A rare perspective: fine-needle aspiration cytologic features of hyaline vascular type of Castleman disease: A case report.

Rationale: Castleman disease, also known as Castleman syndrome, is a rare, nonmalignant lymphoproliferative disorder. The localized subtype of this disease is primarily the hyaline vascular type of Castleman disease (HVCD). Although this disease is a benign lesion, the histologic features are similar to those of some malignant lymphomas, so an accurate diagnosis of the disease is required.

Redistribution of Electron Density for Promoting CO Conversion Capacity.

There is a need to design substrate-supported catalysts for the heterogeneous fields, especially with large porosity, which can facilitate mass transport. Herein, aiming at enhancing the performance of CO fixation, a hollow carbon sphere-supported catalyst of Fe/HCS (Fe, Fe nanoparticles; HCS, hollow carbon sphere) is facilely designed and fabricated. Excitingly, the experimental and calculation results reveal that Fe/HCS displays an ultrahigh activity with almost complete conversions in CO cycloaddition, surpassing the performance of Fe/CS (CS, carbon sphere); this demonstrates that the HCS plays a key role, which may be attributed to the hollow structure tuning the electron density and enhancing the enrichment of the substrate and CO, consequently lowering the barrier associated with mass transfer.

Targeting CFTR restoring aggrephagy to suppress HSC activation and alleviate liver fibrosis.

Background And Aims: Multiple studies have shown that hepatic fibrosis, a progressive condition that represents the endpoint of various chronic liver diseases, is primarily marked by the extensive activation of hepatic stellate cells (HSCs). However, the exact impact of cystic fibrosis transmembrane conductance regulator (CFTR) on HSCs during the development of hepatic fibrosis remains unclear.

Methods: In our study, we measured CFTR levels in tissue samples and in HSCs activated by TGF-β stimulation.

Macrophage-Targeting and Hydrogen-Peroxide-Responsive Fluorescent Probe for Imaging of Inflammation In Vivo.

An uncontrolled immune response leads to many diseases; therefore, monitoring inflammation is crucial for the diagnosis of subsequent diseases, drug screening, and targeted therapy. Since the inflammatory response mainly occurs in macrophages, there is a need to develop more inflammatory probes with macrophage-targeting ability. Herein, we designed a macrophage-targeted and hydrogen-peroxide-activated fluorescent probe for real-time imaging of inflammation in vivo and a control probe without the macrophage-targeting part.

Driving fingerprinting enhances drowsy driving detection: Tailoring to individual driver characteristics.

Background: Drowsiness detection is a long-standing concern in preventing drowsiness-related accidents. Inter-individual differences seriously affect drowsiness detection accuracy. However, most existing studies neglected inter-individual differences in measurements' calculation parameters and drowsiness thresholds.

Novel Ternary System for Electrochemiluminescence Biosensor and Application toward Pb Assay.

This study constructed an electrochemiluminescence (ECL) biosensor for ultrasensitive detection of Pb in a ternary system by employing DNAzyme. The ternary system is composed of a potassium-neutralized perylene derivative (KPTC) as the ECL emitter, KSO as the coreactant, and neodymium metal-organic frameworks (Nd-MOFs) as the coreaction accelerators. Nd-MOFs immobilize DNAzymes and enhance the luminescence intensity of the KPTC/KSO system.

Fast-response fiber organic electrochemical transistor with vertical channel design for electrophysiological monitoring.

Fiber organic electrochemical transistors (OECTs) hold significant promise for bio-signal amplification due to their minimally invasive and seamless integration with biological tissues. However, their use in monitoring rapid physiological changes, such as electrophysiological signals, has been constrained by slow response time, arising from their extensive channel dimensions. Here, we introduce a novel fiber OECT designed with a micro-scale vertical channel (F-vOECT) that substantially reduces the response time by an order of magnitude to 12 ms and achieves a maximum transconductance of 16 mS at zero gate bias, marking a substantial improvement over previous fiber OECTs.

LAMTOR1 decreased exosomal PD-L1 to enhance immunotherapy efficacy in non-small cell lung cancer.

Great progress has been made in utilizing immune checkpoint blockade (ICB) for the treatment of non-small-cell lung cancer (NSCLC). Therapies targeting programmed cell death protein 1 (PD-1) and its ligand PD-L1, expressed on tumor cells, have demonstrated potential in improving patient survival rates. An unresolved issue involves immune suppression induced by exosomal PD-L1 within the tumor microenvironment (TME), particularly regarding CD8 T cells.

A Triple Signal Amplification Strategy for Accurate and Ultrasensitive miRNA-21 Detection.

A triple signal amplification strategy was integrated with a built-in double electrode and external energy storage device to fabricate a novel self-powered biosensor for ultrasensitive detection of miRNA-21. Specifically, DNA tetrahedra and haripin2-glucose oxidase are modified on the surface of the biocathode and bioanode by catalytic hairpin assembly (CHA) to achieve dual signal amplification. Moreover, triple signal amplification is realized by including an external capacitor.

Novel Self-Powered Biosensor Based on Au Nanoparticles @ Pd Nanorings and Catalytic Hairpin Assembly for Ultrasensitive miRNA-21 Assay.

An ultrasensitive self-powered biosensor is constructed for miRNA-21 detection based on Au nanoparticles @ Pd nanorings (Au NPs@Pd NRs) and catalytic hairpin assembly (CHA). The Au NPs@Pd NRs possess excellent electrical conductivity to improve the electron transfer rate and show good elimination of byproduct HO to assist glucose oxidase (GOD) to catalyze glucose; CHA is used as an amplification strategy to effectively enhance the sensitivity of the biosensor. To further amplify the output signal, a capacitor is integrated into the self-powered biosensor.

The impact of a growth mindset on high school students' learning subjective well-being: the serial mediation role of achievement motivation and grit.

Purpose: The learning subjective well-being of high school students has significant value for their academic achievement and future life development. A growth mindset is one of the key factors affecting the learning subjective well-being of high school students. However, research on the mechanism by which a growth mindset affects learning subjective well-being is still relatively limited.

An ultra-sensitive and rapid immunosensor for the onsite detection of circulating tumor DNA in breast cancer.

Breast cancer currently stands as the most prevalent form of cancer worldwide and the primary cause of cancer-related deaths among women. However, the current diagnostic methods for breast cancer exhibit several limitations, including invasiveness, high costs, and limited sensitivity and specificity. The detection of the PIK3CA-H1047R variant is of paramount importance due to its close association with tumor growth and treatment resistance.

Microbial stratification and DOM removal in drinking water biofilters: Implications for enhanced performance.

Biofiltration is a low-cost, low-energy technology that employs a biologically activated bed of porous medium to reduce the biodegradable fraction of the dissolved organic matter (DOM) pool in source water, resulting in the production of drinking water. Microbial communities at different bed depths within the biofilter play crucial roles in the degradation and removal of dissolved organic carbon (DOC), ultimately impacting its performance. However, the relationships between the composition of microbial communities inhabiting different biofilter depths and their utilisation of various DOC fractions remain poorly understood.

[Estrogen receptor Esr1 induces early ovarian differentiation in ].

This study aims to explore the roles of three estrogen receptors (Esr1, Esr2, and Gper1) in early differentiation of embryonic gonads of . The expression characteristics of the receptor genes were studied first. The Esr1, Esr2, and Gper1 agonists PPT, WAY 200070, and G-1 were respectively injected into the embryos at the male-producing temperature (MPT) before initiation of gonadal differentiation.

Ultrasensitive Electrochemiluminescence Biosensing Platform Based on Polymer Dots with Aggregation-Induced Emission for Dual-Biotoxin Assay.

Multitarget assay has always been a hot topic in electrochemiluminescence (ECL) methods. Herein, a "on-off-on" ECL aptasensor was developed for the ultrasensitive and sequential detection of possible biological warfare agents, deoxynivalenol (DON) and abrin (ABR). As a luminophore, polymer dots (Pdots) with aggregation-induced emission exhibit high ECL efficiency in the aptasensor, i.

Navel orange peel essential oil inhibits the growth and progression of triple negative breast cancer.

Background: Triple Negative Breast Cancer (TNBC) is a particular type of breast cancer with the highest mortality rate. Essential oils are concerned more and more as potential anti-cancer drugs.

Methods: TNBC cells were treated with different concentrations of navel orange peel essential oil (NOPEO), and then a variety of  experiments were performed to investigate the changes in the growth and progression of TNBC cells.

Direct effects of barley yellow dwarf virus on the performance, parasitoid resistance, and feeding behavior of its vector Sitobion avenae (Hemiptera: Aphididae).

Background: The complex interaction between plant viruses and their insect vectors is the basis for the epidemiology of plant viruses. The 'Vector Manipulation Hypothesis' (VMH) was proposed to demonstrate the evolution of strategies in plant viruses to enhance their transmission to new hosts through direct effects on insect vector behavior and/or physiology. However, the aphid vectors used in previous studies were mostly obtained by feeding on virus-infected plants and as a result, it was difficult to eliminate the confounding effects of infected host plants.

PdPt@SnS Nanosheets for a Novel Ultrasensitive Electrochemiluminescence Biosensor for miRNA-21 Assay.

PdPt nanosheets decorated on SnS nanosheets (i.e., PdPt@SnS NSs) were fabricated for a novel electrochemiluminescence (ECL) biosensor for ultrasensitive detection of miRNA-21 based on catalytic hairpin assembly (CHA) cycles.

High-performance fibre battery with polymer gel electrolyte.

Replacement of liquid electrolytes with polymer gel electrolytes is recognized as a general and effective way of solving safety problems and achieving high flexibility in wearable batteries. However, the poor interface between polymer gel electrolyte and electrode, caused by insufficient wetting, produces much poorer electrochemical properties, especially during the deformation of the battery. Here we report a strategy for designing channel structures in electrodes to incorporate polymer gel electrolytes and to form intimate and stable interfaces for high-performance wearable batteries.

Structural elucidation and anti-psoriasis activity of a novel polysaccharide from Saussurea Costus.

PSCP, a novel water-soluble polysaccharide, was extracted from the root of Saussurea costus and subsequently purified using DEAE-52 cellulose and Sephadax G-50 columns. The elucidation of its structure involved various techniques including HPGPC, FT-IR, HPLC-ELSD, GC-MS, NMR, AFM, and SEM. The results show that PSCP was a homogeneous heteropoly saccharide having molecular weight of 4131 Da and mainly composed of 1-α-D-Glcp-(-2-β-D-Fruf-1-)-2-β-D-Fruf.