Effect of the cytochrome P450 2D6*10 genotype on the pharmacokinetics of tramadol in post-operative patients.

The cytochrome P450 2D6 (CYP2D6) is the most highly polymorphic isoenzyme of the cytochrome P-450-system, which affects the metabolism of one-fourth of all prescription drugs. Tramadol, a narcotic-like pain reliever used to treat moderate to severe pain, is primarily metabolized by CYP2D6. The CYP2D6*10 allele is the most common allele in the Chinese population.

Effects of the N-salicylaladehyde Aminoglucose Schiff Base Complexes no O(2)(-). and DNA.

The effects of SG schiff base complexes with Cu(II), Zn(II), Co(III) on O(2)(-). and DNA were studied. The results showed that both CuSG and ZnSG could an inhibit the synthesis of O(2)(-).