PD-1 mab), in combination with etoposide and cisplatin chemotherapy (EP), to a patient with small cell ovarian NE carcinoma to examine its efficacy and safety.

Investigation of reducing particulate matter (PM) and heavy metals pollutions by adding a novel additive from metallurgical dust (MD) during coal combustion.

In this study, a novel additive from metallurgical dust(MD)was applied to reduce particulate matter (PM) emissions and heavy metals pollutions during coal combustion. PM samples were collected and divided into 13 stages from 0.03 μm to 10 μm.

is associated with lymph node metastasis in esophageal squamous cell carcinoma.

, of which there are few studies regarding cell biology and neurological diseases, has been found to be significantly amplified in esophageal squamous cell carcinoma (ESCC) with lymph node metastasis compared with ESCC without lymph node metastasis. This suggests that may play a role in the lymph node metastasis of ESCC. There has, to the best of our knowledge, been no study performed to investigate the role of in ESCC.

[Investigation on role of p38α mitogen-activated protein kinases in human esophageal squamous cell carcinoma cell line Eca109].

Objective: To investigate the role of p38α mitogen-activated protein kinases (MAPK) in human esophageal squamous cell carcinoma cell line Eca109.

Methods: Specific short hairpin (shRNA) vector as well as eukaryotic expression vector harbouring full length cDNA of human p38α MAPK were transfected into Eca109 cells. Cell proliferation after transfection was detected by MTT, cell cycle and apoptosis were assayed by flow cytometry.