Gonadotropin-releasing hormone regulates transcription of the inhibin B co-receptor, TGFBR3L, via early growth response 1.

Follicle-stimulating hormone (FSH), a product of pituitary gonadotrope cells, regulates gonadal function and fertility. FSH production is stimulated by gonadotropin-releasing hormone (GnRH) and activin-class ligands of the TGFβ family. Inhibin A and B are TGFβ proteins that suppress FSH synthesis by competitively binding activin type II receptors in concert with the co-receptors betaglycan (TGFBR3) and TGFBR3L.

Disparities in overall survival of gastric cancer patients after radical gastrectomy: an age and rural-urban residence-based cohort study with propensity score matching analysis.

This study estimated overall survival (OS) among gastric cancer patients stratified by age and rural-urban residence after radical gastrectomy. Patients (n = 286) undergoing curative gastrectomy were categorized into four groups based on age (older ≥ 60 years or younger < 60 years) and residence (rural or urban), including rural older (G1), urban older (G2), rural younger (G3) and urban younger (G4) groups. G1 presented with significantly more males, upper stomach cancers and total gastrectomies, while less patients receiving ≥ 4 cycles of adjuvant chemotherapy.

Discovery of novel seven-membered ring derivatives of ONC212 as caseinolytic protease P protein activators using the ring expansion strategy: Rational design, synthesis, and antibacterial evaluation.

Caseinolytic protease P (ClpP) protein is essential for prokaryotic and eukaryotic protein homeostasis, and has emerged as a promising bactericidal target for controlling bacterial infection and evading the emergent of drug-resistance risk. As the unique bactericidal mechanism, ClpP loses its substrate specificity and undergoes uncontrolled protein hydrolysis in the presence of an activator, leading to causing bacterial death. To further expand the chemotype of ClpP activator, a series of ONC212 derivatives were synthesized using a ring expansion strategy.

Early Recurrence of Colorectal Liver Metastasis (Number ≤ 5 and Largest Diameter ≤ 3 cm) after Resection or Thermal Ablation: a Multi-center Study of Patterns, Safety, Survival and Risk Factors.

Objective: To compare early recurrence patterns, safety, survival and investigate the clinical risk factors of early recurrence (ER) after liver resection or thermal ablation (TA) for patients with colorectal liver metastases (CRLM) with number ≤ 5 and largest diameter ≤ 3 cm.

Materials And Methods: This retrospective study included patients with CRLM who underwent liver resection or TA between January 2016 and December 2021 at two hospitals in China. The Kaplan-Meier method and log-rank test were used to assess recurrence-free survival (RFS) and overall survival (OS).

p53 activates circASCC3 to repress R-loops and enhance resistance to chemotherapy.

The tumor suppressor p53 can trigger tumor resistance to chemotherapy by facilitating DNA damage repair and maintaining genomic integrity. Here, we report that a p53-induced circular RNA circASCC3 promotes chemotherapeutic resistance by resolving R-loops. Our results reveal that p53 directly activates the transcription of , the host gene of circASCC3.

Identifying major depressive disorder among US adults living alone using stacked ensemble machine learning algorithms.

Background: It has been increasingly recognized that adults living alone have a higher likelihood of developing Major Depressive Disorder (MDD) than those living with others. However, there is still no prediction model for MDD specifically designed for adults who live alone.

Objective: This study aims to investigate the effectiveness of utilizing personal health data in combination with a stacked ensemble machine learning (SEML) technique to detect MDD among adults living alone, seeking to gain insights into the interaction between personal health data and MDD.

Specific targeting of the 5-hydroxytryptamine 2B receptor (5-HTR) demonstrates antifibrotic effects in murine models and ex vivo models of scleroderma skin.

Objectives: Systemic sclerosis (SSc) is a connective tissue disease with fibrotic remodeling of the skin and various internal organs. SSc is associated with the highest case-specific mortality of all rheumatic autoimmune diseases with limited antifibrotic treatment options. Here, we evaluated the therapeutic effects of the highly selective 5-hydroxytryptamine 2B receptor (5-HTR) inhibitor AM1476.

Prognostic Value of Changes in Combined Child-Pugh Class and ALBI Grade in Hepatocellular Carcinoma Treated with Transcatheter Intra-Arterial Therapy Plus Targeted Therapy and PD-(L)1 Inhibitors.

Purpose: This study aims to investigate liver function changes in hepatocellular carcinoma (HCC) patients treated with transcatheter intra-arterial therapy plus molecular targeted agents and programmed cell death-1 (ligand-1) inhibitors, and evaluate the prognostic significance of the combination of Child-Pugh (CP) class and albumin-bilirubin (ALBI) grade (CP/ALBI).

Methods: This is a retrospective study. A total of 149 patients from 2019 to 2023 in China were included.

Alterations in brain iron and myelination in children with ASD: A susceptibility source separation imaging study.

Autism spectrum disorder (ASD) may have both brain iron and myelin changes, but traditional methods fail to differentiate them. This study utilized an advanced susceptibility source separation technique, APART-QSM (iterAtive magnetic suscePtibility sources sepARaTion), to investigate brain iron and myelination alterations in children with ASD and link neuroimaging findings to clinical symptom severity. Sixty-five school-aged children with ASD and Sixty age- and sex-matched typically developing children were included.

Hypoxia inducible factor-1α drives cancer resistance to cuproptosis.

Cuproptosis represents a new type of cell death that intricately associated with copper homeostasis and protein lipoylation. The cuproptosis suppression has been characterized in the hypoxic tumor microenvironment (TME). Here we reveal that hypoxia inducible factor-1α (HIF-1α) is a driver of cuproptosis resistance in solid tumor.

Clinical Outcomes With Normothermic Pulsatile Organ Perfusion in Heart Transplantation: A Report From the OCS Heart Perfusion Registry.

Background: A preservation system, the Organ Care System (OCS; TransMedics) uses normothermic pulsatile perfusion during organ transport for heart transplantation. This system has demonstrated favorable outcomes in hearts recovered from extended-criteria donors after brain death (DBD) and donors after circulatory death (DCD).

Methods: The OCS Heart Perfusion Registry collects data on US heart transplantations using the OCS, static cold storage (SCS), or thoracoabdominal normothermic regional perfusion (NRP) recovered from DBD or DCD donors.

Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases.

Atrial fibrillation (AF) is the most common heart rhythm abnormality and is a leading cause of heart failure and stroke. This large-scale meta-analysis of genome-wide association studies increased the power to detect single-nucleotide variant associations and found more than 350 AF-associated genetic loci. We identified candidate genes related to muscle contractility, cardiac muscle development and cell-cell communication at 139 loci.

Epstein-Barr Virus Sequence Variations Among the Understudied Nasopharyngeal Carcinoma Patients of Diverse Ancestries in Southeast Asia.

Epstein-Barr virus (EBV) is associated with cancers, including lymphomas and nasopharyngeal carcinoma (NPC). To date, risk variants for NPC were mainly identified from Chinese populations, which dominated the world's total number of cases. Although Southeast Asia (SEA) countries have among the world's top yet intriguingly diverse NPC age-standardized incidence rates across subpopulations, data on EBV from SEA remains scarce.

Strengthening Liquid Crystal Elastomer Muscles.

ConspectusLiquid crystal elastomer fibers (LCEFs) are reversible artificial muscles capable of stimuli-responsive functions, making them promising competitors for ideal soft actuators. These remarkable actuation properties depend strongly on their mechanical properties, such as elastic modulus and breaking stress. It is necessary to strengthen the LCEF muscles to meet the demands of advanced applications.

Biomechanical impact of cortical bone vs. traditional pedicle screw trajectories: a finite element study on lumbar spinal instrumentation.

Background: Pedicle screw fixation using the cortical bone trajectory (CBT) enhances stability by engaging cortical bone, offering a valuable alternative to the traditional pedicle screw trajectory (TT). This study used finite element analysis to compare L4-5 instrumentation with CBT and TT screws, investigating whether the increased cortical bone engagement in CBT improves stability but makes it more susceptible to fatigue failure.

Methods: A L3-sacrum model was generated using anonymized CT patient data, validated against existing studies, showing consistent ROM (range of motion) values.

A retrospective study of the Dual-channels Bolus Contrast Injection (Dc-BCI) technique during endovascular mechanical thrombectomy in the management of acute ischemic stroke due to large-vessel occlusion: a technical report.

Endovascular mechanical thrombectomy (EMT) is an effective treatment for acute ischemic stroke and identifying the precise thrombus size remains key to a successful EMT. However, no imaging modality has been able to provide this information simultaneously and efficiently in an emergency setting. The present study introduces a novel technique named dual-channel bolus contrast injection (Dc-BCI) for determining thrombus size and location during EMT.

Type 2 diabetes polygenic risk score demonstrates context-dependent effects and associations with type 2 diabetes-related risk factors and complications across diverse populations.

Polygenic risk scores (PRS) hold prognostic value for identifying individuals at higher risk of type 2 diabetes (T2D). However, further characterization is needed to understand the generalizability of T2D PRS in diverse populations across various contexts. We characterized a multi-ancestry T2D PRS among 244,637 cases and 637,891 controls across eight populations from the Population Architecture Genomics and Epidemiology (PAGE) Study and 13 additional biobanks and cohorts.

Review of Artificial Intelligence in Lung Nodule Risk Assessment.

Lung cancer is the leading cause of cancerrelated mortality worldwide. In addition to localizing and segmenting lung nodules, a non-invasive risk assessment system can also help clinicians tailor treatment decisions in a timely manner, ultimately improving patient outcomes. Artificial intelligence (AI) technologies are increasingly being used in medical imaging to assess the risk of lung nodules, especially for malignancy classification.

Association of Hypocalcemia and Mean Arterial Pressure With Patient Outcome in ICU.

Objectives: We aimed to verify the relationship between hypocalcemia in the first 24 hours of ICU admission and mortality, we also hypothesized that blood pressure and blood pressure reactivity are associated with ionized calcium (iCa) and might have mediation effects in the iCa-mortality association.

Design: Retrospective, observational study.

Setting: ICUs in a general hospital.

Circ-0001283 Aggravates Cardiac Hypertrophy by Targeting Myosin Light Chain 3 Protein.

Circular RNAs (circRNAs) are differentially expressed in cardiac hypertrophy; however, the exact function and mechanisms during hypertrophy development are still unknown. Here, we explored the role of a newly discovered circRNA in the pathogenesis of myocardial hypertrophy. It was found that circ-0001283 promoted the progression of cardiac hypertrophy by interacting with myosin light chain 3 (MYL3) to inhibit the protein ubiquitination and enhance its protein expression, not by the competitive endogenous RNA mechanism.

Enhancing the decision optimization of interaction design in sustainable healthcare with improved artificial bee colony algorithm and generative artificial intelligence.

With the development of digital health, enhancing decision-making effectiveness has become a critical task. This study proposes an improved Artificial Bee Colony (ABC) algorithm aimed at optimizing decision-making models in the field of digital health. The algorithm draws inspiration from the dual-layer evolutionary space of cultural algorithms, combining normative knowledge from the credibility space to dynamically adjust the search range, thereby improving both convergence speed and exploration capabilities.

The Glycosyltransferase XYLT1 Activates NF-κB Signaling to Promote Metastasis of Early-Stage Lung Adenocarcinoma.

Early-stage lung adenocarcinoma (LUAD) generally has a favorable prognosis. However, more than 30% of early-stage LUAD cases relapse within 5 years of initial treatment, even following complete removal of the primary tumor. Identification of the factors contributing to early-stage LUAD metastasis is needed to develop effective prevention and treatment strategies.

Avenciguat: a novel soluble guanylate cyclase activator that affects multiple cell types to inhibit IFN-1 signalling and fibrosis.

Objectives: The soluble guanylate cyclase (sGC) stimulator riociguat is approved for the treatment of pulmonary arterial hypertension and may have antifibrotic effects. However, in fibrotic tissues, oxidative stress and hypoxia can render sGC insensitive to sGC stimulators. sGC activators overcome this limitation.

Unsupervised Learning-Derived Complex Metabolic Signatures Refine Cardiometabolic Risk.

Background: Cardiometabolic diseases have become a leading cause of morbidity and mortality globally. Nuclear magnetic resonance metabolomics represents a precise tool for assessing metabolic individuality.

Objectives: This study aimed to use unsupervised learning to decode plasma metabolomic profiles, providing new insights into the etiology of cardiometabolic diseases.

Customized Controllable Pyrophosphate Nanosensor Based on Lanthanide Metal-Organic Frameworks for Accurate and Sensitive Detection of Nucleic Acids.

Pyrophosphate (PPi) and nucleic acid amplification play a critical role in medical diagnostics, making the development of precise nanosensors essential. Lanthanide metal-organic frameworks (Ln-MOFs) are increasingly recognized for their potential in advanced luminescent biosensing applications. However, research on customized controllable responses in Ln-MOF nanosensors is still lacking, which is critical for the molecular-level modular design.