Publications by authors named "Xiang-Hui Feng"

Background: Previous studies have suggested a potential link between the crown-to-root ratio (CRR) and root morphology in patients with mild chronic periodontitis, which may be associated with tooth mobility. However, these findings have not been thoroughly investigated. Our previous study found that 76% of patients with aggressive periodontitis, particularly those with premolar involvement, exhibited abnormal root morphology, severe alveolar bone loss, and increased tooth mobility, leading to poor clinical outcomes.

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Article Synopsis
  • Periodontitis is a long-term inflammatory disease that can cause tooth loss, and a study was conducted to assess tooth survival after non-surgical treatment over an 11-year period, focusing on risk factors like the crown-root ratio.
  • The study examined 3481 teeth from 131 patients, discovering that factors like being male, having diabetes, and certain depths of gum probing were linked to increased tooth loss.
  • Results indicated a complex, nonlinear relationship between the crown-root ratio and tooth loss risk, highlighting the importance of individual assessments for predicting dental health in patients with advanced periodontitis.
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Objective: To investigate various factors affecting the clinical outcome of nonsurgical periodontal treatment and evaluate the treatment effects of adjunctive amoxicillin and metronidazole (AMX + MET) in patients with generalised aggressive periodontitis (GAgP).

Methods: Forty-two patients with GAgP were recruited and randomly assigned to three groups: scaling and root planing (SRP) only, AMX + MET after SRP, and AMX + MET during SRP. The patients were assessed every 2 months post-therapy.

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Aim: This study aimed to evaluate clinical performance of non-surgical periodontal treatment (NSPT) and its influential factors in a large Chinese population with generalized aggressive periodontitis (GAgP).

Material And Methods: Longitudinal periodontal examination data of 1,004 GAgP patients (numbers of patients with observation periods 6 weeks~, 3 months~, 6 months~, 1 year~, 3 years~ and >5 years were 203, 310, 193, 205, 70 and 23, respectively) were extracted from a hospital-based electronic periodontal charting record system and analysed by multilevel analysis.

Results: Mean probing depth (PD) and attachment loss (AL) reductions at patient level were 1.

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Objective: To investigate the potential association between FADS1 rs174537 polymorphism and serum proteins in patients with aggressive periodontitis, which may provide benefits for diagnosis and treatment of aggressive periodontitis.

Methods: A total of 353 patients with aggressive periodontitis (group AgP) and 125 matched controls (group HP) were recruited in the study. Genotyping of FADS1 rs174537 and serum biochemical indexes were tested at the study's start.

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Objective: To analyze the serum IgG titers to Aggregatibacter actinomycetemcomitans(Aa) and associated factors in patients with aggressive periodontitis (AgP).

Methods: Venous blood samples were collected from 62 AgP patients and 45 periodontal healthy controls, unstimulated whole saliva and pooled subgingival plaque samples of AgP patients were also collected for the detection of Aa (PCR method). Serum IgG titers to Aa serotype c were measured by enzyme-linked immunosorbnent assay (ELISA).

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Objective: To evaluate the differences of clinical parameters and putative periodontal pathogens in sites of different probing depth (PD) reduction after non-surgical periodontal treatment in patients with aggressive periodontitis (AgP).

Methods: Clinical examinations including plaque index, probing depth (PD), attachment level (AL) and bleeding index (BI), and full-mouth periapical photographs were collected from 20 patients with AgP. All the patients received non-surgical periodontal treatment, including oral hygiene instruction, supra-gingival scaling, subgingival scaling and root planing (SRP) and were followed up for 6 months post-therapy.

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Objective: To evaluate the status of residual alveolar bone in aggressive periodontitis (AgP) nuclear families and to investigate the influence of teeth with root abnormity on residual alveolar bone and the heredity of root abnormity, the premolar cone-root and proportion of crown and root.

Methods: Nineteen AgP probands (9 males and 10 females) at average age of 24.5 and 38 parents at average age 51.

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Objective: To investigate the accuracy of probing depth measurements of undergraduate students in department of periodontology and analyze the cause of measurement errors.

Methods: Thirty-eight dental students from Peking Universty School and Hospital of Stomatology who began their periodontal clinical practice for the first time were recruited. According to principle of clinical teaching, after the students recorded the probing depth of 1-2 periodontitis patients using Williams periodontol probe, an experienced teacher checked the probing depth.

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Objective: To establish a predictive model for long-term tooth loss of patients with aggressive periodontitis (AgP) after periodontal treatment.

Methods: Patients diagnosed as AgP in Department of Periodontology, Peking University School and Hospital of Stomatology, who were re-evaluated 3 to 11 years after periodontal treatment were enrolled (n=85). Logistic regression was performed to select background, periodontal and radiographic factors which were related to long-term post-treatment tooth loss.

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Objective: Short chain fatty acids (SCFAs), such as succinic acid, acetic acid, propionic acid, butyric acid, etc. are metabolic product of putative periodontal pathogens, which play significant roles in periodontitis. The aim of this study was to analyze the relationship between Porphyromonas gingivalis (P.

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Objective: To evaluate the short term clinical results of scaling and root planning (SRP) only, SRP combined with amoxicillin (AMX) and metronidazole (MTZ) after supragingival scaling or after SRP in the treatment of aggressive periodontitis (AgP).

Methods: A total of 45 patients with AgP were randomly divided into SRP group, SRP with AMX + MTZ after supragingival scaling group and AMX + MTZ after SRP group. Subgingival scaling and root planning were performed one week after supragingival scaling and finished within 1 month.

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Objective: To compare the outcomes of bovine porous bone mineral (BPBM) containing bone morphogenetic proteins (BMP) and BPBM alone in periodontal intra-bony defects.

Methods: In the study, 22 intrabony defects of 9 patients with periodontitis were recruited. All the patients had at least one pair of intrabony defects of ≥3 mm.

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Aggressive periodontitis comprises a group of rare, often severe, rapidly progressive forms of periodontitis mostly characterised by an early age of clinical manifestation and a distinctive tendency for cases to aggregate in families. This case report presents a 16-year-old female patient with clinical and radiographic evidence of severe attachment loss, whose mother was also a patient with severe periodontal destruction. The girl was diagnosed with generalised aggressive periodontitis and received full-mouth scaling and root planing, bone graft surgeries and guided tissue regeneration on intrabony defects mesial of the mandibular first molars.

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Objective: To investigate the potential genetic mode of aggressive periodontitis (AgP) in Chinese Han nationality.

Methods: A total of 233 subjects from 73 nuclear families were recruited. All probands were diagnosed according to the criteria of AgP in 1999 classification of periodontal diseases.

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Objective: To compare the short-term clinical effects following non-surgical periodontal treatment with Er:YAG laser or with combination of ultrasonic subgingival scaling and root planing with hand instrument (SRP) for patients with chronic periodontitis.

Methods: In the study, 17 patients with chronic periodontitis were randomly treated in a split-mouth design with Er:YAG laser (test group) or a combination of ultrasonic subgingival scaling and root planing with hand instrument (control group). The degree of discomfort experienced during the treatment was graded by the patient using visual analogue scale (VAS) immediately after the completion of test and control treatment procedures.

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Article Synopsis
  • The study investigates the link between two genetic polymorphisms, CCR2-V64I and MCP-1-2518A/G, and generalised aggressive periodontitis (GAgP) in a Chinese population.
  • Researchers analyzed blood samples from 124 GAgP patients and 94 healthy individuals to assess these gene variations using PCR-RFLP methods.
  • Results indicate that specific genotypes of CCR2 and MCP-1 may reduce the risk of GAgP in females, while in males, a potential interaction between these genotypes and smoking increases susceptibility to the disease.
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Objective: To evaluate the alveolar bone loss status and the related factors in aggressive periodontitis (AgP) patients.

Methods: A total of 108 untreated AgP patients were included. The patients averaged 27.

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Objective: To evaluate the subgingival prevalence of human cytomegalovirus (HCMV), Epstein-Barr virus-1 (EBV-1) in chronic periodontitis (CP) patients before and after treatment and to analyze the relationship between the prevalent variance and periodontal clinical parameters.

Methods: Gingival crevicular fluids of 13 CP patients were collected at baseline, 2 weeks, 2 months and 4 months after periodontal mechanical treatment. HCMV and EBV-1 were detected using nested polymerase chain reaction (n-PCR).

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Objective: To characterize serum antibody response to Aggregatibacter actinomycetemcomitans (Aa) serotype c in chronic periodontitis (CP) patients, and to observe the correlation of IgG titer with clinical parameters.

Methods: Venous blood samples were collected from 30 CP patients and 45 periodontal healthy controls, and unstimulated whole saliva and pooled subgingival plaque samples of CP patients were also collected for detection of Aa (PCR method). Serum IgG titers to Aa were measured by Enzyme-Linked Immunosorbent Assay (ELISA).

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Objective: To evaluate the subgingival prevalent rates of 6 periodontal pathogenic bacteria in gingival crevicular fluids of CP patients before and after treatment, to analyze the relationship between the prevalent variance and periodontal clinical parameters, and to provide a microbiologic method of evaluating curative effect and estimating the prognosis.

Methods: Gingival crevicular fluids of 13 CP patients were collected at baseline, 2 weeks, 2 months and 4 months after periodontal mechanical treatment. Also, gingival crevicular fluids were collected from 11 healthy subjects.

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Objective: To investigate the relationship between vitamin D receptor (VDR) gene polymorphisms and periodontitis.

Methods: Ninety patients with aggressive periodontitis(AgP), 34 patients with chronic periodontitis and 91 healthy controls were recruited in this study. VDR gene was analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) with Taq I restriction endonuclease.

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Objective: To investigate the relationship between obesity and aggressive periodontitis (AgP).

Methods: A total of 151 AgP patients and 94 healthy controls were recruited. Body weight and height were measured, and body mass index (BMI) was calculated.

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Objective: To explore the association of the single nucleotide polymorphisms (SNPs) in N-formylpeptide receptor (FPR) gene with the susceptibility of aggressive periodontitis (AgP).

Methods: A total of 94 AgP patients and 73 healthy controls were entered into the study. Peripheral blood sample was obtained from each subject by venepuncture.

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Objective: To explore a method for classifying root abnormality and to investigate the status of root abnormality in patients with aggressive periodontitis (AgP).

Methods: A total of 108 patients (2841 teeth) with AgP, 41 patients (1135 teeth) with chronic periodontitis (CP) and 30 periodontal healthy subjects (840 teeth) were included in the study. The abnormality of roots was evaluated on a full set of periapical radiographs.

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