Publications by authors named "Xiang-Kun Chen"
Kaohsiung J Med Sci
February 2024
Article Synopsis
- Temozolomide (TMZ) resistance is a major hurdle in treating gliomas, and this study investigates the role of lysine demethylase 4A (KDM4A) in this context.
- Researchers tested KDM4A levels in glioma cells and examined how targeting KDM4A with siRNA affects cell viability and TMZ effectiveness.
- The study found that KDM4A enhances TMZ resistance by promoting ROCK2 expression and interacting with HUWE1, suggesting that targeting KDM4A could improve glioma treatment outcomes.
