Publications by authors named "Xiang-Nan He"
Sialic acid (SA) is a special monosaccharide widely distributed at the termini of sugar chains on the cell surface, and its expression level is closely connected with various biological and pathological processes. Therefore, accurate quantitative detection of SA on cancer cell surface is of great significance for clinical diagnosis and therapy. Here, we developed a whole-surface accessible method of accurate SERS quantification of SA level on a single cell, in which silver nanoparticles functionalized with 4-mercaptophenylboric acid and 4-mercaptobenzenitrile was used as the background-free SERS probe.
View Article and Find Full Text PDFNeonatal removal impairs neocortical development and leads to elevated anxiety.
Proc Natl Acad Sci U S A
March 2017
Article Synopsis
- Electrical coupling between excitatory neurons in the neocortex is significant during early development but is reduced as chemical synapses form later on.
- Research indicates that neonatal electrical coupling is essential for neuronal development and proper animal behavior, as shown by the effects of deleting specific genes in mouse models.
- Conditional knockout mice exhibit reduced neuronal firing, simpler dendritic structures, decreased synaptic activity, and heightened anxiety behaviors, highlighting the importance of early electrical connections in neocortical function.
The coexistence of electrical and chemical synapses among interneurons is essential for interneuron function in the neocortex. However, it remains largely unclear whether electrical coupling between interneurons influences chemical synapse formation and microcircuit assembly during development. Here, we show that electrical and GABAergic chemical connections robustly develop between interneurons in neocortical layer 1 over a similar time course.
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